Home Cart 0 Sign in  

[ CAS No. 1891087-61-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1891087-61-8
Chemical Structure| 1891087-61-8
Structure of 1891087-61-8 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 1891087-61-8 ]

Related Doc. of [ 1891087-61-8 ]

Alternatived Products of [ 1891087-61-8 ]

Product Details of [ 1891087-61-8 ]

CAS No. :1891087-61-8 MDL No. :MFCD31657337
Formula : C27H24F2N6O4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 534.51 Pubchem ID :-
Synonyms :

Safety of [ 1891087-61-8 ]

Signal Word: Class:N/A
Precautionary Statements: UN#:N/A
Hazard Statements: Packing Group:N/A

Application In Synthesis of [ 1891087-61-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1891087-61-8 ]

[ 1891087-61-8 ] Synthesis Path-Downstream   1~1

YieldReaction ConditionsOperation in experiment
Stage #1: With boron tribromide In dichloromethane at 0 - 20℃; for 72h; Stage #2: With water; sodium hydroxide In dichloromethane Cooling; 2.1.3 Example 2-1-1 Preparation of 2-{4-[(3-{4-[(3-chloropyridin-4-yl)amino]-5-methoxypyrimiclin-2-yl}-1 H- indazol-1 -yl)methyl]-3,5-d General procedure: Example 2-1-1 Preparation of 2-{4-[(3-{4-[(3-chloropyridin-4-yl)amino]-5-methoxypyrimiclin-2-yl}-1 H- indazol-1 -yl)methyl]-3,5-d 177 mg of N-(3-Chloropyridin-4-yl)-2-{1 -[2,6-difluoro-4-(2-methoxyethoxy)benzyl]-1 H- indazol-3-yl}-5-methoxypyrimidin-4-amine 1-9-1 (0.32 mmol, 1.0 eq.) were dissolved in 8.2 mL dichloromethane and cooled down to 0 "C. 1 .0 mL tribromoborane (1 M in dichloromethane, 1 .0 mmol, 3.2 eq.) was slowly added at CC. When all tribromoborane was added, the icebath was removed and the mixture was stirred at rt for 72 h. The reaction mixture was diluted with icewater and DCM and 2-molar sodiumhydroxide- solution was added until pH12. The layers were seperated and the aquoeus layer was extracted with dichloromethane twice. The crude product was purified by flash chromatography to provide the 91 % pure target compounds: 26 mg, which was further purified py HPLC: 100% pure, 7.9 mg, 15 μιηοΙ, 12% 1 H-NMR (400MHz, DMSO-d6): δ [ppm]= 3.68 (q, 2H), 4.01 (t, 2H), 4.08 (s, 3H), 4.88 (t, 1 H), 5.69 (s, 2H), 6.75 - 6.90 (m, 2H), 7.27 (t, 1 H), 7.50 (t, 1 H), 7.85 (d, 1 H), 8.26 (s, 1 H), 8.40 (d, 1 H), 8.43 - 8.54 (m, 2H), 8.65 (s, 1 H), 8.98 (d, 1 H).
Same Skeleton Products
Historical Records