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[ CAS No. 1442470-52-1 ] {[proInfo.proName]}

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Chemical Structure| 1442470-52-1
Chemical Structure| 1442470-52-1
Structure of 1442470-52-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1442470-52-1 ]

CAS No. :1442470-52-1 MDL No. :
Formula : C16H12BrClFN3O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 396.64 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1442470-52-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1442470-52-1 ]

[ 1442470-52-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 959163-01-0 ]
  • [ 1442471-26-2 ]
  • [ 1442470-52-1 ]
YieldReaction ConditionsOperation in experiment
89% With aluminum oxide; potassium fluoride In N,N-dimethyl acetamide for 2h; Sonication; A13 Example A13 A mixture of Example C5 (2.191 g, 7.94 mmol), Example B1 (1.538 g, 8.33 mmol) and KF on alumina (40 wt %) (9.22 g, 63.5 mmol) in DMA (40 mL) was sonicated for 2 h. The mixture was filtered through a shallow bed of silica gel and rinsed well with EtOAc. The filtrate was washed with satd. NaHCO3 (1*), 5% LiCl (2*), then brine (1*), dried (MgSO4), and concentrated to dryness to afford 3-(5-amino-2-bromo-4-fluorophenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one (2.793 g, 89% yield) as a brown solid. 1H NMR (400 MHz, DMSO-d6): δ 8.77 (s, 1H), 8.00 (s, 1H), 7.74 (s, 1H), 7.37 (d, 1H), 6.77 (d, 1H), 5.45 (s, 2H), 4.27 (q, 2H), 1.20 (t, 3H); MS (ESI) m/z: 398.0 [M+H]+.
89% With 40% potassium fluoride/alumina In N,N-dimethyl acetamide for 2h; Sonication; A13 Example A13: A mixture of Example CS (2.191 g, 7.94 mmol), Example B1(1.538 g, 8.33 mmol) and KF on alumina (40 wt%) (9.22 g, 63.5 mmol) in DMA (40 mL)was sonicated for 2 h. The mixture was filtered through a shallow bed of silica gel and rinsedwell with EtOAc. The filtrate was washed with satd. NaHC03 (1x), 5% LiCl (2x), then brine(1x), dried (MgS04), and concentrated to dryness to afford 3-(5-amino-2-bromo-4-fluorophenyl)-7 -chloro-1-ethyl-1 ,6-naphthyridin-2(1H)-one (2. 793 g, 89% yield) as a brownsolid. 1H NMR (400 MHz, DMSO-d6): 8 8.77 (s, 1 H), 8.00 (s, 1 H), 7.74 (s, 1 H), 7.37 (d, 1H), 6.77 (d, 1 H), 5.45 (s, 2 H), 4.27 (q, 2 H), 1.20 (t, 3 H); MS (ESI) m/z: 398.0 [M+Ht.
  • 2
  • [ 61150-59-2 ]
  • [ 1442470-52-1 ]
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