Alternatived Products of [ 162435-06-5 ]
Product Details of [ 162435-06-5 ]
CAS No. : | 162435-06-5 |
MDL No. : | MFCD22381043 |
Formula : |
C9H9N3
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
159.19
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 162435-06-5 ]
Application In Synthesis of [ 162435-06-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 162435-06-5 ]
- Downstream synthetic route of [ 162435-06-5 ]
- 1
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[ 75415-03-1 ]
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[ 74-88-4 ]
-
[ 162435-06-5 ]
Yield | Reaction Conditions | Operation in experiment |
94% |
|
To a solution of <strong>[75415-03-1]3-(2-pyridyl)pyrazol</strong>e (291 mg, 2 mmol) in THF (20 mL) was added NaH (0.3 g, 12.5 mmol). The mixture was stirred for lh and the Mel (568 mg, 4 mmol) was added in one portion. The reaction mixture was stirred for 18h at room temperature. The reaction was quenched with MeOH and the solvent was removed in vacuo. The residue was treated with water and EtOAc. The organic layer was separated and the aqueous layer was extracted with EtOAc. The combined organic phase was dried over Na2S04, filtered, and concentrated to give crude product. The crude product was purified on ISCO columns. Fractions containing pure product were combined and evaporated to give 3-(2-pyridyl)-l-methylpyrazole (300 mg, 94%) as a yellow oil. |
Reference:
[1]Journal of the American Chemical Society,2017,vol. 139,p. 17186 - 17192
[2]Patent: WO2014/59333,2014,A1 .Location in patent: Paragraph 00485
[3]Organometallics,2020,vol. 39,p. 217 - 226
[4]Dalton Transactions,2014,vol. 43,p. 1524 - 1533
[5]Chemische Berichte,1994,vol. 127,p. 2373 - 2380
[6]ChemSusChem,2017,vol. 10,p. 4535 - 4543
- 2
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[ 60-34-4 ]
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[ 75415-00-8 ]
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[ 938066-21-8 ]
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[ 162435-06-5 ]
- 3
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[ 66521-54-8 ]
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[ 60-34-4 ]
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[ 938066-21-8 ]
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[ 162435-06-5 ]
- 4
-
[ 13737-04-7 ]
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[ 151049-87-5 ]
-
[ 162435-06-5 ]
Yield | Reaction Conditions | Operation in experiment |
66%Chromat. |
With potassium fluoride; copper(l) iodide; palladium diacetate; catacxium A; In N,N-dimethyl-formamide; at 90℃; for 12h;Inert atmosphere; |
General procedure: 2-Trimethylsilylpyridine (1.2mmol), the aryl halide (1mmol), palladium acetate (0.10mmol), CataXCium A (0.2mmol), CuI (76mg, 0.4mmol) and KF (2.20mmol) were combined in reaction tubes in a Radleys green-house parallel synthesiser under a flow of nitrogen and degassed DMF (1ml) was added. The resulting suspensions were stirred at 90 oC under nitrogen for 12 hours. Reactions were analysed by LC-MS at 1mg/1ml in methanol to determine the yield. |