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Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / toluene / 12 h / 80 °C
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(I) bromide; potassium carbonate / N,N-dimethyl-formamide; water / 0.5 h / 120 °C
3.1: hydrogenchloride / water / 0.5 h / 100 °C
3.2: 20 °C
3.3: 12 h / 20 °C
Multi-step reaction with 2 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(I) bromide; potassium carbonate / N,N-dimethyl-formamide; water / 0.5 h / 120 °C
2.1: hydrogenchloride / water / 0.5 h / 100 °C
2.2: 20 °C
2.3: 12 h / 20 °C
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 12 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine / toluene / 12 h / 80 °C
3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(I) bromide; potassium carbonate / N,N-dimethyl-formamide; water / 0.5 h / 120 °C
4.1: hydrogenchloride / water / 0.5 h / 100 °C
4.2: 20 °C
4.3: 12 h / 20 °C
Stage #1: 4-((5-(5-(1,3-dioxolan-2-yl)pyridin-2-yl)-2-(butylamino)pyrimidin-4-yl)amino)cyclohexanol With hydrogenchloride In water at 100℃; for 0.5h;
Stage #2: morpholine With sodium tris(acetoxy)borohydride In dichloromethane at 20℃;
Stage #3: With hydrogenchloride In methanol at 20℃; for 12h;