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[ CAS No. 27610-62-4 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 27610-62-4
Chemical Structure| 27610-62-4
Structure of 27610-62-4 *Storage: {[proInfo.prStorage]}

Quality Control of [ 27610-62-4 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 27610-62-4 ]

SDS

Product Details of [ 27610-62-4 ]

CAS No. :27610-62-4MDL No. :MFCD23135384
Formula :C5H3BrN4Boiling Point :-
Linear Structure Formula :-InChI Key :N/A
M.W :199.01Pubchem ID :-
Synonyms :

Computed Properties of [ 27610-62-4 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 27610-62-4 ]

Signal Word:WarningClass
Precautionary Statements:P261-P305+P351+P338UN#:
Hazard Statements:H302-H315-H319-H335Packing Group:
GHS Pictogram:

Application In Synthesis of [ 27610-62-4 ]

  • Downstream synthetic route of [ 27610-62-4 ]

[ 27610-62-4 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 626-55-1 ]
  • [ 27610-62-4 ]
  • C10H6BrN5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate; In toluene; for 2.0h;Reflux; Tri-tert-butylphosphine (4.4 mL of a 1.0 M solution in toluene,1.48g, 0.05mmol),Palladium acetate (0.4 g, 1.83 mmol)And sodium tert-butoxide (52.7 g, 549 mmol)Add to 8-6-a (14.61g, 73.42mmol)And 8-6-b (11.60g, 73.42mmol)a solution in degassed toluene (500 mL),And the mixture was heated under reflux for 2 hours.The reaction mixture was cooled to room temperature.Dilute with toluene and filter through celite.The filtrate was diluted with water.And extracted with toluene,And combining the organic phases,It was evaporated under vacuum.The residue was filtered over silica gel (heptane / dichloromethane).And crystallized from isopropanol.Obtaining compound 8-6-c;The resulting bromide 8-6-c (5.52 g, 20 mmol),Bornazolium diborate (6.22 g, 24 mmol),1,1'-bis(diphenylphosphino)-ferrocene-palladium(II) chloride complex(0.49g, 0.6mmol),Potassium acetate (5.90 g, 60 mmol) and 79 ml of toluene were reacted under reflux for 16 hours.cool down,Add 26ml of water,Stir for 30 minutes, separate the organic phase, filter through a short bed of diatomaceous earth, then evaporate the organic solvent to give the crude productRecrystallization from heptane / toluene gave compound 8-64.85 g, yield 75%.
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