[ CAS No. 2680-03-7 ] {[proInfo.proName]}

Name: 2680-03-7|N,N-Dimethylacrylamide|97% (stabilized with MEHQ)
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SKU: A514826
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Quality Control of [ 2680-03-7 ]

COA NMR CNMR HPLC LC-MS

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Product Details of [ 2680-03-7 ]

CAS No. :	2680-03-7	MDL No. :	MFCD00008626
Formula :	C₅H₉NO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	YLGYACDQVQQZSW-UHFFFAOYSA-N
M.W :	99.13	Pubchem ID :	17587
Synonyms :

Calculated chemistry of [ 2680-03-7 ]

Physicochemical Properties

Num. heavy atoms :	7
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.4
Num. rotatable bonds :	2
Num. H-bond acceptors :	1.0
Num. H-bond donors :	0.0
Molar Refractivity :	28.77
TPSA :	20.31 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.68 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.62
Log Po/w (XLOGP3) :	0.31
Log Po/w (WLOGP) :	0.26
Log Po/w (MLOGP) :	0.38
Log Po/w (SILICOS-IT) :	-0.1
Consensus Log Po/w :	0.49

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-0.52
Solubility :	30.1 mg/ml ; 0.303 mol/l
Class :	Very soluble
Log S (Ali) :	-0.3
Solubility :	49.8 mg/ml ; 0.502 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-0.3
Solubility :	49.1 mg/ml ; 0.495 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.04

Safety of [ 2680-03-7 ]

Signal Word:	Danger	Class:	6.1
Precautionary Statements:	P210-P264-P270-P280-P301+P310+P330-P302+P352+P312-P305+P351+P338+P310-P332+P313-P370+P378-P403+P235-P405-P501	UN#:	2810
Hazard Statements:	H227-H301+H311-H316-H318	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 2680-03-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 2680-03-7 ]
Downstream synthetic route of [ 2680-03-7 ]

[ 2680-03-7 ] Synthesis Path-Upstream 1~5

1
[ 2680-03-7 ]
[ 758-96-3 ]
[ 81733-98-4 ]

Reference： [1] Chemistry Letters, 1982, p. 361 - 364

2
[ 2680-03-7 ]
[ 201230-82-2 ]
[ 758-96-3 ]
[ 81733-98-4 ]

Reference： [1] Chemistry Letters, 1982, p. 361 - 364

3
[ 2680-03-7 ]
[ 758-96-3 ]

Reference： [1] Organic and Biomolecular Chemistry, 2014, vol. 12, # 28, p. 5082 - 5088
[2] Organometallics, 2016, vol. 35, # 7, p. 943 - 949

4
[ 2680-03-7 ]
[ 150-78-7 ]
[ 52428-09-8 ]

Reference： [1] Tetrahedron Letters, 1996, vol. 37, # 24, p. 4199 - 4202
[2] Tetrahedron, 1996, vol. 52, # 40, p. 12993 - 13006

5
[ 2680-03-7 ]
[ 634-36-6 ]
[ 16718-42-6 ]

Reference： [1] Tetrahedron, 1996, vol. 52, # 40, p. 12993 - 13006

[ 2680-03-7 ] Synthesis Path-Downstream 1~88

1
[ 17268-49-4 ]
[ 2680-03-7 ]

Reference： [1]Patent: DE752481,1939,
DRP/DRBP Org.Chem.,

2
[ 17268-49-4 ]
[ 121-44-8 ]
[ 2680-03-7 ]

Reference： [1]Patent: DE932964,1951,

3
[ 1187-59-3 ]
[ 74-88-4 ]
[ 2680-03-7 ]

Reference： [1]Bulletin of the Chemical Society of Japan,1987,vol. 60,p. 1021 - 1026

4
[ 2680-03-7 ]
[ 634-36-6 ]
[ 16718-42-6 ]

Reference： [1]Tetrahedron,1996,vol. 52,p. 12993 - 13006

5
[ 3172-56-3 ]
[ 2680-03-7 ]
5,6-Dihydro-cyclohepta[1,2-b;4,3-b']dithiophen-4-one [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1998,vol. 63,p. 6132 - 6136

6
[ 19056-41-8 ]
[ 2680-03-7 ]
N,N-dimethyl-3-(5-amino-2-methoxyphenyl)acrylamide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 1218 - 1235

7
[ 2680-03-7 ]
[ 2956-58-3 ]
[ 255375-05-4 ]
poly(N,N-dimethylacrylamide) [ No CAS ]

Reference： [1]Tetrahedron Letters,1999,vol. 40,p. 9167 - 9170

8
N-chloromethyl-N-methylacrylamide [ No CAS ]
[ 872-50-4 ]
[ 1187-59-3 ]
[ 2680-03-7 ]

Reference： [1]Journal of the Chemical Society. Perkin Transactions 2 (2001),2000,p. 2328 - 2336

9
[ 2680-03-7 ]
[ 1571-33-1 ]
[ 17431-39-9 ]

Reference： [1]Journal of the American Chemical Society,2003,vol. 125,p. 1484 - 1485

10
[ 2680-03-7 ]
[ 15214-89-8 ]
copolymer; monomer(s): N,N-dimethylacrylamide, 2-acrylamido-2-methylpropanesulfonic acid [ No CAS ]

Reference： [1]Macromolecules,2002,vol. 35,p. 2036 - 2041

11
[ 2680-03-7 ]
[ 3845-76-9 ]
[ 99349-68-5 ]
polymer; monomers: m-acrylamidophenylboronic acid, 9.5 percent; N,N-dimethylaminopropylacrylamide, 3.2 percent; N,N-dimethylacrylamide, 87.3 percent [ No CAS ]

Reference： [1]Pharmaceutical Research,1997,vol. 14,p. 289 - 293

12
[ 2680-03-7 ]
[ 3845-76-9 ]
[ 99349-68-5 ]
polymer, Mw 37000; monomers: m-acrylamidophenylboronic acid, 12.7 percent; N,N-dimethylaminopropylacrylamide, 6.4 percent; N,N-dimethylacrylamide, 80.9 percent [ No CAS ]

Reference： [1]Pharmaceutical Research,1997,vol. 14,p. 289 - 293

13
[ 2680-03-7 ]
[ 3845-76-9 ]
[ 99349-68-5 ]
polymer, Mw 34000; monomers: m-acrylamidophenylboronic acid, 10.7 percent; N,N-dimethylaminopropylacrylamide, 10.4 percent; N,N-dimethylacrylamide, 78.9 percent [ No CAS ]

Reference： [1]Pharmaceutical Research,1997,vol. 14,p. 289 - 293

14
[ 2680-03-7 ]
[ 3845-76-9 ]
[ 99349-68-5 ]
polymer; monomers: m-acrylamidophenylboronic acid, 13.0 percent; N,N-dimethylaminopropylacrylamide, 11.6 percent; N,N-dimethylacrylamide, 75.4 percent [ No CAS ]

Reference： [1]Pharmaceutical Research,1997,vol. 14,p. 289 - 293

15
[ 2680-03-7 ]
[ 3845-76-9 ]
[ 99349-68-5 ]
polymer; monomers: m-acrylamidophenylboronic acid, 11.2 percent; N,N-dimethylaminopropylacrylamide, 10.8 percent; N,N-dimethylacrylamide, 78.0 percent [ No CAS ]

Reference： [1]Pharmaceutical Research,1997,vol. 14,p. 289 - 293

16
[ 2680-03-7 ]
[ 3845-76-9 ]
[ 99349-68-5 ]
polymer; monomers: m-acrylamidophenylboronic acid, 10.6 percent; N,N-dimethylaminopropylacrylamide, 16.1 percent; N,N-dimethylacrylamide, 73.3 percent [ No CAS ]

Reference： [1]Pharmaceutical Research,1997,vol. 14,p. 289 - 293

17
[ 2680-03-7 ]
[ 2956-58-3 ]
4-(2-aminoethyl)styrene hydrochloride [ No CAS ]
polymer, reverse-phase suspension copolymerization, NH2 content 932 μmol/g; monomer(s): 4-(2-aminoethyl)styrene hydrochloride; N,N-dimethylacrylamide; N,N-ethylenebisacrylamide [ No CAS ]

Reference： [1]Tetrahedron,2004,vol. 60,p. 11407 - 11414

18
[ 2680-03-7 ]
[ 2956-58-3 ]
4-aminomethylstyrene hydrochloride [ No CAS ]
polymer, reverse-phase suspension copolymerization, NH2 content 696 μmol/g; monomer(s): 4-aminomethylstyrene hydrochloride; N,N-dimethylacrylamide; N,N-ethylenebisacrylamide [ No CAS ]

Reference： [1]Tetrahedron,2004,vol. 60,p. 11407 - 11414

19
[ 2680-03-7 ]
[ 2956-58-3 ]
4-(4-aminobutyl)styrene hydrochloride [ No CAS ]
polymer, reverse-phase suspension copolymerization, NH2 content 894 μmol/g; monomer(s): 4-(4-aminobutyl)styrene hydrochloride; N,N-dimethylacrylamide; N,N-ethylenebisacrylamide [ No CAS ]

Reference： [1]Tetrahedron,2004,vol. 60,p. 11407 - 11414

20
[ 2680-03-7 ]
[ 2956-58-3 ]
4-(6-aminohexyl)styrene hydrochloride [ No CAS ]
polymer, reverse-phase suspension copolymerization, monomer(s): 4-(6-aminohexyl)styrene hydrochloride; N,N-dimethylacrylamide; N,N\-ethylenebisacrylamide [ No CAS ]

Reference： [1]Tetrahedron,2004,vol. 60,p. 11407 - 11414

21
[ 2680-03-7 ]
[ 2956-58-3 ]
2-methoxy-6-[(4-vinyl)benzyloxy]benzylamine hydrochloride [ No CAS ]
polymer, reverse-phase suspension copolymerization, NH2 content 305 μmol/g; monomer(s): 2-methoxy-6-[(4-vinyl)benzyloxy]benzylamine hydrochloride; N,N-dimethylacrylamide; N,N-ethylenebisacrylamide [ No CAS ]

Reference： [1]Tetrahedron,2004,vol. 60,p. 11407 - 11414

22
[ 2680-03-7 ]
[ 99349-68-5 ]
polymer; monomers: m-acrylamidophenylboronic acid, 11.0 percent; N,N-dimethylacrylamide, 89.0 percent [ No CAS ]

Reference： [1]Pharmaceutical Research,1997,vol. 14,p. 289 - 293

23
[ 2680-03-7 ]
[ 99349-68-5 ]
polymer, Mw 39000; monomers: m-acrylamidophenylboronic acid, 12.5 percent; N,N-dimethylacrylamide, 87.5 percent [ No CAS ]

Reference： [1]Pharmaceutical Research,1997,vol. 14,p. 289 - 293

24
[ 2680-03-7 ]
[ 13304-62-6 ]
1-benzyl-5-(N,N-dimethylcarbamoyl)piperidin-2-one [ No CAS ]
1-benzyl-5-(N-benzylcarbamoyl)piperidin-2-one [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2005,vol. 70,p. 3957 - 3962

25
[ 38862-24-7 ]
[ 2680-03-7 ]
[ 4369-14-6 ]
poly(N,N-dimethylacrylamide-co-N-acryloyloxysuccinimide-co-3-(trimethoxysilyl)propyl methacrylate), M_w: 150000, I_d: 3.2 [ No CAS ]

Reference： [1]Analytical Chemistry,2004,vol. 76,p. 1352 - 1358

26
[ 38862-24-7 ]
[ 2680-03-7 ]
poly(N,N-dimethylacrylamide-co-N-acryloyloxysuccinimide), M_w: 120000, I_d: 3.4 [ No CAS ]

Reference： [1]Analytical Chemistry,2004,vol. 76,p. 1352 - 1358

27
2-(acrylamido)-2-methylpropanesulfonic acid [ No CAS ]
[ 110-26-9 ]
[ 2680-03-7 ]
polymer, crosslinked; monomer(s): 2-(acrylamido)-2-methylpropanesulfonic acid; N,N-dimethylacrylamide; N_.N\-methylenebisacrylamide [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 427 - 429

28
(trimethylsilyl)propargyl acrylamide [ No CAS ]
[ 292638-84-7 ]
[ 2680-03-7 ]
[ 17407-09-9 ]
polymer; monomer(s): styrene; (trimethylsilyl)propargyl acrylamide; N-t-butyl-N-(2-methyl-1-phenylpropyl)-O-(1-phenylethyl)hydroxylamine; 2-trimethylsiloxyethyl methacrylate; N,N-dimethylacrylamide [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 14942 - 14949

29
[ 38862-24-7 ]
[ 2680-03-7 ]
poly(N,N-dimethylacrylamide-st-N-(acryloyloxy)succinimide), M_n 251600 Da, M_w 551900 Da GPC; monomer(s): N,N-dimethylacrylamide; N-(acryloyloxy)succinimide [ No CAS ]

Reference： [1]Macromolecules,2003,vol. 36,p. 8119 - 8129

30
[ 2680-03-7 ]
[ 2001-45-8 ]
[ 17431-39-9 ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 6166 - 6169

31
[ 2680-03-7 ]
[ 201611-92-9 ]
poly(N,N-dimethylacrylamide), M_n 8200, M_w/M_n 1.08, product of RAFT polymerization with 4-carboxy-2-cyanobutyl-2-yl dithiobenzoate; monomer(s): N,N-dimethylacrylamide; 4-carboxy-2-cyanobutyl-2-yl dithiobenzoate [ No CAS ]

Reference： [1]Macromolecules,2004,vol. 37,p. 2728 - 2737

32
[ 2680-03-7 ]
[ 56467-43-7 ]
polymer, M_w 155000 Da, M_w/M_n 2.5; monomer(s): N,N-dimethylacrylamide; 4-methacryloyloxybenzophenone [ No CAS ]

Reference： [1]Macromolecules,2004,vol. 37,p. 882 - 887

33
[ 2680-03-7 ]
[ 56467-43-7 ]
polymer, M_w 113000 Da, M_w/M_n 3.3; monomer(s): N,N-dimethylacrylamide; 4-methacryloyloxybenzophenone, 1.0 mol percent [ No CAS ]

Reference： [1]Macromolecules,2004,vol. 37,p. 882 - 887

34
[ 38862-24-7 ]
[ 2680-03-7 ]
polymer, M_n 251600 Da, M_w/M_n 2.20, radical polymerization, N,N-dimethylacrylamide content 98 mol %, N-acryloyloxysuccinimide content 2 mol %; monomer(s): N,N-dimethylacrylamide; N-acryloyloxysuccinimide [ No CAS ]

Reference： [1]Macromolecules,2005,vol. 38,p. 10799 - 10811

35
[ 38862-24-7 ]
[ 2680-03-7 ]
polymer, M_n 49200 Da, M_w/M_n 1.21, RAFT polymerization, N,N-dimethylacrylamide content 77 mol %, N-acryloyloxysuccinimide content 23 mol %; monomer(s): N,N-dimethylacrylamide; N-acryloyloxysuccinimide [ No CAS ]

Reference： [1]Macromolecules,2005,vol. 38,p. 10799 - 10811

36
[ 2680-03-7 ]
[ 698-67-9 ]
N-[N',N'-dimethylamino-(Z)-propenoyl]-4-bromobenzamide [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2006,vol. 128,p. 12954 - 12962

37
[ 2680-03-7 ]
[ 621-79-4 ]
N-[N',N'-dimethylamino-(Z)-propenoyl]-3-phenyl-2-(E)-propenonamide [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2006,vol. 128,p. 12954 - 12962

38
[ 2680-03-7 ]
[ 79-39-0 ]
N-[N',N'-dimethylamino-(Z)-propenoyl]-2-methyl-2-propenonamide [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2006,vol. 128,p. 12954 - 12962

39
[ 38862-24-7 ]
[ 2680-03-7 ]
polymer; monomers: N-isopropylacrylamide; N-acryloxysuccinimide [ No CAS ]

Reference： [1]Tetrahedron Letters,2007,vol. 48,p. 6660 - 6664

40
[ 110-26-9 ]
[ 2680-03-7 ]
[ 7446-81-3 ]
copolymer, cross-linked with N,N'-methylenebiscrylamide; monomer(s): sodium acrylate, 5 mol %; N,N-dimethylacrylamide; N,N'-methylenebisacrylamide [ No CAS ]

Reference： [1]Journal of Physical Chemistry B,2005,vol. 109,p. 4258 - 4262

41
[ 110-26-9 ]
[ 2680-03-7 ]
[ 7446-81-3 ]
copolymer, cross-linked with N,N'-methylenebiscrylamide; monomer(s): sodium acrylate, 10 mol %; N,N-dimethylacrylamide; N,N'-methylenebisacrylamide [ No CAS ]

Reference： [1]Journal of Physical Chemistry B,2005,vol. 109,p. 4258 - 4262

42
[ 110-26-9 ]
[ 2680-03-7 ]
[ 7446-81-3 ]
copolymer, cross-linked with N,N'-methylenebiscrylamide; monomer(s): sodium acrylate, 20 mol %; N,N-dimethylacrylamide; N,N'-methylenebisacrylamide [ No CAS ]

Reference： [1]Journal of Physical Chemistry B,2005,vol. 109,p. 4258 - 4262

43
[ 2680-03-7 ]
[ 1760-24-3 ]
C₁₃H₃₁N₃O₄Si [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98%	at 70 - 100℃; for 8.5h;	A four neck flask equipped with a thermometer, stirrer, and cooler, was filled with 222.4 parts by weight of N- (2-aminoethyl)-3-aminopropyltrimethoxysilane, and the content of the flask was heated in A nitrogenous atmosphere to 70 C. Then, 109.0 parts by weight of N, N-dimethylacrylamide was added dropwise over 30 minutes, and the mixture was stirred and heated for 8 hours at 100 C. The reaction mixture was distilled under a reduced pressure at 130C and 1.3 hPa to produce 324.8 parts by weight of a yellowish transparent liquid, at a yield of 98 percent. Results of 13 C nuclear magnetic resonance spectral analysis (NM R), and infrared analysis (IR), defined the product as a nitrogen-containing organosilicon compound of the formula (C H3) 2N C O C2H4NH C2H4NH C3H6SI (O C H3) 3.

Reference： [1]Patent: WO2004/87719,2004,A1 .Location in patent: Page 12

44
[ 61790-90-7 ]
[ 2680-03-7 ]
[ 2495-35-4 ]
[ 2495-37-6 ]
cured film [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With 2,5-dimethyl-2,5-di(2-ethyl hexanoyl peroxy)-hexane; at 75℃; for 2h;	A mix consisting of the prepolymer of Example 3, benzyl acrylate, <strong>[2495-37-6]benzyl methacrylate</strong> andN, N,-dimethylacrylamide at a weight ratio of 50/20/10/20 is prepared. To the mix is added Lupersol256 tu (Atochem) at 1 <Desc/Clms Page number 16>percent of the total weigh. The mix is then cured between two silane-treated glass plates in an oven at 75 C for 2 hours. The cured films are then released, extracted in isopropanol for over 4 hours and dried in a vacuum oven at 70 C overnight. All dried films are then placed in a borate buffered saline overnight before characterization. Films of different thickness can be made in this manner. To mimic actual uses, films of 600 to 1000 microns in thickness should be made and the UV-VIS transmittance measured. With 0.15 % by weight of dye moiety in the film, the UV-VIS transmittance should be less than approximately 50 to 60 percent at 450 nm.

Reference： [1]Patent: WO2005/26182,2005,A1 .Location in patent: Page/Page column 15-16

45
[ 2680-03-7 ]
[ 3375-31-3 ]
[ 6163-58-2 ]
[ 143322-57-0 ]
(R)-5-trans-(2-N,N-Dimethylaminocarbonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
47%	With triethylamine; In acetonitrile;	A. (R)-5-trans-(2-N,N-Dimethylaminocarbonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole A mixture of N,N-dimethylacrylamide (134 muL, 1.3 mmol), tri-o-tolylphosphine (91 mg, 0.3 mmol), palladium (II) acetate (15 mg, 0.07 mmol), triethylamine (280 muL, 2 mmol) and <strong>[143322-57-0](R)-5-bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole</strong> was dissolved in anhydrous acetonitrile (5 mL) and refluxed for 24 hours under nitrogen. The reaction was partitioned between ethyl acetate and aqueous sodium carbonate. The dried (Na2 SO4) organic phase was evaporated and the residue purified by column chromatography on silica gel, eluding with CH2 Cl2: MeOH: NH4 OH 96:3.5:0.5 to afford the title compound as a white foam (145 mg, 47%). Anal. Calcd for C19 H25 N3 O·1/9 CH2 Cl2: C, 71.56; H, 7.87; N, 13.10 %. Found: C,71.29; H,8.15; N,13.05.
47%	With triethylamine; In acetonitrile;	A. (R)-5-trans-(2-N,N-Dimethylaminocarbonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole A mixture of N,N-dimethylacrylamide (134 muL, 1.3 mmol), tri-o-tolylphosphine (91 mg, 0.3 mmol), palladium (II) acetate (15 mg, 0.07 mmol), triethylamine (280 muL, 2 mmol) and <strong>[143322-57-0](R)-5-bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole</strong> was dissolved in anhydrous acetonitrile (5 mL) and refluxed for 24 hours under nitrogen. The reaction was partitioned between ethyl acetate and aqueous sodium carbonate. The dried (Na2 SO4) organic phase was evaporated and the residue purified by column chromatography on silica gel, eluding with CH2 Cl2:MeOH:NH4 OH 96:3.5:0.5 to afford the title compound as a white foam (145 mg, 47%). Anal. Calcd for C19 H25 N3 O· 1/9CH2 Cl2: C,71.56; H,7.87; N,13.10%. Found: C,71.29; H,8.15; N,13.05.
47%	With triethylamine; In acetonitrile;	A. (R)-5-trans-(2-N,N-Dimethylaminocarbonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole A mixture of N,N-dimethylacrylamide (134 muL, 1.3 mmol), tri-o-tolylphosphine (91 mg, 0.3 mmol), palladium (II) acetate (15 mg, 0.07 mmol), triethylamine (280 muL, 2 mmol) and <strong>[143322-57-0](R)-5-bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole</strong> was dissolved in anhydrous acetonitrile (5 mL) and refluxed for 24 hours under nitrogen. The reaction was partitioned between ethyl acetate and aqueous sodium carbonate. The dried (Na2 SO4) organic phase was evaporated and the residue purified by column chromatography on silica gel, eluding with CH2 Cl2: MeOH: NH4 OH 96:3.5:0.5 to afford the title compound as a white foam (145 mg, 47%). Anal. Calcd for C19 H25 N3 O*1/9 CH2 Cl2: C,71.56; H,7.87; N,13.10%. Found: C,71.29; H,8.15; N,13.05.

47%	With triethylamine; In acetonitrile;	A. (R)-5-trans-(2-N,N-Dimethylaminocarbonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole A mixture of N,N-dimethylacrylamide (134 muL, 1.3mmol), tri-o-tolylphosphine (91 mg, 0.3 mmol), palladium (II) acetate (15 mg, 0.07 mmol), triethylamine (280 muL, 2 mmol) and <strong>[143322-57-0](R)-5-bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole</strong> was dissolved in anhydrous acetonitrile (5 mL) and refluxed for 24 hours under nitrogen. The reaction was partitioned between ethyl acetate and aqueous sodium carbonate. The dried (Na2 SO4) organic phase was evaporated and the residue purified by column chromatography on silica gel, eluding with CH2 Cl2: MeOH: NH4 OH 96:3.5:0.5 to afford the title compound as a white foam (145 mg, 47%). Anal. Calcd for C19 H25 N3 O·1/9 CH2 Cl2: C,71.56; H,7.87; N,13.10%. Found: C,71.29; H,8.15; N,13.05.
47%	With triethylamine; In acetonitrile;	A. (R)-5-trans-(2-N,N-Dimethylaminocarbonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole A mixture of N,N-dimethylacrylamide (134 muL, 1.3 mmol), tri-o-tolylphosphine (91 mg, 0.3 mmol), palladium (II) acetate (15 mg, 0.07 mmol), triethylamine (280 muL, 2 mmol) and <strong>[143322-57-0](R)-5-bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole</strong> was dissolved in anhydrous acetonitrile (5 mL) and refluxed for 24 hours under nitrogen. The reaction was partitioned between ethyl acetate and aqueous sodium carbonate. The dried (Na2 SO4) organic phase was evaporated and the residue purified by column chromatography on silica gel, eluding with CH2 Cl2: MeOH: NH4 OH 96:3.5:0.5 to afford the title compound as a white foam (145 mg, 47%). Anal. Calcd for C19 H25 N3 O. 1/9 CH2 Cl2: C, 71.56; H, 7.87; N, 13.10%. Found: C, 71.29; H, 8.15; N, 13.05.

Reference： [1]Patent: US5545644,1996,A
[2]Patent: US5578612,1996,A
[3]Patent: US5559246,1996,A
[4]Patent: US5559129,1996,A
[5]Patent: US5607951,1997,A

46
[ 2680-03-7 ]
[ 123843-65-2 ]
C₁₂H₁₃F₂NO₂ [ No CAS ]
C₁₂H₁₅F₂NO₂ [ No CAS ]

Reference： [1]Organic Letters,2010,vol. 12,p. 992 - 995

47
[ 2680-03-7 ]
[ 201230-82-2 ]
[ 907943-71-9 ]
[ 1242056-82-1 ]
C₁₀H₂₀N₂O₂ [ No CAS ]

Reference： [1]Advanced Synthesis and Catalysis,2010,vol. 352,p. 1047 - 1054

48
[ 3581-87-1 ]
[ 2680-03-7 ]
tert-butyl (E)-3-(2-methylthiazol-5-yl)acrylate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2010,vol. 75,p. 5421 - 5424

49
[ 2680-03-7 ]
[ 18640-74-9 ]
[ 1236376-47-8 ]

Reference： [1]Journal of Organic Chemistry,2010,vol. 75,p. 5421 - 5424

50
sodium {3-aminooxalyl-2-methyl-1-[2-(pyrazole-1-carbothioylsulfanyl)propionyl]-1H-indol-4-yloxy}-acetate [ No CAS ]
[ 2680-03-7 ]
[ 141-32-2 ]
[ 2956-58-3 ]
poly(n-butyl acrylate-co-dimethyl acrylamide-co-ethylene bis-diacrylamide-co-sodium {3-aminooxalyl-2-methyl-1-[2-(pyrazole-1-carbothioylsulfanyl)propionyl]-1H-indol-4-yloxy}-acetate) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 5: SYNTHESIS OF POLYMER-LINKED INHIBITORS WITH GRAFT COPOLYMERS: SYNTHESIS OF STAR COPOLYMER OF (1-ACRYLOYL-3- AMINOOXALYL-2-METHYL-1 H-lNDOL-4-YLOXY)-ACETIC ACID, N-BUTYL ACRYLATE, DIMETHYL ACRYLAMIDE, AND N-(2-ACRYLOYLAMINO-ETHYL)-ACRYLAMIDE.[00352] This example describes approaches for synthesizing a phospholipase inhibitor comprising an oligomer or polymer moiety covalently linked to an inhibiting moiety, where the polymer moiety is linked using graft copolymers. In particular, a scheme is provided for synthesis of a star copolymer of (1-Acryloyl-3-aminooxalyl-2-methyl-1 H-indol-4-yloxy)-acetic acid, n-butyl acrylate, dimethyl acrylamide, and N-(2-Acry.oylamino-ethyl)-acrylamide.[00353] The synthesis scheme and the polymer formed thereby can be represented by the schematic representation: <n="142"/>A mixture of 26, dimethyl acrylamide, and n-butyl acrylate in a mole ratio of 0.04 : 0.48 : 0.48 (in total 10 mmol) is dissolved in 20 ml_ of DMF. To the mixture AIBN (2,2'- azobisisobutyronitrile, 10 mmol % to compound 26) is added and is heated to 75 0C for 8 hours. To the resulted yellow solution 1 mmol of dimethyl acrylamide and ethylene bis- diacrylamide (1 :1 ) is added and stirred for an additional 8 hours. After the reaction is cooled to rt, the reaction mixture is precipitated twice, dried under reduced pressure to obtain the copolymer.

Reference： [1]Patent: WO2007/56279,2007,A2 .Location in patent: Page/Page column 140-141

51
[ 2680-03-7 ]
[ 6971-74-0 ]
[ 1267588-56-6 ]

Yield	Reaction Conditions	Operation in experiment
82%	With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate; In toluene; at 130℃; for 24h;Inert atmosphere;	General procedure: N-Benzoylsulfonamide 1a (27.5 mg, 0.1 mmol), [RhCl2Cp*]2 (1.2 mg, 0.002 mmol), and Cu(OAc)2·H2O (40.0 mg, 0.20 mmol) were loaded in a dry vial, which was subjected to evacuation/flushing with dry argon three times. Anhydrous toluene (1.0 mL) solution of tert-butyl acrylate 2a (17.4 muL, 0.12 mmol) was syringed into the mixture, which was then stirred at 130 C for 24 h or until the starting material had been consumed as determined by TLC. Upon cooling to room temperature, all volatiles were evaporated and the residue was purified by preparative TLC (ethyl acetate/hexane 1:2) to give isoindolinone 3a in 88% yield

Reference： [1]Organic Letters,2011,vol. 13,p. 1214 - 1217
[2]Tetrahedron,2012,vol. 68,p. 9192 - 9199

52
[ 1131-61-9 ]
[ 2680-03-7 ]
[ 1380324-66-2 ]

Reference： [1]Angewandte Chemie - International Edition,2012,vol. 51,p. 3677 - 3681

53
[ 1131-61-9 ]
[ 2680-03-7 ]
C₁₆H₁₈N₂O₂ [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2012,vol. 51,p. 3677 - 3681

54
[ 2680-03-7 ]
[ 7223-30-5 ]
[ 1392485-91-4 ]

Reference： [1]Angewandte Chemie - International Edition,2012,vol. 51,p. 5696 - 5700

55
[ 3034-31-9 ]
[ 2680-03-7 ]
[ 1389293-09-7 ]

Reference： [1]Organic and Biomolecular Chemistry,2012,vol. 10,p. 5521 - 5524

56
[ 1271-86-9 ]
[ 2680-03-7 ]
C₁₈H₂₄FeN₂O [ No CAS ]

Reference： [1]Chemical Science,2013,vol. 4,p. 2675 - 2679

57
[ 2680-03-7 ]
[ 14814-09-6 ]
[ 1459802-38-0 ]

Yield	Reaction Conditions	Operation in experiment
90%	With triethylamine; In ethanol; at 20℃; for 48h;	To a stirred solution of 3-(mercaptopropyl) triethoxysilane (30 mmol) in 50 mL of anhydrous ethanol was added N,N-dimethylacrylamide (30 mmol) at ambient temperature. To the solution of reactants was added triethylamine (30 mmol) and resulting solution was stirred at ambient temperature for 48h. The mixture was concentrated under reduced pressure and dried overnight in Schlenk line. The product was obtained in 90% yield. The synthesized compound was characterized via 1H-NMR (400 MHz) and HPLC (88.4% purity). The chemical structures were characterized via NMR (400 MHz) as shown in Figure 1.
90%	With triethylamine; In ethanol;	To a stirred solution of 3-(mercaptopropyl)triethoxysilane (30 mmol) in 50 mL of anhydrous ethanol was added N,N-dimethylacrylamide (30 mmol) at ambient temperature. To the solution of reactants was added triethylamine (30 mmol) and resulting solution was stirred at ambient temperature for 48 h. The mixture was concentrated under reduced pressure and dried overnight in Schlenk line. The product was obtained in 90% yield. The synthesized compound was characterized via 1H-NMR (400 MHz) and HPLC (88.4% purity). The chemical structures were characterized via NMR (400 MHz) as shown in .

Reference： [1]Patent: EP2644610,2013,A1 .Location in patent: Paragraph 0052; 0053
[2]Patent: US8993669,2015,B2 .Location in patent: Page/Page column

58
[ 5446-92-4 ]
[ 2680-03-7 ]
[ 1465907-29-2 ]

Reference： [1]Organometallics,2013,vol. 32,p. 6565 - 6575

59
[ 6231-18-1 ]
[ 2680-03-7 ]
[ 1465907-31-6 ]

Reference： [1]Organometallics,2013,vol. 32,p. 6565 - 6575

60
[ 38862-24-7 ]
[ 2680-03-7 ]
Sodium tripolyphosphate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In tetrahydrofuran;	EXAMPLE 4 Synthesis of poly (N,N-dimethylacrylamide-co-N-acryloyloxysuccinimide-co-N,N,N-trimethylaminoethylacrylamide). The synthetic path is the same as for [DMA98-co-NAS2]: N,N-dimethylacrylamide (600 mg, 6,15 mmols), N-acryloyloxysuccinimide (20.7 mg, 0.12 mmols) and N,N,N-trimethylaminoethylacrylamide (47 mg (0.3 mmols) in 6 ml of anhydrous tetrahydrofuran (THF).

Reference： [1]Patent: US2015/87555,2015,A1 .Location in patent: Page/Page column

61
[ 353-83-3 ]
[ 2680-03-7 ]
[ 31599-60-7 ]
C₁₅H₁₈F₃NO [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2014,vol. 53,p. 10174 - 10178
Angew. Chem.,2014,vol. 126,p. 10338 - 10342,5

62
[ 353-83-3 ]
[ 2680-03-7 ]
[ 42048-11-3 ]
C₁₄H₁₅ClF₃NO [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2014,vol. 53,p. 10174 - 10178
Angew. Chem.,2014,vol. 126,p. 10338 - 10342,5

63
[ 353-83-3 ]
[ 2680-03-7 ]
[ 5471-81-8 ]
C₁₆H₁₈F₃NO₃ [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2014,vol. 53,p. 10174 - 10178
Angew. Chem.,2014,vol. 126,p. 10338 - 10342,5

64
[ 2680-03-7 ]
[ 1314538-55-0 ]
[ 154656-95-8 ]

Reference： [1]Advanced Synthesis and Catalysis,2014,vol. 356,p. 2749 - 2755

65
[ 2680-03-7 ]
[ 201611-92-9 ]
PDMA₅₈ [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2016,vol. 138,p. 3094 - 3106

66
[ 2680-03-7 ]
[ 57479-70-6 ]
2-(6-chloro-4-methoxy-3-oxo-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylacetamide [ No CAS ]

Reference： [1]Chemistry - An Asian Journal,2016,vol. 11,p. 356 - 359

67
[ 3796-24-5 ]
[ 2680-03-7 ]
N,N-dimethyl-2-(4-(trifluoromethyl)pyridin-2-yl)propanamide [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2017,vol. 56,p. 5899 - 5903
Angew. Chem.,2017,vol. 129,p. 5993 - 5997,5

68
[ 2680-03-7 ]
[ 81565-19-7 ]
2-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)-N,N-dimethylpropanamide [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2017,vol. 56,p. 5899 - 5903
Angew. Chem.,2017,vol. 129,p. 5993 - 5997,5

69
[ 3796-23-4 ]
[ 2680-03-7 ]
N,N-dimethyl-3-(5-(trifluoromethyl)pyridin-2-yl)propanamide [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2017,vol. 56,p. 5899 - 5903
Angew. Chem.,2017,vol. 129,p. 5993 - 5997,5

70
[ 3796-23-4 ]
[ 2680-03-7 ]
N,N-dimethyl-2-(5-(trifluoromethyl)pyridin-2-yl)propanamide [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2017,vol. 56,p. 5899 - 5903
Angew. Chem.,2017,vol. 129,p. 5993 - 5997,5

71
[ 40851-91-0 ]
[ 2680-03-7 ]
C₁₁H₁₃N₃O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
43%	With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; triethylamine; In N,N-dimethyl-formamide; at 100℃;Inert atmosphere;	In a Shlenck reactor, to a solution of <strong>[40851-91-0]6-chloro-2-methoxy-3-nitropyridine</strong> (1.00 g, 5.30 mmol) in DMF (50 mL), 1VN-dimethylacrylamide (820.00 jiL, 7.96 mmol) and TEA (2.21 mL, 15.90 mmol) were added. The mixture was degassed under N2 and [1,1?- bis(diphenylphosphino)ferrocene] dichloropalladium (II), complex withdichloromethane (434.00 mg, 0.53 mmol) was added. The mixture was degassed again with N2 and stirred at 100 C overnight. The mixture was evaporated in vacuo. The residue was taken-up in EtOAc and brine and filtered on a pad of celite. The cake was washed with EtOAc. The layers were separated and the organic layer was washed with brine. The organic layer was dried over Mg504, filtered off and evaporated in vacuo togive a black solid. The residue (2.4 g) was purified by column chromatography on silica gel (irregular SiOH, 15-40 jim, 50 g, dry loading on celite, mobile phase:heptane/EtOAc/MeOH, gradient: from heptane 70%, EtOAc 27%, MeOH 3% to heptane 40%, EtOAc 54%, MeOH 6%). The pure fractions were combined and evaporated to dryness to give 566 mg of intermediate 154 (43% yield, orange solid).

Reference： [1]Patent: WO2017/125534,2017,A1 .Location in patent: Page/Page column 274

72
[ 2680-03-7 ]
[ 34552-14-2 ]
C₁₁H₁₅N₃O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
71%	With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); triethylamine; In N,N-dimethyl-formamide; at 140℃;Inert atmosphere;	In a microwave vial, a suspension of <strong>[34552-14-2]3-amino-2-bromo-5-methylpyridine</strong> (500.00 mg,2.67 mmol), N,N-dimethylacrylamide (689.00 jiL, 6.68 mmol), bis(di-tert-butyl(4-dimethylaminophenyl)phosphine) palladium (II) dichloride (94.60 mg, 0.13 mmol) and TEA (1.12 mL, 8.02 mmol) in DMF (12.5 mL) was purged with N2 and was heated at 140 C using one single mode microwave (Biotage Initiator) with a power output ranging from 0 to 400 W for 30 mm [fixed hold time]. This reaction was performed in two batches from 500 mg of <strong>[34552-14-2]3-amino-2-bromo-5-methylpyridine</strong> each. These twobatches were combined and evaporated in vacuo. The residue was taken-up in EtOAc and water. The layers were separated and the aqueous layer was extracted twice with EtOAc and twice with DCM. The aqueous layer was saturated with K2C03 and extracted twice with a mixture of DCM/MeOH (9:1). The combined organic layers were dried over MgSO4, filtered off and evaporated in vacuo to give a brown solid. The residue (2.2 g) was purified by column chromatography on silica gel (irregular SiOH,15-40 jim, 80 g, dry loading on celite, mobile phase: heptane/(EtOAc/MeOH (9:1)), gradient: from 70:30 to 15:85). The pure fractions were combined to give 815 mg of intermediate 271 (71% yield, yellow solid).

Reference： [1]Patent: WO2017/125534,2017,A1 .Location in patent: Page/Page column 284; 285

73
[ 2680-03-7 ]
[ 34535-98-3 ]
N,N-dimethyl-2-(phenylamino)cyclopentanecarboxamide [ No CAS ]
N,N-dimethyl-2-(phenylamino)cyclopentanecarboxamide [ No CAS ]

Reference： [1]Organic Letters,2018,vol. 20,p. 2693 - 2697

74
[ 2680-03-7 ]
[ 244090-34-4 ]
[ 74-88-4 ]
methyl (E)-4-(3-(dimethylamino)-3-oxoprop-1-en-1-yl)-1-phenyl-1H-indole-3-carboxylate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2018,vol. 83,p. 5639 - 5649

75
[ 43036-06-2 ]
[ 2680-03-7 ]
(E)-3-(1-(2-cyanoethyl)-1H-pyrrol-2-yl)-N,N-dimethylacrylamide [ No CAS ]

Reference： [1]Chemistry - An Asian Journal,2018,vol. 13,p. 2418 - 2422

76
[ 932-16-1 ]
[ 2680-03-7 ]
(E)-3-(5-acetyl-1-methyl-1H-pyrrol-2-yl)-N,N-dimethylacrylamide [ No CAS ]

Reference： [1]Chemistry - An Asian Journal,2018,vol. 13,p. 2418 - 2422

77
[ 2680-03-7 ]
[ 99163-12-9 ]
C₁₂₉H₁₆₇N₃₉O₆₆P₁₀ [ No CAS ]

Reference： [1]MedChemComm,2019,vol. 10,p. 1082 - 1093

78
[ 51417-51-7 ]
[ 2680-03-7 ]
(E)-3-(1H-indol-7-yl)-N,N-dimethylacrylamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	With palladium diacetate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 20 - 100℃;Inert atmosphere;	To a stirred solution of 7-bromo-lH-indole (0.46 g, 2.3 mmol) in dry DMF (2.6 ml) was added N,N-dimethylacrylamide (0.46 g, 4.6 mmol) at room temperature. To this mixture Pd(OAc)2 (0.010 g, 0.04 mmol), triphenyl phosphine (0.024 g, 0.1 mmol), and diisopropylethyl amine (0.5 ml, 2.9 mmol) were added at room temperature. The reaction mixture was then purged with argon gas for 20 minutes. Then it was heated to 100 C overnight. The reaction mixture was poured into ice cold water (50 ml) and extracted with ethyl acetate (3 x 50 ml). The combined organic layers were washed with brine (50 ml), dried over anhydrous Na2S04 and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography to afford the title compound (0.43 g, 85%) as light brown solid. 1H NMR (400 MHz, DMSO-d6): d 2.97 (s, 3H), 3.20 (s, 3H), 6.50 (s, 1H), 7.05 (t, J = 7.6 Hz, 1H), 7.24 (d, J = 15.2 Hz, 1H), 7.38 (t, J = 2.8 Hz, 1H), 7.56 - 7.63 (m, 2H), 7.96 (d, J = 8.0 Hz, 1H), 11.53 (s, 1H, -NH). LCMS: m/z = 215.3 [M+l]

Reference： [1]Patent: WO2019/161157,2019,A1 .Location in patent: Paragraph 00142-00143

79
[ 2680-03-7 ]
[ 74901-29-4 ]
4-hydroxy-3-methyl-2-oxo-2H-chromene-6-carbonitrile [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2019,vol. 17,p. 9275 - 9279

80
[ 2680-03-7 ]
[ 3328-70-9 ]
4-hydroxy-3-methyl-2-oxo-2H-chromene-6-carbaldehyde [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2019,vol. 17,p. 9275 - 9279

81
[ 2680-03-7 ]
[ 247940-06-3 ]
2-(dicyclohexylphosphino)-2’,6’-bis(3-(dimethylamino)-3-oxopropyl)biphenyl [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2019,vol. 58,p. 14110 - 14114
Angew. Chem.,2019,vol. 131,p. 14248 - 14252,5

82
[ 2680-03-7 ]
[ 247940-06-3 ]
2-(dicyclohexylphosphino)-2’(3-(dimethylamino)-3-oxopropyl)biphenyl [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2019,vol. 58,p. 14110 - 14114
Angew. Chem.,2019,vol. 131,p. 14248 - 14252,5

83
[ 2680-03-7 ]
[ 251320-86-2 ]
C₃₀H₄₂NOP [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2019,vol. 58,p. 14110 - 14114
Angew. Chem.,2019,vol. 131,p. 14248 - 14252,5

84
[ 2680-03-7 ]
[ 1211443-61-6 ]

Reference： [1]Patent: CN110372706,2019,A
[2]Patent: CN110407841,2019,A

85
[ 1455-20-5 ]
[ 2680-03-7 ]
[ 610-97-9 ]
C₂₁H₂₅NO₃S [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2019,vol. 141,p. 18958 - 18963

86
[ 2680-03-7 ]
[ 1374639-78-7 ]

Reference： [1]Patent: CN110407841,2019,A

87
[ 2680-03-7 ]
[ 1211441-98-3 ]

Reference： [1]Patent: CN110407841,2019,A

88
[ 1271-86-9 ]
[ 2680-03-7 ]
C₁₈H₂₄FeN₂O [ No CAS ]

Reference： [1]ACS Catalysis,2019,vol. 9,p. 11386 - 11397

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
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P103	Read label before use
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Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
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P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
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P233	Keep container tightly closed.
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P281	Use personal protective equipment as required.
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Code	Phrase
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P304	IF INHALED:
P305	IF IN EYES:
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P320
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P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 2680-03-7 ] {[proInfo.proName]}

Quality Control of [ 2680-03-7 ]

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[ 2680-03-7 ] Synthesis Path-Upstream 1~5

[ 2680-03-7 ] Synthesis Path-Downstream 1~88

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[ 2680-03-7 ]