Alternatived Products of [ 153248-47-6 ]
Product Details of [ 153248-47-6 ]
CAS No. : | 153248-47-6 |
MDL No. : | MFCD24465661 |
Formula : |
C10H17NO3
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
199.25
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 153248-47-6 ]
Application In Synthesis of [ 153248-47-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 153248-47-6 ]
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[ 153248-46-5 ]
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[ 153248-47-6 ]
Yield | Reaction Conditions | Operation in experiment |
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Under an argon atmosphere oxalyl chloride (1.17 mL, 13.8 mmol) was dissolved in DCM (30 mL) and cooled to -70 C. DMSO (1.95 mL, 27.6 mmol) in DCM (2.5 mL) was added over 5 min and stirred for 10 min. (1-Hydroxymethyl- cyclopropylmethyl)-carbamic acid tert-butyl ester (2.6g, 12 mmol) in DCM (8.5 mL) was added at -70 C over 5 min and the mixture was stirred for 30 min. Et3N (6.4 mL, 45.6 mmol) was added over 5 min and the temperature was allowed to reach RT over 1 h. H2O was added and the aqueous phase was extracted with DCM (x 2). The combined organic phases were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The crude product was purified by flash chromatography on silica using heptane : EtOAc 1 : 15 as eluent to afford (l-Formyl-cyclopropylmethyl)-carbamic acid tert-butyl ester (0.65g)as an oil. |
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With pyridinium chlorochromate; In dichloromethane; at 25℃; for 2h; |
To a solution of tert-butyl ((1 -(hydroxymethyl)cyclopropyl)methyl)carbamate (1 equiv.) in dichloromethane at 25 C was added PCC (1.15 equiv.) in a single portion. Reaction was stirred for 2 h. Diethyl ether was added to the vessel, and the heterogeneous mixture was filtered through silica gel to yield the desired aldehyde intermediate, which was used without further purification. |