Alternatived Products of [ 313724-26-4 ]
Product Details of [ 313724-26-4 ]
CAS No. : | 313724-26-4 |
MDL No. : | |
Formula : |
C15H18BrNO3
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
340.21
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 313724-26-4 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 313724-26-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 313724-26-4 ]
- 1
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[ 3951-89-1 ]
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[ 24424-99-5 ]
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[ 313724-26-4 ]
Yield | Reaction Conditions | Operation in experiment |
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With 4-dimethylaminopyridine In tetrahydrofuran for 1.5h; Heating; |
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With luitdine In tetrahydrofuran at 70℃; for 4h; |
2.3 Step 3: Synthesis of compound BB-1B-4
The reactants BB-1B-3 (6 g) and Boc anhydride (15.16 g) were dissolved in tetrahydrofuran (100 mL), and N,N-lutidine (4.58 g) was added to form a mixture. The mixture was stirred at 70°C for 4 hours, quenched with water (100 mL) and was extracted with ethyl acetate (100 mL×3). The combined organic layer was washed with saturated brine (100 mL), dried with anhydrous sodium sulfate, filtered and evaporated under reduced pressure to obtain a residue. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 50:1 to 20:1) to obtain BB-1B-4. MS-ESI (m/z): 283.9[M-55]+ |
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With luitdine In tetrahydrofuran at 70℃; for 4h; |
2.3 Step 3: Synthesis of compound BB-1B-4
The reactants BB-1B-3 (6 g) and Boc anhydride (15.16 g) were dissolved in tetrahydrofuran (100 mL), and N,N-lutidine (4.58 g) was added to form a mixture. The mixture was stirred at 70°C for 4 hours, quenched with water (100 mL) and was extracted with ethyl acetate (100 mL×3). The combined organic layer was washed with saturated brine (100 mL), dried with anhydrous sodium sulfate, filtered and evaporated under reduced pressure to obtain a residue. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 50:1 to 20:1) to obtain BB-1B-4. MS-ESI (m/z): 283.9[M-55]+ |
Reference:
[1]Seto, Masaki; Aramaki, Yoshio; Okawa, Tomohiro; Miyamoto, Naoki; Aikawa, Katsuji; Kanzaki, Naoyuki; Niwa, Shin-Ichi; Iizawa, Yuji; Baba, Masanori; Shiraishi, Mitsuru
[Chemical and Pharmaceutical Bulletin, 2004, vol. 52, # 5, p. 577 - 590]
[2]Current Patent Assignee: SHENZHEN LINGFANG BIO MEDICINE TECH; SHENZHEN LINGFANG BIOTECH; WUXI APPTEC CO., LTD. - EP3988098, 2022, A1
Location in patent: Paragraph 00077; 0081
[3]Current Patent Assignee: SHENZHEN LINGFANG BIO MEDICINE TECH; SHENZHEN LINGFANG BIOTECH; WUXI APPTEC CO., LTD. - EP3988098, 2022, A1
Location in patent: Paragraph 00077; 0081