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(9H-Fluoren-9-yl)methyl ((S)-1-(((S)-6-((tert-butoxycarbonyl)amino)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxohexan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
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[ CAS No. 1432969-78-2 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1432969-78-2
Chemical Structure| 1432969-78-2
Structure of 1432969-78-2 * Storage: {[proInfo.prStorage]}
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Quality Control of [ 1432969-78-2 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification
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Product Details of [ 1432969-78-2 ]

CAS No. :1432969-78-2 MDL No. :N/A
Formula : C38H48N4O7 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 672.81 Pubchem ID :-
Synonyms :

Safety of [ 1432969-78-2 ]

Signal Word: Class:N/A
Precautionary Statements: UN#:N/A
Hazard Statements: Packing Group:N/A

Application In Synthesis of [ 1432969-78-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1432969-78-2 ]

[ 1432969-78-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 130878-68-1 ]
  • [ 1432969-78-2 ]
Reference： [1]Patent: WO2013/67597,2013,A1
  • 2
  • [ 1432969-78-2 ]
  • [ 1432969-86-2 ]
YieldReaction ConditionsOperation in experiment
65% With diethylamine In dichloromethane; acetonitrile at 0 - 20℃; for 17h; 4 Preparation of PEG-A Preparation of PEG-A A 1 L round-bottomed flank was charged with PEG-A-4 (4.5 g, 6.68 mmol), diethylamine (7.33 g, 100.2 mmol), DCM (200 mL), MeCN (200 mL). The mixture was stirred at 0°C for 2 hrs, then stirred at r.t. for 15 hrs. TLC showed the starting material was trace, the mixture was washed with iN aq. HC1, 1120 and dried over Na2SO4. The solvent was evaporated and the residue was purified by columnchromatography to give PEG-A (1.5 g, 65%).
With piperidine In N,N-dimethyl-formamide at 20℃; for 0.166667h; 7-1 Deprotection Substrate (716 mg, 1.06 mmol) dissolved in 5 mL of a 20% piperidine in DMF solution. The reaction was stirred for 10 minutes at room temperature. Complete conversion was observed by UPLC-MS. The reaction was concentrated in vacuo, and used in the next step without further purification. Rt = 0.94 min General Method UPLC. MS (m/z) [M + H]+ calc for C23H39N4O5 451.29, found 450.72.
Reference： [1]Current Patent Assignee: ASCEND BIOPHARMACEUTICALS - WO2013/67597, 2013, A1 Location in patent: Page/Page column 82
[2]Current Patent Assignee: SEAGEN INC - WO2019/195665, 2019, A1 Location in patent: Paragraph 0374
  • 3
  • C18H29N3O4 [ No CAS ]
  • [ 130878-68-1 ]
  • [ 1432969-78-2 ]
YieldReaction ConditionsOperation in experiment
716 mg With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.5h; Crude substrate (1.07 mmol) from previous step was dissolved in DMF (2 mL). Fmoc- Val-OSu (581 mg , 1.33 mmol) added followed by DIPEA (0.37 mL, 2.13 mmol) and stirred for 30 minutes. Complete conversion was observed by UPLC-MS. The reaction was quenched with AcOH, concentrated in vacuo, and purified by FCC 100G KP-Sil 0-10% MeOH in DCM. (0855) Fractions containing the desired product were concentrated in vacuo to afford a white solid (716 mg, 1.06 mmol, 99%). Rt = 2.12 min General Method UPLC. MS (m/z) [M + H]+ calc for C38H49N4O7 673.36, found 673.31.
Reference： [1]Patent: WO2019/195665,2019,A1 .Location in patent: Paragraph 0373

Tags: 1432969-78-2 synthesis path| 1432969-78-2 SDS| 1432969-78-2 COA| 1432969-78-2 purity| 1432969-78-2 application| 1432969-78-2 NMR| 1432969-78-2 COA| 1432969-78-2 structure

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