There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
type | HazMat fee |
Excepted Quantity | Free |
Ground (Domestic only) | Free |
Inaccessible (Haz class 6.1), Domestic | USD 41.00 |
Inaccessible (Haz class 6.1), International | USD 64.00 |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 83.00 |
Accessible (Haz class 3, 4, 5 or 8), International | USD 133.00 |
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CAS No. : | 137266-85-4 | MDL No. : | MFCD16660804 |
Formula : | C14H18ClNO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | N/A |
M.W : | 267.75 | Pubchem ID : | 59526760 |
Synonyms : |
|
TPSA :Topological Polar Surface Area | - | H-Bond Acceptor Count : | - |
XLogP3 : | - | H-Bond Donor Count : | - |
SP3 : | - | Rotatable Bond Count : | - |
Signal Word: | Danger | Class | 6.1 |
Precautionary Statements: | P201-P202-P261-P264-P270-P271-P280-P302 P352-P304 P340-P308 P313-P310-P330-P361-P403 P233-P405-P501 | UN#: | 2811 |
Hazard Statements: | H301-H311-H331-H341 | Packing Group: | Ⅲ |
GHS Pictogram: |
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Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; In diethyl ether; dichloromethane; | Preparation 3 Ethyl 1-benzyl-3-(chloromethyl)azetidine-3-carboxylate hydrochloride A solution of sodium ethoxide (21% wt. in ethanol, 66.3 mL, 205.0 mmol) in ethanol (70 mL) was added to a solution of 1-benzyl-3,3-bis(chloromethyl)azetidin-2-one (50.4 g, 195.0 mmol) (Preparation 2) in ethanol (210 mL) at 0 C. The mixture was stirred at reflux for 20 hours and then partitioned between water (200 mL) and dichloromethane (300 mL). The aqueous layer was re-extracted with dichloromethane (100 mL) and the combined organic solution was dried over magnesium sulfate and concentrated under reduced pressure to afford an orange oil. A solution of the oil in dichloromethane (100 mL) was treated with a solution of hydrogen chloride in diethyl ether (1M, 250 mL) and the resulting gummy precipitate was triturated with ethyl acetate to afford the title compound as a white solid in 73.2% yield, 43.5 g. 1H NMR (400 MHz, CD3OD) delta: 1.32 (t, 3H), 4.11 (s, 2H), 4.31 (m, 4H), 4.47 (m, 4H), 7.51 (m, 5H); LRMS APCI m/z 268 [MH]+ | |
With hydrogenchloride; In diethyl ether; dichloromethane; | A solution of sodium ethoxide (21 % wt. in ethanol, 66.3 ml_, 205.0 mmol) in ethanol (70 ml_) was added to a solution of the compound described in Preparation 2 (50.4 g, 195.0 mmol) in ethanol (210 ml_) at 0C. The mixture was stirred at reflux for 20 hours and then partitioned between water (200 ml_) and dichloromethane (300 ml_). The aqueous layer was re-extracted with dichloromethane (100 ml_) and the combined organic solution was then dried over magnesium sulfate and concentrated under reduced pressure to afford an orange oil. A solution of the oil in dichloromethane (100 ml_) was treated with a solution of hydrogen chloride in diethyl ether (1 M, 250 ml_) and the resulting gummy precipitate was triturated with ethyl acetate to afford the title compound as a white solid in 73.2% yield, 43.5 g.1H NMR (400 MHz, CD3OD) delta: 1.32 (t, 3H), 4.11 (s, 2H), 4.31 (m, 4H), 4.47 (m, 4H), 7.51 (m, 5H); LRMS APCI m/z 268 [MH]+ |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
for 20h;Heating / reflux; | Preparation 3 Ethyl 1-benzyl-3-(chloromethyl)azetidine-3-carboxylate hydrochloride A solution of sodium ethoxide (21% wt. in ethanol, 66.3 mL, 205.0 mmol) in ethanol (70 mL) was added to a solution of 1-benzyl-3,3-bis(chloromethyl)azetidin-2-one (50.4 g, 195.0 mmol) (Preparation 2) in ethanol (210 mL) at 0 C. The mixture was stirred at reflux for 20 hours and then partitioned between water (200 mL) and dichloromethane (300 mL). The aqueous layer was re-extracted with dichloromethane (100 mL) and the combined organic solution was dried over magnesium sulfate and concentrated under reduced pressure to afford an orange oil. A solution of the oil in dichloromethane (100 mL) was treated with a solution of hydrogen chloride in diethyl ether (1M, 250 mL) and the resulting gummy precipitate was triturated with ethyl acetate to afford the title compound as a white solid in 73.2% yield, 43.5 g. 1H NMR (400 MHz, CD3OD) delta: 1.32 (t, 3H), 4.11 (s, 2H), 4.31 (m, 4H), 4.47 (m, 4H), 7.51 (m, 5H); LRMS APCI m/z 268 [MH]+ |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; for 20h;Heating / reflux; | A solution of sodium ethoxide (21 % wt. in ethanol, 66.3 ml_, 205.0 mmol) in ethanol (70 ml_) was added to a solution of the compound described in Preparation 2 (50.4 g, 195.0 mmol) in ethanol (210 ml_) at 0C. The mixture was stirred at reflux for 20 hours and then partitioned between water (200 ml_) and dichloromethane (300 ml_). The aqueous layer was re-extracted with dichloromethane (100 ml_) and the combined organic solution was then dried over magnesium sulfate and concentrated under reduced pressure to afford an orange oil. A solution of the oil in dichloromethane (100 ml_) was treated with a solution of hydrogen chloride in diethyl ether (1 M, 250 ml_) and the resulting gummy precipitate was triturated with ethyl acetate to afford the title compound as a white solid in 73.2% yield, 43.5 g.1H NMR (400 MHz, CD3OD) delta: 1.32 (t, 3H), 4.11 (s, 2H), 4.31 (m, 4H), 4.47 (m, 4H), 7.51 (m, 5H); LRMS APCI m/z 268 [MH]+ |
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