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[ CAS No. 209909-13-7 ] {[proInfo.proName]}

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Chemical Structure| 209909-13-7
Chemical Structure| 209909-13-7
Structure of 209909-13-7 * Storage: {[proInfo.prStorage]}
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CAS No. :209909-13-7 MDL No. :MFCD06239276
Formula : C10H4ClF2NO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 227.60 Pubchem ID :-
Synonyms :

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 209909-13-7 ]

[ 209909-13-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 458-11-7 ]
  • [ 33513-42-7 ]
  • [ 209909-13-7 ]
YieldReaction ConditionsOperation in experiment
Example C: Preparation of {2-[N-(cyclopentylmethyl)-N-ethylamino]-6,7-difluoroquinolin-3- yljmethanolStep 1 : <n="81"/>Phosphoryl chloride (147.1 mL) is carefully added to DMF (32.5 ml.) at 0-15 0C to prepare a solution of vilsmeier reagent in phosphoryl chloride, and the mixture is warmed to 30 0C to give clear pale yellow mixture. <strong>[458-11-7]3,4-difluoroacetanilide</strong> (30 g, 0.12 mol) is added to the mixture, and the resulting mixture is stirred at 80 0C for 30 min, 90 0C for 30 min, 100 0C for 18 hours, and finally 120 0C for 2 hours. The mixture is cooled to room temperature, poured onto ice-water (1500 mL) and extracted with CH2CI2 7 times (total 3000 mL). The combined organic layer is dried over magnesium sulfate, filtered and concentrated. The brown crystal is collected and washed with CH2CI2 to give 2-chloro-6,7-difluoroquinoline-3-carbaldehyde as a pale yellow powder. 1H-NMR (400MHz, CDCI3), δ (ppm): 7.73 (dd, 1 H), 7.84 (dd, 1 H), 8.69 (s, 1 H), 10.55 (s, 1 H).
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