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[ CAS No. 250249-85-5 ]

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Inaccessible (Haz class 6.1), Domestic USD 41.00
Inaccessible (Haz class 6.1), International USD 64.00
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 83.00
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Chemical Structure| 250249-85-5
Chemical Structure| 250249-85-5
Structure of 250249-85-5 * Storage: {[proInfo.prStorage]}

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Product Details of [ 250249-85-5 ]

CAS No. :250249-85-5 MDL No. :MFCD02683201
Formula : C12H23NO3 Boiling Point : 324.1°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :229.32 g/mol Pubchem ID :1514244
Synonyms :

Safety of [ 250249-85-5 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P264-P270-P273-P301+P310+P330-P305+P351+P338-P337+P313-P391-P405-P501 UN#:2810
Hazard Statements:H301-H320-H400 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 250249-85-5 ]

  • Upstream synthesis route of [ 250249-85-5 ]
  • Downstream synthetic route of [ 250249-85-5 ]

[ 250249-85-5 ] Synthesis Path-Upstream   1~26

  • 1
  • [ 351410-32-7 ]
  • [ 250249-85-5 ]
YieldReaction ConditionsOperation in experiment
93% With lithium aluminium tetrahydride In tetrahydrofuran; dichloromethane at 55℃; for 4 h; Inert atmosphere General procedure: To a mixture of 2-((2S)-1-tert-butoxycarbonylpyrrolidin-2-yl)acetic acid (2.0g, 8.7mmol) in anhydrous CH2Cl2 (20mL) lithium aluminum hydride 2.0M in THF (7.23mL, 13.05mmol) was added dropwise and the reaction mixture was heated to 55°C in inert atmosphere (under argon). After stirring for 4h, the reaction mixture was cooled to room temperature, diluted with AcOEt (20mL) and treated with saturated NaHCO3 (3mL). Then the solution was concentrated under reduce pressure. To the residue were added CH2Cl2 (20mL) and the organic layer was washed with water and brine, and then dried over anhydrous Na2SO4, and concentrated under reduced pressure to give intermediate 6 (1.72g, 8.0mmol) as light oil (yield 91.9percent). The same procedure was used for the synthesis of intermediates 7–10.
Reference: [1] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 790 - 804
  • 2
  • [ 639458-48-3 ]
  • [ 250249-85-5 ]
Reference: [1] Journal of Organic Chemistry, 2003, vol. 68, # 24, p. 9525 - 9527
[2] Tetrahedron Asymmetry, 2004, vol. 15, # 18, p. 2921 - 2925
  • 3
  • [ 24424-99-5 ]
  • [ 1393603-28-5 ]
  • [ 250249-85-5 ]
Reference: [1] Organic and Biomolecular Chemistry, 2012, vol. 10, # 32, p. 6473 - 6479
  • 4
  • [ 1000806-51-8 ]
  • [ 199942-74-0 ]
  • [ 250249-85-5 ]
Reference: [1] Organic Letters, 2007, vol. 9, # 25, p. 5283 - 5286
  • 5
  • [ 813433-73-7 ]
  • [ 250249-85-5 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 17, p. 2621 - 2624
  • 6
  • [ 108-55-4 ]
  • [ 250249-85-5 ]
Reference: [1] Organic letters, 2001, vol. 3, # 2, p. 193 - 196
  • 7
  • [ 327158-12-3 ]
  • [ 250249-85-5 ]
Reference: [1] Organic letters, 2001, vol. 3, # 2, p. 193 - 196
  • 8
  • [ 327158-11-2 ]
  • [ 250249-85-5 ]
Reference: [1] Organic letters, 2001, vol. 3, # 2, p. 193 - 196
  • 9
  • [ 327158-15-6 ]
  • [ 250249-85-5 ]
Reference: [1] Organic letters, 2001, vol. 3, # 2, p. 193 - 196
  • 10
  • [ 327158-13-4 ]
  • [ 250249-85-5 ]
Reference: [1] Organic letters, 2001, vol. 3, # 2, p. 193 - 196
  • 11
  • [ 24424-99-5 ]
  • [ 68419-38-5 ]
  • [ 250249-85-5 ]
Reference: [1] Organic letters, 2001, vol. 3, # 2, p. 193 - 196
  • 12
  • [ 893442-85-8 ]
  • [ 250249-85-5 ]
Reference: [1] Bioscience, Biotechnology and Biochemistry, 2005, vol. 69, # 8, p. 1589 - 1594
  • 13
  • [ 893430-03-0 ]
  • [ 250249-85-5 ]
Reference: [1] Bioscience, Biotechnology and Biochemistry, 2005, vol. 69, # 8, p. 1589 - 1594
  • 14
  • [ 893430-06-3 ]
  • [ 250249-85-5 ]
Reference: [1] Bioscience, Biotechnology and Biochemistry, 2005, vol. 69, # 8, p. 1589 - 1594
  • 15
  • [ 893430-01-8 ]
  • [ 250249-85-5 ]
Reference: [1] Bioscience, Biotechnology and Biochemistry, 2005, vol. 69, # 8, p. 1589 - 1594
  • 16
  • [ 893430-02-9 ]
  • [ 250249-85-5 ]
Reference: [1] Bioscience, Biotechnology and Biochemistry, 2005, vol. 69, # 8, p. 1589 - 1594
  • 17
  • [ 475995-17-6 ]
  • [ 250249-85-5 ]
Reference: [1] Bioscience, Biotechnology and Biochemistry, 2005, vol. 69, # 8, p. 1589 - 1594
  • 18
  • [ 118811-03-3 ]
  • [ 250249-85-5 ]
Reference: [1] Journal of Organic Chemistry, 2003, vol. 68, # 24, p. 9525 - 9527
  • 19
  • [ 1484-84-0 ]
  • [ 250249-85-5 ]
Reference: [1] Organic and Biomolecular Chemistry, 2012, vol. 10, # 32, p. 6473 - 6479
  • 20
  • [ 28697-17-8 ]
  • [ 250249-85-5 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 17, p. 2621 - 2624
  • 21
  • [ 893430-07-4 ]
  • [ 250249-85-5 ]
Reference: [1] Bioscience, Biotechnology and Biochemistry, 2005, vol. 69, # 8, p. 1589 - 1594
  • 22
  • [ 893430-09-6 ]
  • [ 250249-85-5 ]
Reference: [1] Bioscience, Biotechnology and Biochemistry, 2005, vol. 69, # 8, p. 1589 - 1594
  • 23
  • [ 1000806-51-8 ]
  • [ 250249-85-5 ]
Reference: [1] Tetrahedron, 2011, vol. 67, # 38, p. 7412 - 7417
  • 24
  • [ 639458-46-1 ]
  • [ 250249-85-5 ]
Reference: [1] Tetrahedron, 2011, vol. 67, # 38, p. 7412 - 7417
  • 25
  • [ 108-05-4 ]
  • [ 118811-03-3 ]
  • [ 199942-74-0 ]
  • [ 250249-85-5 ]
  • [ 639458-49-4 ]
  • [ 639458-48-3 ]
Reference: [1] Journal of Organic Chemistry, 2003, vol. 68, # 24, p. 9525 - 9527
  • 26
  • [ 250249-85-5 ]
  • [ 787622-24-6 ]
Reference: [1] Patent: EP3418276, 2018, A1,
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