Alternatived Products of [ 155852-41-8 ]
Product Details of [ 155852-41-8 ]
CAS No. : | 155852-41-8 |
MDL No. : | MFCD16293816 |
Formula : |
C11H12O3
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
192.21
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 155852-41-8 ]
Signal Word: | Warning |
Class: | N/A |
Precautionary Statements: | P305+P351+P338-P280 |
UN#: | N/A |
Hazard Statements: | H319-H317 |
Packing Group: | N/A |
GHS Pictogram: |
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Application In Synthesis of [ 155852-41-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 155852-41-8 ]
- 1
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[ 67-56-1 ]
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[ 69999-16-2 ]
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[ 155852-41-8 ]
Yield | Reaction Conditions | Operation in experiment |
93% |
With thionyl chloride; at 80℃; for 0.333333h; |
<strong>[69999-16-2]2-(dihydrobenzofuran-5-yl)acetic acid</strong> (1A) (5.0 g, 28 mmol) was dissolved in anhydrous methanol (20 mL) was slowly added dropwise thionyl chloride (10.0g, 84mmol), after addition the reaction was heated to 80 C for 20 min. Ice bath cooling, add water (30 mL), ethyl acetate (100 mL), dispensing, the organic layer was washed with saturated sodium chloride solution (30 mL x 3) dried over anhydrous sodium sulfate, filter, the filtrate was concentrated under reduced pressure to give the title compound 2-(2,3-dihydrobenzofuran-5-yl acetate (1B), a light yellow oil (5.0 g, 93% yield). |
93% |
With sulfuric acid; at 70℃; for 2.0h; |
To a solution of <strong>[69999-16-2]2-<strong>[69999-16-2](2,3-dihydrobenzofuran-5-yl)acetic acid</strong></strong> (4 g, 22.4 mmol) in methanol (40 mL) was added sulfuric acid (219 mg, 2.24 mmol). The reaction mixture was heated to 70 C. and stirred at that temperature for 2 h. The mixture was concentrated and the residue was added ethyl acetate (50 mL). The solution was washed with brine, then the organic phase was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to provide methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate (4.0 g, yield: 93%) as a yellow oil. MS(ESI): m/z 193 [M+H]+. |
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With sulfuric acid; for 3.0h;Heating / reflux; |
Example 9; Preparation of 2(2,3-Dihvdrobenzofura-5-v)acetic acid, methyl ester; [00155] 98% H2SO4 (2g) was added to a solution of 2(2,3-Dihydrobenzofura-5- y)acetic acid (20Og) in MeOH (500ml), and the mixture was refluxed for 3hrs (TLC: SiO2, toluene/ AcOEt 8:2; starting material not detected). After cooling to room temperature, NaHCO3 (6.7g) was added to the reaction mixture, and the solvent was distilled off at atmospheric pressure (about 440 ml), to give a light pink oily residue.[00156] The oily residue was dissolved in toluene (250 ml), and washed with NaHCO36% (50 ml). After the phases were separated, the solvent was eliminated under vacuum distillation to obtain a light pink oily residue (227 g). |
- 2
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[ 155852-41-8 ]
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[ 69999-16-2 ]
Yield | Reaction Conditions | Operation in experiment |
79.8% |
With water; sodium hydroxide; In methanol; at 25 - 60℃; |
Residue obtained in Example 6 (compound 17)119 g (619.1 mmol) was dissolved with 480 g of methanol;An aqueous solution containing 30 g (750 mmol) of sodium hydroxide was added dropwise at a temperature of 25 to 30C under controlled temperature.Heat to 55~60C for 2~4hr.After confirming the reaction,Concentrate methanol under reduced pressure400g water was added to the residue,Stir and dissolve.At a controlled temperature, about 80 g (about 800 mmol) of concentrated hydrochloric acid is added dropwise at 25 to 30C.Precipitation of solids,After cooling and crystallization,filter,88g solid (theory Quantity: 110.32g);Yield: 79.8%. |
- 3
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[ 155852-41-8 ]
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[ 127264-14-6 ]