Alternatived Products of [ 272-57-1 ]
Product Details of [ 272-57-1 ]
CAS No. : | 272-57-1 |
MDL No. : | MFCD18251004 |
Formula : |
C5H4N4
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
120.11
|
Pubchem ID : | - |
Synonyms : |
|
Application In Synthesis of [ 272-57-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 272-57-1 ]
- 1
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[ 3438-61-7 ]
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[ 272-57-1 ]
Yield | Reaction Conditions | Operation in experiment |
27% |
With potassium acetate; acetic anhydride; acetic acid; isopentyl nitrite; In toluene; for 2h;Reflux; |
To a solution of the reactant (109 mg, 1.0 mmol) in toluene (1.5 mL) was added acetic anhydride (0.2 mL, 2.10 mmol), acetic acid (0.2 mL, 3.5 mmol) followed by potassium acetate (196 mg, 2.0 mmol). The mixture was heated to reflux and isopentyl nitrire (0.168 mL, 1.25 mmol) in toluene (0.3 mL) was added. After 2 hours, the mixture was poured into water (20 mL). The solution was made basic by addition of Na2C03 solid. The solution was extracted with ethyl acetate (2x50 mL) and the combined organic extracts were washed with brine (50 mL), dried over magnesium sulfate and concentrated in vacuo. The residue was purified by silica gel chromatography (eluant:petroleum ether: ethyl acetate = 1 :2) to afford product product (32 mg, 0.266 mmol, Yield=27%) as yellow solid. 1H NMR (400 MHz, d6-DMSO) 5(ppm): 13.91 (1H, br), 9.35 (1H, s), 9.04 (1H, s), 8.45 (1H, s). |
- 2
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[ 20090-69-1 ]
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[ 272-57-1 ]