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[ CAS No. 25370-09-6 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
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Chemical Structure| 25370-09-6
Chemical Structure| 25370-09-6
Structure of 25370-09-6 * Storage: {[proInfo.prStorage]}
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Product Details of [ 25370-09-6 ]

CAS No. :25370-09-6 MDL No. :MFCD02181136
Formula : C15H14ClNO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 259.73 Pubchem ID :-
Synonyms :

Safety of [ 25370-09-6 ]

Signal Word:Danger Class:8
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501 UN#:3261
Hazard Statements:H302-H314 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 25370-09-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 25370-09-6 ]

[ 25370-09-6 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 25370-09-6 ]
  • [ 129722-12-9 ]
  • [ 1352726-36-3 ]
YieldReaction ConditionsOperation in experiment
With silver (II) carbonate In 2-methyltetrahydrofuran for 96h; Reflux; 5 A mixture of aripiprazole (1.5 g, 3.3 mmol), dibenzylcarbamoyl chloride (1.74 g, 6.7 mmol) silver carbonate (3.75 g, 13.4 mmol) and 2-methyltetrahydrofuran (30 mL) was heated at reflux for 4 days. The reaction mixture was cooled, diluted with ethyl acetate and water, and then filtered through celite. The organic phase was separated, dried over MgSO4 and evaporated. The residue obtained was further purified on silica eluting with ethyl acetate/tetrahydrofuran to give after evaporation of the major product containing fractions, Compound 80 (1.02 g) was a yellow oil.1H-NMR (300 MHz, CDCl3) δ 7.44-7.21 (m, 8H), 7.20-7.10 (m, 4H), 7.04 (d, 1H), 7.00-6.93 (m, 1H), 6.57 (dd, 1H), 6.40 (d, 1H), 4.80 (d, 1H), 4.54 (d, 1H), 4.35 (d, 1H), 4.26 (d, 1H), 3.90-3.81 (m, 1H), 3.74-3.67 (m, 1H), 3.15-3.03 (m, 4H), 2.92-2.80 (m, 2H), 2.75-2.60 (m, 6H), 2.65 (t, 2H), 2.84-2.63 (m, 4H). [M+H]+=671.3.
  • 2
  • [ 25370-09-6 ]
  • [ 129722-25-4 ]
  • [ 1352726-47-6 ]
YieldReaction ConditionsOperation in experiment
With pyridine; for 4h;Reflux; To a solution of dibenzylcarbamoyl chloride (1.7 g, 6.7 mmol) in pyridine (15 mL) was added <strong>[129722-25-4]dehydro-aripiprazole</strong> (1.5 g, 3.4 mmol) and the reaction mixture heated at reflux for 4 h. The reaction mixture was concentrated and the residue co-evaporated with toluene (×3). The residue was dissolved in ethyl acetate (ethyl acetate), washed with water and dried over MgSO4. After evaporation the residue was further purified on silica eluting with ethyl acetate and after drying gave Compound 342 (0.71 g) as a white solid.1H-NMR (300 MHz, CDCl3) delta 8.13 (d, 1H), 7.70 (d, 1H), 7.42-7.29 (m, 11H), 7.20-7.08 (m, 4H), 7.00-6.92 (m, 1H), 4.64 (s, 2H), 4.56 (s, 2H), 4.14 (t, 2H), 3.15-3.02 (m, 4H), 2.74-2.60 (m, 4H), 2.58-2.48 (m, 2H), 1.98-1.88 (m, 2H), 1.83-1.70 (m, 2H). [M+H]+=669.1.
  • 3
  • [ 25370-09-6 ]
  • [ 2301-40-8 ]
  • 4
  • [ 72-18-4 ]
  • [ 25370-09-6 ]
  • (S)-2-(3,3-dibenzylureido)-3-methylbutanoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; water at 50℃; Procedure A General procedure: Procedure A: To the amino acid (1.0 mmol) in THF (2.7 mL) andwater (0.9 mL) was added N,N-diisopropylethylamine (3.0 mmol)and the carbamoyl chloride (1.1 mmol). The resulting mixture washeated to reux until judged complete by TLC or HPLC, cooled to rtand concentrated under reduced pressure. Conc. HCl (4.0 mmol)was added to neutralize base and the mixture was extracted withEtOAc. The combined organics were dried (MgSO4), ltered, andconcentrated to give the crude product as a solid mass. The materialwas puried by recrystallization from EtOAc/hexanes to give nalproduct as a crystalline solid.
  • 5
  • [ 107-97-1 ]
  • [ 25370-09-6 ]
  • 2-(3,3-dibenzyl-1-methylureido)acetic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; water at 50℃; Procedure A General procedure: Procedure A: To the amino acid (1.0 mmol) in THF (2.7 mL) andwater (0.9 mL) was added N,N-diisopropylethylamine (3.0 mmol)and the carbamoyl chloride (1.1 mmol). The resulting mixture washeated to reux until judged complete by TLC or HPLC, cooled to rtand concentrated under reduced pressure. Conc. HCl (4.0 mmol)was added to neutralize base and the mixture was extracted withEtOAc. The combined organics were dried (MgSO4), ltered, andconcentrated to give the crude product as a solid mass. The materialwas puried by recrystallization from EtOAc/hexanes to give nalproduct as a crystalline solid.
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