Alternatived Products of [ 172528-62-0 ]
Product Details of [ 172528-62-0 ]
CAS No. : | 172528-62-0 |
MDL No. : | MFCD18089258 |
Formula : |
C11H13NO
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
175.23
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 172528-62-0 ]
Signal Word: | |
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Application In Synthesis of [ 172528-62-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 172528-62-0 ]
- 1
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[ 23719-80-4 ]
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[ 26830-96-6 ]
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[ 172528-62-0 ]
Yield | Reaction Conditions | Operation in experiment |
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A solution of cyclopropylmagnesium bromide (10OmL, 0.5M, 50mmol) was added drop-wise to an ice-cooled solution of 2-amino-4-methylbenzonitrile (2.36g, 17.9mmol) in Et2O (6OmL). The reaction mixture was allowed to warm slowly to ambient temperature and stirred at this temperature for 16h. The reaction mixture was cooled in ice and 2M HCl (3OmL) added drop- wise. The aqueous layer was separated and basified to pH 10 by the addition of 4M NaOH. The mixture was extracted with Et2O (2 x 10OmL) and the combined extracts dried (MgSO4). Filtration and evaporation of the solvent gave the crude product which was purified by chromatography (DCM-hexane (1:1)). 1H NMR (CDCl3) 7.86 (IH, d), 6.52 (IH, d), 6.47 (IH, s), 6.11 (2H, br s), 2.62 (IH, m), 2.28 (3H, s), 1.16 (2H, m), 0.94 (2H, m). |
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