Alternatived Products of [ 1377581-56-0 ]
Product Details of [ 1377581-56-0 ]
CAS No. : | 1377581-56-0 |
MDL No. : | |
Formula : |
C5H5BrN2OS
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
221.08
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1377581-56-0 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1377581-56-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1377581-56-0 ]
- 1
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[ 53159-71-0 ]
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[ 1377581-56-0 ]
Yield | Reaction Conditions | Operation in experiment |
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With hydrogen bromide; bromine; In 1,4-dioxane; water; at 60℃; for 1h; |
Intermediate 11-(2-Amino-thiazol-5-yl)-2-bromo-ethanone Bromine (0.115 mL, 2.24 mmol) in dioxane (10 mL) was added to a solution of <strong>[53159-71-0]1-(2-amino-thiazol-5-yl)-ethanone</strong> (500 mg, 2.24 mmol, prepared as described in J. Org. Chem. 1984, 49, 566) in 48% aq. HBr (10 mL) at 60 C. The resulting orange solution was stirred at this temperature for 1 h, then was added dropwise to stirred ice-cold sat. aq. NaHCO3. The mixture was extracted with EtOAc. The organic phase was dried (Na2SO4), filtered, and concentrated. The residue was purified by flash column chromatography (Silica gel, 20-60% EtOAc-Hept), affording the title compound as a white solid. |
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With bromine; In 1,4-dioxane; aq. HBr; |
1-(2-Amino-thiazol-5-yl)-2-bromo-ethanone Bromine (0.115 mL, 2.24 mmol) in dioxane (10 mL) was added to a solution of <strong>[53159-71-0]1-(2-amino-thiazol-5-yl)-ethanone</strong> (500 mg, 2.24 mmol, prepared as described in J. Org. Chem. 1984, 49, 566) in 48% aq. HBr (10 mL) at 60 C. The resulting orange solution was stirred at this temperature for 1 h, then was added dropwise to stirred ice-cold sat. aq. NaHCO3. The mixture was extracted with EtOAc. The organic phase was dried (Na2SO4), filtered, and concentrated. The residue was purified by flash column chromatography (silica gel, 20-60% EtOAc-Hept), affording the title compound as a white solid. |
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