Home Cart 0 Sign in  

[ CAS No. 1694-83-3 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1694-83-3
Chemical Structure| 1694-83-3
Structure of 1694-83-3 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 1694-83-3 ]

Related Doc. of [ 1694-83-3 ]

Alternatived Products of [ 1694-83-3 ]

Product Details of [ 1694-83-3 ]

CAS No. :1694-83-3 MDL No. :MFCD03208895
Formula : C6H14N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 146.19 Pubchem ID :-
Synonyms :

Safety of [ 1694-83-3 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 1694-83-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1694-83-3 ]

[ 1694-83-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 5299-60-5 ]
  • [ 1694-83-3 ]
YieldReaction ConditionsOperation in experiment
82% With hydrazine hydrate; In methanol; water; for 5h;Cooling with ice; Reflux; General procedure: To a stirred solution of esters 2a-2j (70 mmol) in MeOH (30 mL) cooled in an ice-water bath was added dropwise 80% aqueous hydrazine hydrate (6.26 g, 100 mmol). The resulting solution was stirred at room temperature (2a-2b or 2d-2j), or reflux (2c), until the completion of reaction as indicated by TLC analysis (typically within 5 h). The reaction mixture was evaporated on a rotary evaporator to give a residue, which was purified by column chromatography through a short silica gel column to yield 3a-3k after trituration with n-hexane if possible.
  • 2
  • [ 502-44-3 ]
  • [ 1694-83-3 ]
YieldReaction ConditionsOperation in experiment
100% With hydrazine hydrate monohydrate 6 Example 6 Example 6 Synthesis of 5-(4-(2,4-dichlorophenyl)-5-(methylthio)-4H-1,2,4-triazole-3-yl)pentan-1-ol (Compound 6) ε-Caprolactone (500 mg, 4.38 mmol) was added to a 25-mL round-bottom flask, hydrazine monohydrate (329 mg, 5.26 mmol, purity: 80%) was added, 8 mL of ethanol was added, and the resulting mixture was refluxed overnight and dried via rotary evaporation to obtain 6-hydroxyhexanohydrazide as a crude product, with a yield of approximately 100%.
97% With hydrazine hydrate monohydrate In ethanol for 12h; Heating;
81% With hydrazine hydrate monohydrate In N,N-dimethyl-formamide at 20℃; for 1h;
80% With hydrazine hydrate monohydrate In ethanol for 70h; Reflux; Synthesis of ω-hydroxyalkanehydrazide 11a and 11b: 6-Hydroxyhexanehydrazide (11b):3 A solution of ε-caprolactone (5 g, 4.65 mL, 0.0438 mol) and hydrazine hydrate (80%, 8.2 g, 8 mL, 0.131 mol) in EtOH (30 mL) was refluxed for 70 h. The reaction mixture was cooled to 0 °C, and the precipitated product was filtered and washed with a small amount of Et2O. Yield: 80% yield as a white solid; mp 117-119 °C (lit.3 166.5-118 °C). 1H NMR (500 MHz, DMSO-d6) δ 8.90 (s, 1H), 4.33 (t, J = 5.1 Hz, 1H), 4.12 (s, 2H), 3.36 (td, J = 6.6, 5.1 Hz, 2H), 1.99 (t, J = 7.4 Hz, 2H), 1.50 - 1.43 (m, 2H), 1.44 - 1.33 (m, 2H), 1.29 - 1.19 (m, 2H). 13C NMR (126 MHz, DMSO-d6) δ 171.77, 60.78, 33.68, 32.44, 25.40, 25.35. Anal. Calcd for C6H14N2O2: C, 49.3; H, 9.65; N, 19.16. Found: C, 49.48; H, 9.7; N, 19.37.
64.2% With hydrazine In ethanol Reflux;
64.2% With hydrazine In ethanol for 20h; Reflux;
With hydrazine hydrate monohydrate In ethanol; benzene Heating;
With hydrazine hydrate monohydrate In ethanol 6 Example 6
Synthesis of 5-(4-(2,4-dichlorophenyl)-5-(methylthio)-4H-1,2,4-triazole-3-yl)pentan-1-ol (Compound 6)
ε-Caprolactone (500 mg, 4.38 mmol) was added to a 25-mL round-bottom flask, hydrazine monohydrate (329 mg, 5.26 mmol, purity: 80%) was added, 8 mL of ethanol was added, and the resulting mixture was refluxed overnight and dried via rotary evaporation to obtain 6-hydroxyhexanohydrazide as a crude product, with a yield of approximately 100%. The crude product (320 mg, 1.23 mmol) was weighed and charged into a new 25-mL round-bottom flask, 2,4-dichloro-1-isothiocyanatobenzene compound (324 mg, 1.58 mmol) was added, 8 mL of absolute ethanol was added, and the resulting mixture was refluxed overnight. The ethanol solution was evaporated to dryness via rotary evaporation, 8 mL of 2M aqueous sodium hydroxide solution was then added immediately, and the resulting mixture was refluxed overnight. After the complete conversion of the reaction was detected, 2M aqueous HCl solution was added slowly until the solution became acidic, and a large amount of white solid appeared. The resultant was subjected to suction filtration, washed with water and then subjected to vacuum drying, so as to obtain 5-(4-(2,4-dichlorophenyl)-5-mercapto-4H-1,2,4-triazole-3-yl)pentan-1-ol (crude product) as a white solid (315mg).

  • 3
  • [ 1892-29-1 ]
  • [ 1694-83-3 ]
  • [ 530-62-1 ]
  • [ 1243266-31-0 ]
YieldReaction ConditionsOperation in experiment
94% Stage #1: bis(2-hydroxyethyl) disulfide; 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 2h; Inert atmosphere; Stage #2: 6-hydroxyhexanoic hydrazide With pyridine; dmap In dichloromethane; N,N-dimethyl-formamide at 20℃; for 19h;
94% Stage #1: bis(2-hydroxyethyl) disulfide; 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 2h; Inert atmosphere; Stage #2: 6-hydroxyhexanoic hydrazide With pyridine; dmap In dichloromethane; N,N-dimethyl-formamide at 20℃; for 19h; Inert atmosphere;
Same Skeleton Products
Historical Records