There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 25370-09-6 | MDL No. : | MFCD02181136 |
Formula : | C15H14ClNO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 259.73 | Pubchem ID : | - |
Synonyms : |
|
Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501 | UN#: | 3261 |
Hazard Statements: | H302-H314 | Packing Group: | Ⅱ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With silver (II) carbonate In 2-methyltetrahydrofuran for 96h; Reflux; | 5 A mixture of aripiprazole (1.5 g, 3.3 mmol), dibenzylcarbamoyl chloride (1.74 g, 6.7 mmol) silver carbonate (3.75 g, 13.4 mmol) and 2-methyltetrahydrofuran (30 mL) was heated at reflux for 4 days. The reaction mixture was cooled, diluted with ethyl acetate and water, and then filtered through celite. The organic phase was separated, dried over MgSO4 and evaporated. The residue obtained was further purified on silica eluting with ethyl acetate/tetrahydrofuran to give after evaporation of the major product containing fractions, Compound 80 (1.02 g) was a yellow oil.1H-NMR (300 MHz, CDCl3) δ 7.44-7.21 (m, 8H), 7.20-7.10 (m, 4H), 7.04 (d, 1H), 7.00-6.93 (m, 1H), 6.57 (dd, 1H), 6.40 (d, 1H), 4.80 (d, 1H), 4.54 (d, 1H), 4.35 (d, 1H), 4.26 (d, 1H), 3.90-3.81 (m, 1H), 3.74-3.67 (m, 1H), 3.15-3.03 (m, 4H), 2.92-2.80 (m, 2H), 2.75-2.60 (m, 6H), 2.65 (t, 2H), 2.84-2.63 (m, 4H). [M+H]+=671.3. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With pyridine; for 4h;Reflux; | To a solution of dibenzylcarbamoyl chloride (1.7 g, 6.7 mmol) in pyridine (15 mL) was added <strong>[129722-25-4]dehydro-aripiprazole</strong> (1.5 g, 3.4 mmol) and the reaction mixture heated at reflux for 4 h. The reaction mixture was concentrated and the residue co-evaporated with toluene (×3). The residue was dissolved in ethyl acetate (ethyl acetate), washed with water and dried over MgSO4. After evaporation the residue was further purified on silica eluting with ethyl acetate and after drying gave Compound 342 (0.71 g) as a white solid.1H-NMR (300 MHz, CDCl3) delta 8.13 (d, 1H), 7.70 (d, 1H), 7.42-7.29 (m, 11H), 7.20-7.08 (m, 4H), 7.00-6.92 (m, 1H), 4.64 (s, 2H), 4.56 (s, 2H), 4.14 (t, 2H), 3.15-3.02 (m, 4H), 2.74-2.60 (m, 4H), 2.58-2.48 (m, 2H), 1.98-1.88 (m, 2H), 1.83-1.70 (m, 2H). [M+H]+=669.1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; water at 50℃; | Procedure A General procedure: Procedure A: To the amino acid (1.0 mmol) in THF (2.7 mL) andwater (0.9 mL) was added N,N-diisopropylethylamine (3.0 mmol)and the carbamoyl chloride (1.1 mmol). The resulting mixture washeated to reux until judged complete by TLC or HPLC, cooled to rtand concentrated under reduced pressure. Conc. HCl (4.0 mmol)was added to neutralize base and the mixture was extracted withEtOAc. The combined organics were dried (MgSO4), ltered, andconcentrated to give the crude product as a solid mass. The materialwas puried by recrystallization from EtOAc/hexanes to give nalproduct as a crystalline solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; water at 50℃; | Procedure A General procedure: Procedure A: To the amino acid (1.0 mmol) in THF (2.7 mL) andwater (0.9 mL) was added N,N-diisopropylethylamine (3.0 mmol)and the carbamoyl chloride (1.1 mmol). The resulting mixture washeated to reux until judged complete by TLC or HPLC, cooled to rtand concentrated under reduced pressure. Conc. HCl (4.0 mmol)was added to neutralize base and the mixture was extracted withEtOAc. The combined organics were dried (MgSO4), ltered, andconcentrated to give the crude product as a solid mass. The materialwas puried by recrystallization from EtOAc/hexanes to give nalproduct as a crystalline solid. |