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[ CAS No. 20846-52-0 ] {[proInfo.proName]}

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Chemical Structure| 20846-52-0
Chemical Structure| 20846-52-0
Structure of 20846-52-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 20846-52-0 ]

CAS No. :20846-52-0 MDL No. :MFCD00129739
Formula : C2H5ClN2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 92.53 Pubchem ID :-
Synonyms :

Safety of [ 20846-52-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 20846-52-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 20846-52-0 ]
  • Downstream synthetic route of [ 20846-52-0 ]

[ 20846-52-0 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 594-42-3 ]
  • [ 20846-52-0 ]
  • [ 21734-85-0 ]
  • [ 74461-64-6 ]
Reference: [1] Patent: US4242350, 1980, A,
  • 2
  • [ 333-20-0 ]
  • [ 20846-52-0 ]
  • [ 17467-35-5 ]
YieldReaction ConditionsOperation in experiment
32% at 0 - 20℃; for 12 h; Compound LXII (5.1 g, 55 mmol) was dissolved in methanol (250 mL) and the resulting solution was cooled to 0° C. Potassium thiocyanate (5.3 g, 55 mmol) was then added. The resulting solution was stirred for 12 hours at room temperature, concentrated under reduced pressure, diluted with ethyl acetate (200 mL), and filtered under reduced pressure to remove a solid. The filtrate was concentrated under reduced pressure, creating a solid which was filtered under reduced pressure to yield Compound LXIII (2 g (32percent)). The filtrate was further concentrated and applied to column chromatography (SiO2, n-hex:EA=4:1) to yield Compound LXIII (2 g (32percent)).1H NMR (600 MHz, CD3OD) δ 3.27 (s, 3H)
32% at 0 - 20℃; for 12 h; Compound LXII (5,1 g, 55 mmol) was dissolved in methanol (250 mL) and the resulting solution was cooled to 0 . Potassium thiocyanate (5.3 g, 55 mmol) was then added. The resulting solution was stirred for 12 hours at room temperature, concentrated under reduced pressure, diluted with ethyl acetate (200 mL), and filtered under reduced pressure to remove a solid. The filtrate was concentrated under reduced pressure, creating a solid which was filtered under reduced pressure to yield Compound LXIII (2 g (32percent)). The filtrate was further concentrated and applied to column chromatography (SiO2, n-hex : EA = 4 : 1) to yield Compound LXIII (2 g (32percent)). 1H NMR (600MHz, CD3OD) δ 3.27(s, 3H)
Reference: [1] Patent: US2012/264727, 2012, A1, . Location in patent: Page/Page column 53
[2] Patent: EP2706062, 2014, A2, . Location in patent: Paragraph 0199
  • 3
  • [ 102-52-3 ]
  • [ 20846-52-0 ]
  • [ 54198-88-8 ]
Reference: [1] Organic Letters, 2011, vol. 13, # 6, p. 1436 - 1439
[2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 2, p. 363 - 386
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