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[ CAS No. 1346229-43-3 ] {[proInfo.proName]}

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Chemical Structure| 1346229-43-3
Chemical Structure| 1346229-43-3
Structure of 1346229-43-3 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1346229-43-3 ]

CAS No. :1346229-43-3 MDL No. :
Formula : C16H27NO5 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 313.39 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1346229-43-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1346229-43-3 ]

[ 1346229-43-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 203662-51-5 ]
  • [ 1346229-43-3 ]
  • 2
  • [ 1346229-43-3 ]
  • [ 1341034-85-2 ]
YieldReaction ConditionsOperation in experiment
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 1h; 91.A; 2 Step A Racemic tert-butyl 3-(hydroxymethyl)-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate: To a solution of 9-tert-butyl 3-methyl 1-oxa-9-azaspiro[5.5]undecane-3,9-dicarboxylate (23 g, 73.4 mmol) (for synthetic route for this reagent, see: Cernak, T.; Dykstra, K.; eyorse, D.; Verras, A.;Balkoyec, J.; Nargund, R.; DeVita, R. Tetrahedron ett. 2011, 52, 6457-6459.) in THF (50 mL) was added slowly at rt lithium aluminum hydride in THF (55.0 ml, 110 mmol) over 30 min. The resultant was stirred at rt for 0.5 h. The mixture was cooled to 0°C, quenched with 5 ml of water dropwise until the mixture was like frozen solid, then added 5 mL of 5 N NaOH. The mixture was stirred at rt for 40 min, filtered off the solid and washed with EtOAc. The combined organic solution was dried over anhydrous MgSO4, filtered, and concentrated to give the title compound.
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 1h;
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