Alternatived Products of [ 1416800-51-5 ]
Product Details of [ 1416800-51-5 ]
CAS No. : | 1416800-51-5 |
MDL No. : | MFCD30828946 |
Formula : |
C10H13BrN2OS
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
289.19
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1416800-51-5 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1416800-51-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1416800-51-5 ]
- 1
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[ 343338-28-3 ]
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[ 405174-97-2 ]
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[ 1416800-51-5 ]
Yield | Reaction Conditions | Operation in experiment |
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With copper(II) sulfate; In dichloromethane; at 20℃; |
Step 3. (S,E)-N-((3-Bromopyridin-2-yl)methylene)-2-methylpropane-2- sulflnamideA mixture of 3-bromo piconaldehyde (10 g, 53.8 mmol), copper sulfate (3.98 mL, 81 mmol) and (5)-2-methylpropane-2-sulfinamide (6.84 g, 56.4 mmol) in DCM (100 mL) was stirred at rt overnight. The solid was filtered off and the filtrate concentrated under vacuum. The residue thus obtained was purified by column chromatography using silica (100-200 mesh) with 20% EtOAc in n- hexane as eluent to give (S,E)-N-((3-bromopyridin-2-yl)methylene)-2- methylpropane-2-sulfinamide as yellow oil. 1H-NMR (400 MHz, CDC13): delta ppm 9.0 (s, 1H), 8.75 (d, 1H), 7.97 (d, 1H), 7.32 (t, 1H), 5.2 (d, 1H), 1.3 (s, 9H). |
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copper(II) sulfate; In dichloromethane; at 20℃; |
Step 3. (S,E)-N-((3-Bromopyridin-2-yl)methylene)-2-methylpropane-2- sulflnamideA mixture of 3-bromo piconaldehyde (10 g, 53.8 mmol), copper sulfate (3.98 mL, 81 mmol) and (5)-2-methylpropane-2-sulfinamide (6.84 g, 56.4 mmol) in DCM (100 mL) was stirred at rt overnight. The solid was filtered off and the filtrate concentrated under vacuum. The residue was purified by column chromatography using silica (100-200 mesh) with 20% EtOAc in n-hexane as eluent to give (S,E)-N-((3-bromopyridin-2-yl)methylene)-2-methylpropane-2- sulfinamide as yellow oil. 1H-NMR (400 MHz, CDC13): 9.0(s, 1H), 8.74-8.76(d, 1H), 7.9-8.04(d, 1H), 7.26-7.38(t 1H), 5.2(d, 1H), 1.3(s, 9H). |
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