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[ CAS No. 1354639-60-3 ] {[proInfo.proName]}

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Chemical Structure| 1354639-60-3
Chemical Structure| 1354639-60-3
Structure of 1354639-60-3 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1354639-60-3 ]

CAS No. :1354639-60-3 MDL No. :MFCD31923017
Formula : C14H15NO4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 261.27 Pubchem ID :-
Synonyms :

Safety of [ 1354639-60-3 ]

Signal Word: Class:N/A
Precautionary Statements: UN#:N/A
Hazard Statements: Packing Group:N/A

Application In Synthesis of [ 1354639-60-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1354639-60-3 ]
  • Downstream synthetic route of [ 1354639-60-3 ]

[ 1354639-60-3 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1354639-60-3 ]
  • [ 103-69-5 ]
  • [ 248282-01-1 ]
YieldReaction ConditionsOperation in experiment
93% for 2 h; Reflux; Molecular sieve A mixture of 4 (5.00 g) and N-ethylaniline (4.7 g) in n-heptane (200 mL) was refluxed in a Soxhlet extraction apparatus (Figure 1) containing 4A molecular sieves (22.9 g). The reflux was stopped after 2.0 hours and the mixture was cooled to room temperature. The crystalline suspension was filtered. The precipitate was washed with n-heptane and dried in vacuum to furnish 5.53 g (82 percent) of N-ethyl-N-phenyl-5-ethyl-l,2-dihydro-4-hydroxy-l-methyl-2-oxo- quinoline-3-carboxamide (A). 1 H-NMR analysis on the isolated product revealed 2percent remaining ester. 1 H-NMR (d-DMSO), all broad peaks; 11.1 (1H), 7.41 (1H), 7.29 (2H), 7.21 (3H), 7.14 (1H), 6.96 (1H), 3.80 (2H), 3.42 (3H), 3.08 (2H), 1.07 (3H), 1.06 (3H).When the same reaction was performed by the traditional distillation from n-heptane (Entry 22) during 2 hours according to prior art US patent No. 6,875,869 the product was isolated in 85 percent yield (based on compound A) and found by 1H-NMR to be a mixture of compound A (75 molpercent) and the ester used as starting material (25 molpercent).
Reference: [1] Patent: WO2012/4338, 2012, A1, . Location in patent: Page/Page column 13; 15
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