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CAS No. : | 163521-19-5 | MDL No. : | MFCD09833264 |
Formula : | C26H26N4O3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 442.51 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | With N,N-diethyl-N-isopropylamine; 2-chloro-1-methyl-pyridinium iodide; ammonia In 1-methyl-pyrrolidin-2-one |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
4 Example 4 Example 4 Analogously to Example 3, starting from 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carboxybenzofuran-5-yl)piperazine reaction with 2-chloro-l-methylpyridinium methanesulfonate gives 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine, m.p. 269-272° (hydrochloride). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90.1% | Stage #1: 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}benzofuran-2-carboxylic acid With 2-chloro-1-methyl-pyridinium iodide; triethylamine In dimethyl sulfoxide at 40 - 50℃; for 1h; Stage #2: With ammonium bromide In dimethyl sulfoxide at 40 - 70℃; for 0.5h; Stage #3: With hydrogenchloride In water; ethyl acetate at 0 - 10℃; for 1h; | 1-4 Example 3 The compound of formula II (300 g, 677.9 mmol) was dissolved in DMSO (3000 mL). Stirring at 40 to 50 ° C, Add CMPI (518.62g, 2.03mol), TEA (205.42g, 2.03mol), Stir for 1 hour with heat. Ammonium bromide (996.05 g, 10.17 mol) was added, and the mixture was heated to 60 to 70 ° C for 0.5 hour. After the reaction, Water (6000 mL) was added to the reaction solution. A large amount of off-white solid was precipitated. After suction filtration, the filter cake was added to ethyl acetate (80000 mL), stirred and heated to reflux, and dissolved. Add hydrochloric acid Ethyl acetate solution (3mol/L, 453mL), Stirring at 010°C for 1 hour, Filtering, The filter cake was rinsed with ethyl acetate (1000 mL). And dried under vacuum at 60-70 ° C, obtain Vilazodone hydrochloride, The yield was 90.1%, and the purity was 99.47%. |