Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 139487-11-9 | MDL No. : | MFCD17015861 |
Formula : | C11H12INO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 301.12 | Pubchem ID : | - |
Synonyms : |
|
Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74% | With potassium hydroxide; In dimethyl sulfoxide; at 20.0℃; for 0.5h; | 5-Iodo-indolin-2-one 7a (50 mg, 193 mumol) and methyl iodide (72.1 muL, 1.16 mmol, 6 equiv) were added to a vigorously stirred solution of KOH (45.1 mg, 0.80 mmol, 4 equiv) in DMSO (2 mL) at room temperature. The reaction was monitored by TLC until complete consumption of 7a (30 min). After water addition, the reaction mixture was extracted with ethyl acetate and the organic layer dried over Na2SO4. Solvent was then evaporated under reduced pressure and the 5-iodo-1,3,3-trimethylindolin-2-one 8a was purified using preparative thin layer chromatography [light petroleum/ethyl acetate (3:2)]. Crystallization from dichloromethane/light petroleum afforded 8a in 74% yield (43 mg). |