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[ CAS No. 18739-38-3 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 18739-38-3
Chemical Structure| 18739-38-3
Structure of 18739-38-3 * Storage: {[proInfo.prStorage]}
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Product Details of [ 18739-38-3 ]

CAS No. :18739-38-3 MDL No. :MFCD19281920
Formula : C7H12ClNO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 161.63 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 18739-38-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18739-38-3 ]

[ 18739-38-3 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 683748-50-7 ]
  • [ 18739-38-3 ]
  • 4-methyl-piperidine-1-carboxylic acid 4-fluoro-1H-indazol-3-yl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
31% With pyridine for 6h; Heating / reflux;
31% With pyridine for 4h; Heating / reflux; 3 4-Fluoro-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate 100 mg (0.66 mmol) of 4-fluoro-1H-indazol-3-ol and 116.8 mg (0.72 mmol) of 4-methylpiperidine-1-carbonyl chloride (Example 2) in 10 ml of pyridine were heated under reflux for 4 h and left to stand overnight. Addition of 24 mg of 4-methyl-piperidine-1-carbonyl chloride was followed by heating under reflux for a further 2 h while the pyridine was distilled off in vacuo, and the residue was dissolved in water and extracted with ethyl acetate. The organic phase was concentrated and purified by preparative HPLC (PR18, acetonitrile/water 0.1% TFA). Yield: 56 mg (31%), M+H+: 278.1.
  • 2
  • [ 61977-29-5 ]
  • [ 18739-38-3 ]
  • 4-methyl-piperidine-1-carboxylic acid 6-chloro-benzo[d]isoxazol-3-yl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
42% With pyridine; triethylamine at 20℃; for 24h;
  • 3
  • [ 16880-54-9 ]
  • [ 18739-38-3 ]
  • 4-methyl-piperidine-1-carboxylic acid isoxazolo[5,4-b]pyridin-3-yl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
42% With pyridine; triethylamine at 20℃; for 10h;
  • 4
  • [ 60832-72-6 ]
  • [ 18739-38-3 ]
  • 3-(4-methyl-piperidine-1-carbonyl)-3H-oxazolo[4,5-b]pyridin-2-one [ No CAS ]
  • 5
  • [ 73895-37-1 ]
  • [ 18739-38-3 ]
  • [ 934706-69-1 ]
  • [ 934706-68-0 ]
YieldReaction ConditionsOperation in experiment
23%; 14% With triethylamine; In tetrahydrofuran; at 20℃; (5-chloro-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-(4-methylpiperidin-1-yl)-methanone 5-Chloro-3H-[1,2,3]triazolo[4,5-b]pyridine (100 mg, 0.65 mmol) were dissolved in 10 ml of THF. Then triethylamine (135 μl, 0.97 mmol) and 4-methylpiperidin-1-carbonyl chloride (146 mg, 0.9 mmol) were added and stirred at room temperature for 4 h and left to stand overnight. The reaction mixture was concentrated and the residue was mixed with water and ethyl acetate. The organic phase was separated off, the aqueous phase was extracted once more, and the combined organic phases were washed with water and concentrated. The crude product was purified by preparative HPLC (PR18, acetonitrile/water 0.1% TFA). Yield:
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