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Chemical Structure| 1427012-87-0 Chemical Structure| 1427012-87-0

Structure of 1427012-87-0

Chemical Structure| 1427012-87-0

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Product Details of [ 1427012-87-0 ]

CAS No. :1427012-87-0
Formula : C9H7ClN2
M.W : 178.62
SMILES Code : N#CC1(C2=NC=C(Cl)C=C2)CC1
MDL No. :MFCD23134905

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Application In Synthesis of [ 1427012-87-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1427012-87-0 ]

[ 1427012-87-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1480-65-5 ]
  • [ 5500-21-0 ]
  • [ 1427012-87-0 ]
YieldReaction ConditionsOperation in experiment
31% With potassium hexamethylsilazane; In toluene; at 0 - 22℃; for 3.25h; To a solution of <strong>[1480-65-5]5-chloro-2-fluoropyridine</strong> (2 g, 1.53 ml, 15.2 mmol, Eq: 1.00) and cyclopropanecarbonitrile (1.02 g, 1.15 ml, 15.2 mmol, Eq: 1.00) in toluene (20.0 ml) wasadded dropwise over 5 mi KHMDS 0.5 M in toluene (30.4 ml, 15.2 mmol, Eq: 1.00) at0°C. The solution turned brown. After 45 mm, the reaction mixture was allowed to warm up to 22 °C and stuffed for 2.5 h. Saturated aqueous NH4C1 solution (50 ml) was then added and the aqueous phase was extracted with AcOEt (3 x 60 ml). The combined organic phases were dried over Na2504, filtered and concertrated under reduced pressure.The crude material was purified by flash chromatography (silica gel, 70 g, 0percent to 20percent EtOAc in heptane) to yield the title compound as a white solid (840 mg; 31 percent). mlz = 179.0373 [M+Hf?.
 

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