Alternatived Products of [ 141602-36-0 ]
Product Details of [ 141602-36-0 ]
CAS No. : | 141602-36-0 |
MDL No. : | MFCD09909760 |
Formula : |
C5HCl2F3N2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
216.98
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 141602-36-0 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 141602-36-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 141602-36-0 ]
- 1
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[ 141602-36-0 ]
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[ 153122-60-2 ]
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dichlorobis(triphenylphosphine)palladium[II]
[ No CAS ]
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5-chloro-4-(4-chloro-2-fluoro-5-methoxyphenyl)-6-trifluoromethylpyrimidine
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; |
(1) 4,5-Dichloro-6-trifluoromethylpyrimidine (1.3g, 6mmol), <strong>[153122-60-2]4-chloro-2-fluoro-5-methoxyphenylboronic acid</strong> (1.29g, 6.3mmol), dichlorobis (triphenylphosphine) palladium(II) (0.29g, 6.3mmol) and sodium hydrogencarbonate (1.64g, 20mmol) were added to a mixture of dimethoxyethane (50ml) and water (10ml). The resulting mixture was refluxed for 2 hours. After cooling, the reaction mixture was adjusted to pH 4 with 1N-hydrochloric acid and then concentrated. Water (60ml) was added to the residue, and the mixture was extracted with chloroform, washed with water, dried, and then concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=10:1) to give 5-chloro-4-(4-chloro-2-fluoro-5-methoxyphenyl)-6-trifluoromethylpyrimidine (1.42g, compound no. A-1). m.p.:109-111ØC 1H-NMR(CDCl3) delta 3.94(3H, s), 7.01(1H, d, J=6.0Hz), 7.31(1H, d, J=9.0Hz), 9.28(1H, s). 19F-NMR(CDCl3) delta -68.1, -120.2. |