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[ CAS No. 13434-13-4 ]

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2D
Chemical Structure| 13434-13-4
Chemical Structure| 13434-13-4
Structure of 13434-13-4 *Storage: {[proInfo.prStorage]}

Quality Control of [ 13434-13-4 ]

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Related Doc. of [ 13434-13-4 ]

SDS

Product Details of [ 13434-13-4 ]

CAS No. :13434-13-4MDL No. :MFCD00080257
Formula :C19H35N3O5Boiling Point :-
Linear Structure Formula :-InChI Key :N/A
M.W :385.50Pubchem ID :-
Synonyms :

Computed Properties of [ 13434-13-4 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 13434-13-4 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P280-P301 P312-P302 P352-P305 P351 P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 13434-13-4 ]

  • Downstream synthetic route of [ 13434-13-4 ]

[ 13434-13-4 ] Synthesis Path-Downstream   1~2

  • 1
  • aqueous sodium periodate [ No CAS ]
  • [ 13434-13-4 ]
  • (2S)-2-pentylsuccinyl-L-valyl-L-prolinol [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium chloride; In diethyl ether; water; EXAMPLE 1 Synthesis of (2S)-2-pentylsuccinyl-L-valyl-L-prolinol of the formula (III) Actinonin (1.0 g) was suspended in water (100 ml), followed by addition of 15N aqueous sodium periodate (25 ml) to resulting aqueous suspension of [13434-13-4]actinonin. The suspension was then stirred overnight at room temperature so as to conduct the dehydroxyamination reaction, whereby the hydroxyamino group was removed from the [13434-13-4]actinonin molecule. The reaction mixture obtained was saturated with sodium chloride and then extracted with ethyl ether (100 ml). The resulting ethyl ether layer (i.e., the extract solution) was thereafter extracted twice with saturated aqueous sodium hydrogen carbonate (100 ml). The aqueous phases (the extract solutions) thus obtained were combined together and adjusted to pH 2 with 1N HCl. The resultant aqueous solution was saturated with sodium chloride and then extracted with ethyl ether (150 ml). The resulting extract solution in ethyl ether was dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated to dryness, thereby affording the titled compound of the formula (III) as a colorless syrupy residue (790 mg). Mass spectrum: m/z 370 (M+).
YieldReaction ConditionsOperation in experiment
j) Treatment of a suspension of O-benzylhydroxyamine hydrochloride 18 in a suitable solvent with triethylamine followed by a solution of a pyrrolidine-1-carbonyl-2-methylalkylcarbamoyl)-alkynoic acid 2,5-dioxo-pyrrolidin-1-yl ester or a derivative thereof in a suitable solvent to afford N4-benzyloxy-N1-(1-(pyrrolidine-1-carbonyl)-2-methylalkyl-2-alkyl-succinamide or a derivative thereof.
j) Treatment of a suspension of O-benzylhydroxyamine hydrochloride 18 in a suitable solvent with triethylamine followed by a solution of a pyrrolidine-1-carbonyl-2-methylalkylcarbamoyl)-alkyoic acid 2,5-dioxo-pyrrolidin-1-yl ester or a derivative thereof in a suitable solvent to afford N4-benzyloxy-N1-(1-(pyrrolidine-1-carbonyl)-2-methylalkyl-2-alkyl-succinamide or a derivative thereof.
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