Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 1346229-43-3 | MDL No. : | |
Formula : | C16H27NO5 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 313.39 | Pubchem ID : | - |
Synonyms : |
|
Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 1h; | 91.A; 2 Step A Racemic tert-butyl 3-(hydroxymethyl)-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate: To a solution of 9-tert-butyl 3-methyl 1-oxa-9-azaspiro[5.5]undecane-3,9-dicarboxylate (23 g, 73.4 mmol) (for synthetic route for this reagent, see: Cernak, T.; Dykstra, K.; eyorse, D.; Verras, A.;Balkoyec, J.; Nargund, R.; DeVita, R. Tetrahedron ett. 2011, 52, 6457-6459.) in THF (50 mL) was added slowly at rt lithium aluminum hydride in THF (55.0 ml, 110 mmol) over 30 min. The resultant was stirred at rt for 0.5 h. The mixture was cooled to 0°C, quenched with 5 ml of water dropwise until the mixture was like frozen solid, then added 5 mL of 5 N NaOH. The mixture was stirred at rt for 40 min, filtered off the solid and washed with EtOAc. The combined organic solution was dried over anhydrous MgSO4, filtered, and concentrated to give the title compound. | |
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 1h; |