There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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CAS No. : | 138642-40-7 | MDL No. : | MFCD10566526 |
Formula : | C8H7Cl2NO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 220.05 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501 | UN#: | 2811 |
Hazard Statements: | H301-H311-H331 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
To a stirred solution of methyl 2,4-dichloro-6-methylnicotinate (45g, 0.19 mol) in dry CH2CI2 (450 ml.) was added DIBAL-H (1 M solution in toluene) (576 mL, 0.57 mol) at -78 C over a period of 30 minutes. The stirring was continued for another 2 h at -78 C. The reaction mixture was quenched with saturated NH4CI solution (100 mL) at the same temperature and allowed to warm to room temperature. The reaction mixture was diluted with 0.2 N HCI solution (1000 mL), extracted with CH2CI2 (3 x 500 mL), the combined organics were washed with H20 (2 x 200 mL), brine solution (2 x 250 mL), dried (Na2S04) and concentrated. The crude compound was purified by flash column chromatography (silica gel, 100-200 mesh) and the desired aldehyde (XX) eluted with 5% EtOAc-pet ether to afford 16 g as an off-white solid. Rf: 0.6 (20% EtOAc/pet ether). (2,4-dichloro-6- methylpyridin-3-yl)methanol was eluted at 15% EtOAc-pet ether to afford 15g as an off- white solid. Rf: 0.25 (20% EtOAc/pet ether), over all yield (31 g, 84%). |