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With potassium carbonate In N,N-dimethyl-formamide at 80℃; Inert atmosphere;
6.1 Step 1
under argon atmosphere, 1 mmol PTC596, 1 mmolBromopropyne and 2mmol of potassium carbonate were dissolved in DMF and reacted at 80°C for 10-16h,After the reaction, the reaction solution was diluted with the solvent of equal volume of ethyl acetate and water,The organic layer was separated, the aqueous phase was extracted with ethyl acetate, the organic layers were combined,And dry with anhydrous sodium sulfate, remove the solvent, column chromatography analysis to obtain pure substance,The yield was 46.7%. Named PTC-alkyne.