Alternatived Products of [ 244240-24-2 ]
Product Details of [ 244240-24-2 ]
CAS No. : | 244240-24-2 |
MDL No. : | MFCD09878279 |
Formula : |
C11H8Br2N2O2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | UVSVTDVJQAJIFG-VURMDHGXSA-N |
M.W : |
360.00
|
Pubchem ID : | 54676905 |
Synonyms : |
LFM-A13
|
Safety of [ 244240-24-2 ]
Signal Word: | Warning |
Class: | N/A |
Precautionary Statements: | P280 |
UN#: | N/A |
Hazard Statements: | H302-H312-H332 |
Packing Group: | N/A |
GHS Pictogram: |
|
Application In Synthesis of [ 244240-24-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 244240-24-2 ]
- 1
-
[ 63034-99-1 ]
-
[ 75-36-5 ]
-
[ 244240-24-2 ]
Yield | Reaction Conditions | Operation in experiment |
78% |
Stage #1: N-(2,5-dibromophenyl)-2-cyanoacetamide With sodium hydride In tetrahydrofuran at -0.15℃; for 1h;
Stage #2: acetyl chloride In tetrahydrofuran for 1h; room t.; |
|
35.3% |
With potassium <i>tert</i>-butylate In tetrahydrofuran at 20℃; |
|
|
Stage #1: N-(2,5-dibromophenyl)-2-cyanoacetamide With sodium hydride In tetrahydrofuran at 20℃;
Stage #2: acetyl chloride In tetrahydrofuran at 20℃; |
|
Reference:
[1]Ghosh, Sutapa; Uckun, Fatih M.
[Acta Crystallographica, Section C: Crystal Structure Communications, 1999, vol. 55, # 8, p. 1364 - 1365]
[2]Tibbles, Heather E.; Samuel, Peter; Erbeck, Doug; Mahajan, Sandeep; Uckun, Fatih M.
[Arzneimittel-Forschung/Drug Research, 2004, vol. 54, # 6, p. 330 - 339]
[3]Venkatachalam; Zheng; Ghosh; Uckun
[Journal of Molecular Structure, 2005, vol. 743, # 1-3, p. 103 - 115]
- 2
-
[ 63034-99-1 ]
-
[ 108-24-7 ]
-
[ 244240-24-2 ]
Yield | Reaction Conditions | Operation in experiment |
79% |
With sodium t-butanolate In tetrahydrofuran at 20℃; |
|
- 3
-
[ 3638-73-1 ]
-
[ 244240-24-2 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 93 percent / 1,3-diisopropylcarbodiimide / ethyl acetate / 24 h / 20 °C
2: 79 percent / sodium tert-butoxide / tetrahydrofuran / 20 °C |
|
|
Multi-step reaction with 2 steps
1.1: DIC / tetrahydrofuran / 20 °C
2.1: NaH / tetrahydrofuran / 20 °C
2.2: tetrahydrofuran / 20 °C |
|
|
Multi-step reaction with 2 steps
1: 92.5 percent / 1,3-diisopropylcarbodiimide (DIC) / tetrahydrofuran / 20 °C
2: 35.3 percent / potassium tert-butoxide / tetrahydrofuran / 20 °C |
|
|
Multi-step reaction with 2 steps
1.1: 95 percent / i-Pr2-CDI / tetrahydrofuran / room t., overnight
2.1: NaH / tetrahydrofuran / 1 h / -0.15 °C
2.2: 78 percent / tetrahydrofuran / 1 h / room t. |
|
Reference:
[1]DuMez, Darin; Venkatachalam, Taracad K.; Uckun, Fatih M.
[Arzneimittel-Forschung/Drug Research, 2007, vol. 57, # 3, p. 155 - 163]
[2]Venkatachalam; Zheng; Ghosh; Uckun
[Journal of Molecular Structure, 2005, vol. 743, # 1-3, p. 103 - 115]
[3]Tibbles, Heather E.; Samuel, Peter; Erbeck, Doug; Mahajan, Sandeep; Uckun, Fatih M.
[Arzneimittel-Forschung/Drug Research, 2004, vol. 54, # 6, p. 330 - 339]
[4]Ghosh, Sutapa; Uckun, Fatih M.
[Acta Crystallographica, Section C: Crystal Structure Communications, 1999, vol. 55, # 8, p. 1364 - 1365]