[ CAS No. 19551-16-7 ] {[proInfo.proName]}

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2D 3D

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Quality Control of [ 19551-16-7 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 19551-16-7 ]

Product Details of [ 19551-16-7 ]

CAS No. :	19551-16-7	MDL No. :	MFCD00277645
Formula :	C₁₀H₆Cl₂O₄S₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	325.19	Pubchem ID :	-
Synonyms :

Safety of [ 19551-16-7 ]

Signal Word:		Class:
Precautionary Statements:		UN#:
Hazard Statements:		Packing Group:

Application In Synthesis of [ 19551-16-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 19551-16-7 ]
Downstream synthetic route of [ 19551-16-7 ]

[ 19551-16-7 ] Synthesis Path-Upstream 1~1

1
[ 19551-16-7 ]
[ 71977-56-5 ]

Reference： [1] Journal of the American Chemical Society, 2011, vol. 133, # 30, p. 11426 - 11429
[2] Proceedings - Indian Academy of Sciences, Section A, 1953, vol. <A> 37, p. 114,117
[3] Journal of the American Chemical Society, 1951, vol. 73, p. 1097,1098
[4] Journal of Organic Chemistry USSR (English Translation), 1985, vol. 21, # 1, p. 145 - 148[5] Zhurnal Organicheskoi Khimii, 1985, vol. 21, # 1, p. 161 - 164

[ 19551-16-7 ] Synthesis Path-Downstream 1~2

1
[ 19551-16-7 ]
[ 40492-93-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: SOCl₂, (PhCO)2O₂ / CCl₄ 2: Cu, KOH, EtOH / 190 °C

Reference： [1]Rosowsky; Battaglia; Chen; Papathanasopoulos; Modest [Journal of the Chemical Society. Perkin transactions I, 1969, vol. 10, p. 1376 - 1378]

2
[ 116797-02-5 ]
[ 19551-16-7 ]
2,7-bis((4-methyl-[1,4'-bipiperidin]-1'-yl)sulfonyl)naphthalene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%	With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	1.II 2,7-bis((4-methyl-[1,4′-bipiperidin]-1′-yl)sulfonyl)naphthalene: A mixture of amine (1.0 mmol), sulfonyl chloride (1.1 mmol), N,N-diisopropyl ethylamine (1.5 mmol), and CH2Cl2 (5 mL) was stirred at room temperature overnight. The reaction solution was then poured into saturated NaHCO3 solution (20 ml) and extracted by CH2Cl2 (3*20 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified either through flash chromatography on silica gel with a MeOH:CH2Cl2 (or MeOH:EtOAc) mixture as eluent or by recrystallization from a mixture of CH2Cl2 and hexane to provide the sulfonamides.This compound was obtained as a white solid (92%) through flash chromatography (1:19 MeOH:CH2Cl2) after the reaction of 4-methyl-1,4′-bipiperidine (0.39 mmol) with naphthalene-2,7-disulfonyl dichloride (0.15 mmol) in CH2C12 (2.5 mL) in the presence of N, N-diisopropyl ethylamine (0.52 mmol). mp 265-268° C.; NMR (400 MHz, CDCl3) δ 8.42 (s, 2H), 8.04 (d, J=8.7 Hz, 2H), 7.89 (dd, J=8.6, 1.7 Hz, 2H), 3.92 (d, J=12.3 Hz, 4H), 2.75 (d, J=11.7 Hz, 4H), 2.32 (td, J=12.1, 2.4 Hz, 4H), 2.25-1.99 (m, 6H), 1.84 (d, J=11.5 Hz, 4H), 1.72-1.51 (m, 8H), 1.37-1.21 (m, 2H), 1.21-1.07 (m, 4H), 0.86 (d, J=6.3 Hz, 6H); 13C NMR (100 MHz, CDCl3) δ 136.0, 135.5, 131.3, 129.7, 129.2, 125.8, 61.4, 49.5, 46.2, 34.5, 31.0, 27.4, 21.8; MS (ESI) m/z 617.3 (100%, [M+H]+)

Reference： [1]Current Patent Assignee: THE UNIVERSITY OF TEXAS SYSTEM - US2015/232444, 2015, A1 Location in patent: Paragraph 0304; 0342

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
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Prevention
Code	Phrase
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P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
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P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
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P370 + P378	In case of fire:
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P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P401
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Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
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H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
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H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
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Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
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H310	Fatal in contact with skin
H311	Toxic in contact with skin
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H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 19551-16-7 ] {[proInfo.proName]}

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[ 19551-16-7 ] Synthesis Path-Upstream 1~1

[ 19551-16-7 ] Synthesis Path-Downstream 1~2

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