Alternatived Products of [ 234107-95-0 ]
Product Details of [ 234107-95-0 ]
CAS No. : | 234107-95-0 |
MDL No. : | MFCD12024301 |
Formula : |
C7H8INO
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
249.05
|
Pubchem ID : | - |
Synonyms : |
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Safety of [ 234107-95-0 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 234107-95-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 234107-95-0 ]
- 1
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[ 65550-78-9 ]
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[ 234107-95-0 ]
Yield | Reaction Conditions | Operation in experiment |
71% |
With sodium methylate; In methanol; dimethyl sulfoxide; at 0 - 70℃; |
A. 5-Iodo-3-methyl-2-methoxy-pyridine. To a solution containing <strong>[65550-78-9]2-bromo-5-iodo-3-methyl-pyridine</strong> (4.80 g, 16.0 mmol) in DMSO (15 ML) is added methanolic NaOMe (3.33 M, 5.3 ML, 17.7 mmol) at 0 C. The solution is allowed to warm to ambient temperature and then heated at 70 C. for 1 hour.The reaction mixture is diluted with diethyl ether (300 ML) and water (200 ML) and the layers are separated.The organic phase is washed with brine, dried over anhydrous Na2SO4, filtered and concentrated.The crude product is purified by silica gel flash column chromatography (hexane/diethyl ether, 19:1) to provide 2.86 g (71%) of the title compound as a white solid. 1H NMR (300 MHz, CDCl3) delta2.12 (s, 3H), 3.90 (s, 3H), 7.60 (d, J=2.1 Hz, 1H), 8.14 (d, J=2.1 Hz, 1H) ppm; MS (EI): m/z 249 (M+). |