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[ CAS No. 1415899-20-5 ] {[proInfo.proName]}

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Chemical Structure| 1415899-20-5
Chemical Structure| 1415899-20-5
Structure of 1415899-20-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1415899-20-5 ]

CAS No. :1415899-20-5 MDL No. :
Formula : C11H12BrNO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 286.12 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1415899-20-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1415899-20-5 ]

[ 1415899-20-5 ] Synthesis Path-Downstream   1~3

  • 2
  • [ 1159599-99-1 ]
  • [ 1415899-20-5 ]
  • 6-(cyclopropylmethoxy)-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyridine-2-carboxylic acid methyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
73% With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 110℃;Inert atmosphere; Under a nitrogen atmosphere a mixture of compound methyl 5-bromo-6- (0208) (cyclopropylmethoxy)pyridine-2-carboxylate (CAN 1415899-20-5, 0.51 g, 1.8 mmol), 2- oxa-6-azaspiro[3.3]heptane ethanedioate (CAN 1254966-66-9, 0.29 mg, 1.8 mmol), Pd2(dba)3 (33 mg, 0.035 mmol), BINAP (45 mg, 0.07 mmol) and Cs2C03 (1.76 mg, 5.4 mmol) in toluene (50 mL) was stirred at 110 C overnight. After concentration, the residue was partitioned between water (30 mL) and EtOAc (30 mL). The aqueous phase was extracted with EtOAc (2x20 mL). The combined organic phase was washed with brine (30 mL), dried over anhydrous Na2S04, filtered and concentrated to give a residue which was purified by column chromatography eluting with petroleum ether - ethyl acetate (1: 1) to give the target compound (0.4 g, 73%) as yellow solid, LC-MS: 305.1 [MH+] .
  • 3
  • [ 1159599-99-1 ]
  • [ 1415899-20-5 ]
  • 6-(cyclopropylmethoxy)-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyridine-2-carboxylic acid [ No CAS ]
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