Alternatived Products of [ 161563-79-7 ]
Product Details of [ 161563-79-7 ]
CAS No. : | 161563-79-7 |
MDL No. : | MFCD03086213 |
Formula : |
C7H8N4OS
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
196.23
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 161563-79-7 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 161563-79-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 161563-79-7 ]
- 1
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[ 57626-37-6 ]
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[ 161563-79-7 ]
Yield | Reaction Conditions | Operation in experiment |
89% |
With hydrazine hydrate; In ethanol; for 3h;Reflux; |
To the stirred solution of <strong>[57626-37-6]ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate</strong> (2a) (5.20 g) in ethanol (40 mL) was added 35%aqueous solution of N2H4H2O (40 mL) and refluxed for 3 h. Thereaction mixture was concentrated to half volume and cooled onice bath, the solids formed were filtered and dried in vacuum ovento get 6-methylimidazo[2,1-b]thiazole-5-carbohydrazide (3a)(4.30 g, 89%) as an Off-white solid. ESI-MS showed 197 [M+H]+. |
- 2
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[ 2215-77-2 ]
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[ 161563-79-7 ]
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6-methyl-N'-(4-phenoxybenzoyl)imidazo[2,1-b]thiazole-5-carbohydrazide
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
88% |
Stage #1: 4-Phenoxybenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃;
Stage #2: 6-methylimidazo-<2,1-b>thiazole-5-carbohydrazide In dichloromethane at 20℃; for 3h; |
10 4.1.7. General procedure for the synthesis of final molecules(5aa-ae and 5ba-be)
General procedure: To the stirred solution of R-COOH (1.0 equiv), in CH2Cl2 at 0 Cwas added EDCI (1.2 equiv), HOBt (1.2 equiv) and Et3N (2.0 equiv)stirred for few minutes then was added 6-methylimidazo[2,1-b]thiazole-5-carbohydrazide (for 5aa-ae)/2-methylbenzo[d]imidazo[2,1-b]thiazole-3-carbohydrazide (for 5ba-be) (1.2 equiv), andallowed stir at rt for 3 h, The reaction mixture was diluted withCH2Cl2 and washed with H2O and the separated organic layerwas concentrated under reduced pressure, purified by columnchromatography. |
Reference:
[1]Samala, Ganesh; Devi, Parthiban Brindha; Saxena, Shalini; Meda, Nikhila; Yogeeswari, Perumal; Sriram, Dharmarajan
[Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 6, p. 1298 - 1307]