* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With caesium carbonate In 1,2-dimethoxyethane; water at 140℃; for 0.333333 h; Microwave irradiation; Inert atmosphere
Step 3: 2-Chloro-6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[l,4]oxazino[3,4- e]purine (180 mg, 0.56 mmol) in 1 ,2-dimethoxyethane (5.1 mL) was added 5-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)pyrimidin-2-amine 25 (180 mg, 0.83 mmol) and 1.0 M of cesium carbonate in water (1.7 mL). The reaction mixture was degassed for 5 min and recycled with nitrogen atmosphere. Subsequently, l, -bis(diphenylphosphino)ferrocenepalladium(II) chloride (54 mg, 0.067 mmol) was added, and the mixture was degassed and recycled again. The reaction vial was then subjected to microwave irradiation for 20 mins at 140 °C. Solid precipitate that formed during the reaction was filtered and rinsed with excess water. The precipitate was taken up in DCM and purified by FCC (40 g, 0.5-4percent MeOH in DCM, slow gradient) to isolate103 as a tan powder (56 mg, 27percent yield). MS (ESI+): m/z 383.1 (M+H+). 1H NMR (400 MHz, DMSO) δ 9.09 (s, 2H), 7.00 (s, 2H), 4.23 (m, 4H), 4.13 (m, 4H), 3.79 - 3.68 (m, 4H), 2.50 (s, 6H)
Reference：
[1] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
[2] Patent: WO2012/82997, 2012, A1, . Location in patent: Page/Page column 91
[3] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 4, p. 351 - 356
2
[ 95758-04-6 ]
[ 1382979-44-3 ]
Reference：
[1] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 4, p. 351 - 356
[2] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
[3] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
[4] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
3
[ 1198171-66-2 ]
[ 1382979-44-3 ]
Reference：
[1] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 4, p. 351 - 356
[2] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
[3] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
[4] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
4
[ 1198171-62-8 ]
[ 1382979-44-3 ]
Reference：
[1] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 4, p. 351 - 356
[2] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
[3] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
5
[ 5451-40-1 ]
[ 1382979-44-3 ]
Reference：
[1] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
[2] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
[3] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
6
[ 20419-68-5 ]
[ 1382979-44-3 ]
Reference：
[1] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
[2] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
[3] Organic Process Research and Development, 2016, vol. 20, # 4, p. 751 - 759
With caesium carbonate;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 140.0℃; for 0.333333h;Microwave irradiation; Inert atmosphere;
Step 3: 2-Chloro-6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[l,4]oxazino[3,4- e]purine (180 mg, 0.56 mmol) in 1 ,2-dimethoxyethane (5.1 mL) was added 5-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)pyrimidin-2-amine 25 (180 mg, 0.83 mmol) and 1.0 M of cesium carbonate in water (1.7 mL). The reaction mixture was degassed for 5 min and recycled with nitrogen atmosphere. Subsequently, l, -bis(diphenylphosphino)ferrocenepalladium(II) chloride (54 mg, 0.067 mmol) was added, and the mixture was degassed and recycled again. The reaction vial was then subjected to microwave irradiation for 20 mins at 140 C. Solid precipitate that formed during the reaction was filtered and rinsed with excess water. The precipitate was taken up in DCM and purified by FCC (40 g, 0.5-4% MeOH in DCM, slow gradient) to isolate103 as a tan powder (56 mg, 27% yield). MS (ESI+): m/z 383.1 (M+H+). 1H NMR (400 MHz, DMSO) delta 9.09 (s, 2H), 7.00 (s, 2H), 4.23 (m, 4H), 4.13 (m, 4H), 3.79 - 3.68 (m, 4H), 2.50 (s, 6H)
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