[ CAS No. 2437-42-5 ] {[proInfo.proName]}

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Quality Control of [ 2437-42-5 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 2437-42-5 ]

SDS Specification

Alternatived Products of [ 2437-42-5 ]

Product Details of [ 2437-42-5 ]

CAS No. :	2437-42-5	MDL No. :	MFCD02665277
Formula :	C₁₁H₁₁N	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	157.21	Pubchem ID :	-
Synonyms :

Safety of [ 2437-42-5 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 2437-42-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 2437-42-5 ]

[ 2437-42-5 ] Synthesis Path-Downstream 1~33

1
[ 110-00-9 ]
[ 95-53-4 ]
[ 2437-42-5 ]

Reference： [1]Chemische Berichte,1936,vol. 69,p. 1944
Zhurnal Obshchei Khimii,1937,vol. 7,p. 267
Chemisches Zentralblatt,1937,vol. 108,p. 3952

2
[ 696-59-3 ]
[ 95-53-4 ]
[ 2437-42-5 ]

Yield	Reaction Conditions	Operation in experiment
90%	With L-(+)-tartaric acid-choline chloride based deep eutectic solvent; at 90℃; for 0.666667h;Green chemistry;	General procedure: Amine (1 mmol), 2,5-dimethoxytetrahydrofuran (1.1 mmol)and L-(+)-tartaric acid-choline chloride based DES (1.5 g) were added to a 50 mL round bottom flask and the reaction mixturewas stirred at 90 C. The progress of the reaction was monitoredby TLC. After completion of the reaction, the mixture was cooled to room temperature and the product was extracted with ethyl acetate.After the evaporation of the solvent, the residue was purified by columnchromatography on silica gel to afford the pure product. The DES wasdried under vacuumand reused for the next cycle.
89%	With ionic liquid immobilized on gamma-Fe2O3(at)SiO2 nanoparticles; In water; at 100℃; for 0.666667h;	General procedure: To a solution of amine (1 mmol) in water (2 ml) was added tetrahydro-2,5-dimethoxyfuran (1.1 mmol) and gamma-Fe2O3(at)SiO2-Sb-IL (0.08 g). The reaction mixture was stirred at 100 C for a certain period of time as required to complete the reaction. During that time, the reaction was monitored constantly by TLC. After completion of the reaction, the catalyst was removed by using a magnet and washed with ethyl acetate. The aqueous solution was extracted by ethyl acetate (3 × 5 ml). The combined organic phase was dehydrated with anhydrous sodium sulfate. After the evaporation of the solvent, the residue was purified by silica gel flash chromatography using petroleum ether/ethyl acetate as the eluent to afford the pure product.
84%	With magnesium iodide etherate; In acetonitrile; at 80℃; for 6h;	General procedure: A Schlenk reaction tube was charged with primary aromatic amine (5.0 mmol), 2,5-dimethoxytetrahydrofuran (6.0 mmol), MgI2 etherate (10% mmol), and acetonitrile (10 mL). The reaction mixture was stirred at 80 C for several hours and then concentrated in vacuo. The residue was purified by flash column chromatography on a silica gel to give the desired product.

Reference： [1]Tetrahedron Letters,2009,vol. 50,p. 4807 - 4809
[2]Synlett,2009,p. 2245 - 2248
[3]Monatshefte fur Chemie,2013,vol. 144,p. 405 - 409
[4]Journal of Molecular Liquids,2014,vol. 198,p. 259 - 262
[5]Applied Catalysis A: General,2013,vol. 457,p. 34 - 41
[6]Journal of Chemical Research,2009,p. 14 - 16
[7]Tetrahedron,2011,vol. 67,p. 898 - 903
[8]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 3753 - 3757
[9]Journal of Heterocyclic Chemistry,2019,vol. 56,p. 1337 - 1340
[10]Journal of Medicinal Chemistry,2014,vol. 57,p. 6531 - 6552
[11]Acta Chemica Scandinavica (1947),1952,vol. 6,p. 867,872

3
[ 2437-42-5 ]
[ 42824-16-8 ]
1-o-tolyl-pyrrole-2-sulfonic acid [ No CAS ]

Reference： [1]Zhurnal Obshchei Khimii,1949,vol. 19,p. 538,540; engl. Ausg. S. 487, 489

4
[ 2437-42-5 ]
[ 42824-16-8 ]
[ 107-06-2 ]
1-o-tolyl-pyrrole-2-sulfonic acid [ No CAS ]

Reference： [1]Zhurnal Obshchei Khimii,1949,vol. 19,p. 538,540; engl. Ausg. S. 487, 489

5
[ 2437-42-5 ]
[ 368212-31-1 ]

Reference： [1]Chemische Berichte,1904,vol. 37,p. 2794

6
[ 2437-42-5 ]
[ 762-42-5 ]
[ 635-10-9 ]

Reference： [1]Journal of Organic Chemistry,1980,vol. 45,p. 4573 - 4582

7
[ 2437-42-5 ]
[ 762-42-5 ]
[ 74986-15-5 ]
[ 74986-03-1 ]
[ 74965-14-3 ]

Reference： [1]Journal of Organic Chemistry,1980,vol. 45,p. 4573 - 4582

8
[ 696-59-3 ]
[ 95-53-4 ]
[ 2437-42-5 ]
[ 41378-30-7 ]

Reference： [1]Synthesis,1999,p. 74 - 79
[2]Synthesis,1999,p. 74 - 79

10
mucate o-toluidine [ No CAS ]
[ 2437-42-5 ]

Reference： [1]Chemische Berichte,1904,vol. 37,p. 2794

11
[ 2437-42-5 ]
[ 124-38-9 ]
[ 55540-39-1 ]
[ 35524-49-3 ]

Reference： [1]Journal of Chemical Research - Part S,2003,p. 132 - 133
[2]Journal of Chemical Research - Part S,2003,p. 132 - 133

12
[ 2437-42-5 ]
[ 124-38-9 ]
[ 35524-49-3 ]
1-(2-carboxymethyl-phenyl)-1H-pyrrole-2-carboxylic acid [ No CAS ]

Reference： [1]Journal of Chemical Research - Part S,2003,p. 132 - 133

13
[ 109-97-7 ]
[ 615-37-2 ]
[ 2437-42-5 ]

Yield	Reaction Conditions	Operation in experiment
37%	With copper(ll) sulfate pentahydrate; sodium hydroxide; In dimethyl sulfoxide; at 110℃; for 12h;Sealed tube;	General procedure: CuSO4·5H2O (12.50 mg, 0.05 mmol), the aryl iodide or bromide(1.0 mmol), pyrrole (1.5 mmol), NaOH (80 mg, 2 mmol), and DMSO(2 mL) were placed in a 10 mL sealed tube. The mixture was heatedat 110 C in a preheated oil bath for 12 h. It was then cooled to roomtemperature, diluted with 20 mL H2O, and the mixture was extractedwith ethyl acetate (3 × 20 mL). The combined organic phases waswashed with water and brine, dried over anhydrous Na2SO4, andconcentrated in vacuo. The residue was purified by flash columnchromatography on silica gel (ethyl acetate/petroleum ether, 1 : 100)to afford the target products. All C-N coupling products reported hereare known products and were characterised by GC-MS and 1H NMR,which were compared with the previously reported dates.

Reference： [1]Tetrahedron Letters,2007,vol. 48,p. 245 - 248
[2]Journal of Chemical Research,2014,vol. 38,p. 180 - 182
[3]Organic Letters,2004,vol. 6,p. 2405 - 2408

14
[ 2437-42-5 ]
[ 55962-05-5 ]
3,4-di(toluene-p-sulfonamido)-1-(2-methylphenyl)pyrrole [ No CAS ]

Reference： [1]Organic Letters,2004,vol. 6,p. 2405 - 2408

15
[ 2437-42-5 ]
[ 68-12-2 ]
[ 35524-41-5 ]
[ 864547-96-6 ]

Reference： [1]Synthesis,2012,vol. 44,p. 1353 - 1358
[2]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 3753 - 3757

16
[ 109-97-7 ]
[ 95-46-5 ]
[ 2437-42-5 ]

Reference： [1]Journal of Organic Chemistry,2004,vol. 69,p. 5578 - 5587

17
[ 2437-42-5 ]
[ 143-33-9 ]
[ 35524-47-1 ]

Reference： [1]Journal of Heterocyclic Chemistry,2006,vol. 43,p. 681 - 684

18
[ 109-97-7 ]
[ 95-53-4 ]
[ 2437-42-5 ]

Reference： [1]Synlett,2006,p. 1428 - 1430

19
[ 2437-42-5 ]
1-(2-methoxy-phenyl)-4-(1-o-tolyl-1H-pyrrol-3-ylmethyl)-piperazine [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 3753 - 3757

20
[ 2437-42-5 ]
1-(2-methoxy-phenyl)-4-(1-o-tolyl-1H-pyrrol-2-ylmethyl)-piperazine [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 3753 - 3757

21
[ 2437-42-5 ]
3-[4-(1-o-tolyl-1H-pyrrol-2-ylmethyl)-piperazin-1-yl]-benzo[d]isoxazole [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 3753 - 3757

22
[ 2437-42-5 ]
3-[4-(1-o-tolyl-1H-pyrrol-3-ylmethyl)-piperazin-1-yl]-benzo[d]isoxazole [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 3753 - 3757

23
[ 696-59-3 ]
[ 24544-04-5 ]
[ 95-53-4 ]
[ 2437-42-5 ]
1-(2,6-diisopropylphenyl)-1H-pyrrole [ No CAS ]