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[ CAS No. 14164-34-2 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

2D 3D

Chemical Structure| 14164-34-2

Chemical Structure| 14164-34-2

Structure of 14164-34-2 * Storage: {[proInfo.prStorage]}

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Quality Control of [ 14164-34-2 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 14164-34-2 ]

SDS Specification

Alternatived Products of [ 14164-34-2 ]

Product Details of [ 14164-34-2 ]

CAS No. :	14164-34-2	MDL No. :	MFCD01436254
Formula :	C₁₂H₁₂N₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	184.24	Pubchem ID :	-
Synonyms :

Safety of [ 14164-34-2 ]

Signal Word:		Class:
Precautionary Statements:		UN#:
Hazard Statements:		Packing Group:

Application In Synthesis of [ 14164-34-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 14164-34-2 ]
Downstream synthetic route of [ 14164-34-2 ]

[ 14164-34-2 ] Synthesis Path-Upstream 1~9

1
[ 1134-81-2 ]
[ 288-13-1 ]
[ 13036-57-2 ]
[ 4472-44-0 ]
[ 14164-34-2 ]

Reference： [1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 24, p. 3581 - 3585

2
[ 1134-81-2 ]
[ 13036-57-2 ]
[ 4472-44-0 ]
[ 14164-34-2 ]
[ 1453-58-3 ]

Reference： [1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 24, p. 3581 - 3585

3
[ 1134-81-2 ]
[ 67-66-3 ]
[ 13036-57-2 ]
[ 4472-44-0 ]
[ 7431-45-0 ]
[ 14164-34-2 ]

Reference： [1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 24, p. 3581 - 3585

4
[ 1134-81-2 ]
[ 67-66-3 ]
[ 13036-57-2 ]
[ 4472-44-0 ]
[ 14164-34-2 ]
[ 1453-58-3 ]

Reference： [1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 24, p. 3581 - 3585

5
[ 1134-81-2 ]
[ 288-13-1 ]
[ 13036-57-2 ]
[ 4472-44-0 ]
[ 14164-34-2 ]

Reference： [1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 24, p. 3581 - 3585

6
[ 1134-81-2 ]
[ 13036-57-2 ]
[ 4472-44-0 ]
[ 14164-34-2 ]
[ 1453-58-3 ]

Reference： [1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 24, p. 3581 - 3585

7
[ 1134-81-2 ]
[ 67-66-3 ]
[ 13036-57-2 ]
[ 4472-44-0 ]
[ 7431-45-0 ]
[ 14164-34-2 ]

Reference： [1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 24, p. 3581 - 3585

8
[ 1134-81-2 ]
[ 67-66-3 ]
[ 13036-57-2 ]
[ 4472-44-0 ]
[ 14164-34-2 ]
[ 1453-58-3 ]

Reference： [1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 24, p. 3581 - 3585

9
[ 1134-81-2 ]
[ 67-66-3 ]
[ 13036-57-2 ]
[ 4472-44-0 ]
[ 7431-45-0 ]
[ 14164-34-2 ]

Reference： [1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 24, p. 3581 - 3585

[ 14164-34-2 ] Synthesis Path-Downstream 1~1

1
[ 3102-33-8 ]
[ 618-39-3 ]
[ 14164-34-2 ]

Yield	Reaction Conditions	Operation in experiment
55%	With oxygen; triethylamine In acetonitrile at 80℃; for 9h;	General Procedure for the Synthesis of PyrimidineDerivatives General procedure: A round bottom flask was charged with the substitutedchalcone 1 (1.0 mmol), benzamidine 2 (1.0 mmol), triethylamine(2.0 mmol) and acetonitrile (10 mL). The mixturewas heated to 80 °C for 4-14 h, and then cooled to r.t.Evaporation of the solvent gave a crude reaction mixture, towhich water (10 mL) was added and the resulting mixturewas extracted with EtOAc (3 20 mL). The combined organiclayer was washed with 1N HCl (20 mL), brine anddried over anhydrous Na2SO4. The solvent was concentratedunder reduced pressure and residue obtained was purified bysilica gel column chromatography (100-200 mesh) using nhexane:Et2O (95:05) as the eluent to afford the correspondingpyrimidine 3.

Reference： [1]Vadagaonkar, Kamlesh S.; Kalmode, Hanuman P.; Murugan, Kaliyappan; Chaskar, Atul C. [Letters in Organic Chemistry, 2015, vol. 12, # 7, p. 447 - 458]

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
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Code	Phrase
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P233	Keep container tightly closed.
P234	Keep only in original container.
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P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
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Code	Phrase
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P320
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P321
P322
P330	Rinse mouth.
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P337	If eye irritation persists:
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P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
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P378
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P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
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P501	Dispose of contents/container to ...
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Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
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H242	Heating may cause a fire
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H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
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Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
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H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
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H402	Harmful to aquatic life
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