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[ CAS No. 294182-06-2 ] {[proInfo.proName]}

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Chemical Structure| 294182-06-2
Chemical Structure| 294182-06-2
Structure of 294182-06-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 294182-06-2 ]

CAS No. :294182-06-2 MDL No. :
Formula : C13H6BrF4NO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 348.09 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 294182-06-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 294182-06-2 ]

[ 294182-06-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 348-57-2 ]
  • [ 77199-09-8 ]
  • [ 294182-06-2 ]
YieldReaction ConditionsOperation in experiment
43% With n-butyllithium; In diethyl ether; hexane; at -70 - 20℃; for 3.25h; To a stirred solution of 1-bromo-2,4-difluorobenzene (1.65 g, 8.57 mmol) in diethyl ether (Et20;10 mL) were added sequentially n-butyllithium (n-BuLi, 2.3 Molar (M) in hexane; 3.70 mL, 8.57mmol) at -70 C and the above ester (2.40 g, 8.57 mmol) in Et20 (5 mL) after 15 minutes (mm).The reaction mixture was stirred for 1 h at -70 C, warmed to RT and stirred for another 2 h. Thereaction mixture was quenched with aq NH4C1 solution and extracted with EtOAc (3 x 20 mL). The combined organic layers were washed with H20, washed with brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude compound was purified by column chromatography (eluting with EtOAc/hexane) to afford ketone B (1.30 g, 3.73 mmol, 43%) as ayellow liquid. ?H NMR (500 MHz, CDC13): oe8.62 (s, 1H), 8.08-8.04 (m, 2H), 7.74-7.70 (m, 1H),7.05-6.95 (m, 1H), 6.88-6.78 (m, 1H). MS(ESI): m/z 347, 349 [(M+1)+2].
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