Home Cart 0 Sign in  

[ CAS No. 134003-83-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 134003-83-1
Chemical Structure| 134003-83-1
Structure of 134003-83-1 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 134003-83-1 ]

Related Doc. of [ 134003-83-1 ]

Alternatived Products of [ 134003-83-1 ]

Product Details of [ 134003-83-1 ]

CAS No. :134003-83-1 MDL No. :MFCD28411213
Formula : C17H24N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 288.39 Pubchem ID :-
Synonyms :

Safety of [ 134003-83-1 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 134003-83-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 134003-83-1 ]
  • Downstream synthetic route of [ 134003-83-1 ]

[ 134003-83-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 134003-83-1 ]
  • [ 134003-84-2 ]
YieldReaction ConditionsOperation in experiment
93.4% With hydrogen In ethanol for 16 h; Example 15B
tert-butyl (1R,4R)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
The product from Example 15A (2 g, 6.9 mmol) in 50 mL of EtOH was treated with 10percent Pd/C (150 mg) under an H2 atmosphere (1 atm) for 16 hours.
The mixture was filtered and the solvent was evaporated under reduced pressure to yield 1.28 g (93.4 percent) of the title compound. 1H NMR (DMSO-d6, MHz) δ 1.39 (s, 9H), 1.54 (d, J=5.6 Hz, 1H), 1.58 (t, J=9.5 Hz, H), 2.70-2.81 (M, 2H), 3.50 (dd, J=1.02, 10.50, 1H), 3.17 (m, 1H), 3.50 (s, 1H), 4.17 (d, J=10.17 Hz, H); MS (DCI/NH3) m/z 199 (M+H)+, 216 (M+NH4)+.
93.4% With hydrogen In ethanol for 16 h; The product from Example 15A (2 g, 6.9 mmol) in 50 mL of EtOH was treated with 10percent Pd/C (150 mg) under an H2 atmosphere (1 atm) for 16 hours. The mixture was filtered and the solvent was evaporated under reduced pressure to yield 1.28 g (93.4percent) of the title compound. 1H NMR (DMSO-d6, MHz) δ 1.39 (s, 9H), 1.54 (d, J=5.6 Hz, 1H), 1.58 (t, J=9.5 Hz, H), 2.70-2.81 (M, 2H), 3.50 (dd, J=1.02, 10.50, 1H), 3.17 (m, 1H), 3.50 (s, 1H), 4.17 (d, J=10.17 Hz, H); MS (DCIINH3) m/z 199 (M+H)+, 216 (M+NH4)+.
93.4% With hydrogen In ethanol for 16 h; Example 25B
tert-butyl(1R,4R)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
The product from Example 25A (2 g, 6.9 mmol) in 50 mL of EtOH was treated with 10percent Pd/C (150 mg) under an H2 atmosphere (1 atm) for 16 hours.
The mixture was filtered and the solvent was evaporated under reduced pressure to yield 1.28 g (93.4percent) of the title compound. 1H NMR (DMSO-d6, MHz) δ 1.39 (s, 9H), 1.54 (d, J=5.6 Hz, 1H), 1.58 (t, J=9.5 Hz, H), 2.70-2.81 (M, 2H), 3.50 (dd, J=1.02, 10.50. 1H), 3.17 (m, 1H), 3.50 (s, 1H), 4.17 ppm (d, J=10.17 Hz, H); MS (DCl/NH3) m/z 199 (M+H)+, 216 (M+NH4)+.
Reference: [1] Patent: EP1147112, 2003, B1, . Location in patent: Page/Page column 19
[2] Patent: US2003/225268, 2003, A1, . Location in patent: Page 21
[3] Patent: US2005/101602, 2005, A1, . Location in patent: Page/Page column 37
[4] RSC Advances, 2015, vol. 5, # 14, p. 10386 - 10392
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3627 - 3644
Same Skeleton Products
Historical Records