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[ CAS No. 166386-69-2 ] {[proInfo.proName]}

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Chemical Structure| 166386-69-2
Chemical Structure| 166386-69-2
Structure of 166386-69-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 166386-69-2 ]

CAS No. :166386-69-2 MDL No. :MFCD20133980
Formula : C8H5BrO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 213.03 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 166386-69-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 166386-69-2 ]

[ 166386-69-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 7017-48-3 ]
  • [ 166386-69-2 ]
YieldReaction ConditionsOperation in experiment
68% 2-(5-Bromo-2-methoxyphenyl)acetic acid (16.3 g, 66.6 mmol) is dissolved in DCM (300 ml). A 1 M solution of BBr3 in DCM (200 ml, 50.1 mmol) is added dropwise at 0 C. The solution is warmed to room temperature while stirring within 90 min. Stirring at room temperature is continued for 2 h, then, it is cooled to 0 C again. Water (250 ml) is added and the solution is slowly warmed to room temperature. The precipitate is filtered off and washed with water. The layers of the filtrate are separated. The aqueous layer is extracted with DCM (2 x 100 ml). The combined organic layers are dried over Na2S04 and the solvent is removed in vacuo. The residue is combined with the solid of the filtration and dissolved in xylene (400 ml). p-Toluenesulfonic acid (160 mg) is added in catalytic amounts and the mixture is heated under reflux using a Dean-Stark trap overnight. The reaction is cooled to 100 C and filtered. The xylene filtrate is washed with water (100 ml) and brine (100 ml) and is dried over Na2S04. The solvent is removed in vacuo. The crude material BB-7 (9.7 g, 45.5 mmol, 68%) is obtained as white solid and is used in the next step without further purification. 1 H NMR (CDCb, 300 MHz), delta [ppm] = 3.75 (s, 2H, -CH2-), 7.00 (d, 1 H, H-7, 3 J = 9.4 Hz),
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