Alternatived Products of [ 16308-63-7 ]
Product Details of [ 16308-63-7 ]
CAS No. : | 16308-63-7 |
MDL No. : | MFCD27578763 |
Formula : |
C22H18O4
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
346.38
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 16308-63-7 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 16308-63-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 16308-63-7 ]
- 1
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[ 18014-00-1 ]
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[ 98-80-6 ]
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[ 16308-63-7 ]
Yield | Reaction Conditions | Operation in experiment |
80% |
With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In water; toluene; for 8h;Heating / reflux; |
In a stream of argon, 35 g (0.1 mol) of <strong>[18014-00-1]methyl 2,5-dibromoterephthalate</strong>, 27 g (0.22 mol) of phenylboronic acid, 5.7 g (5 mmol) of tetrakistriphenylphosphinepalladium(0), 200 mL of toluene, and the mixture of 32 g (0.3 mol) of sodium carbonate and 150 mL of water were added to a 1-L three-necked flask, and the whole was refluxed under heat for 8 hours. After the completion of the reaction, an organic layer was washed with water and dried with magnesium sulfate, and then the solvent was removed by distillation with a rotary evaporator. The resultant coarse crystal was recrystallized with ethanol, whereby 27 g of Intermediate 1 (white crystal, 80% yield) as a target were obtained. |
80% |
With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In water; toluene; for 8h;Reflux; Inert atmosphere; |
Synthesis Example 1(101) Synthesis of Intermediate 1; Into a 1 liter three-necked flask, 35 g (0.1 mole) of <strong>[18014-00-1]di<strong>[18014-00-1]methyl 2,5-dibromoterephthalate</strong></strong>, 27 g (0.22 moles) of phenyl boronic acid, 5.7 g (5 mmole) of tetrakis(triphenylphosphine)palladium(0), 200 ml of toluene and a solution prepared by dissolving 32 g (0.3 moles) of sodium carbonate into 150 ml of water were placed under the stream of argon, and the resultant mixture was heated under the refluxing condition for 8 hours. After the reaction was completed, the organic layer was washed with water and dried with magnesium sulfate, and the solvent was removed by distillation using a rotary evaporator. The obtained crude crystals were recrystallized from ethanol, and 27 g of Intermediate 1 of the object compound was obtained (white crystals; the yield: 80%). |
- 2
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[ 16308-63-7 ]
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[ 486-52-2 ]
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