There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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CAS No. : | 3185-73-7 | MDL No. : | MFCD24141223 |
Formula : | C13H9ClO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 232.66 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Danger | Class: | 6.1,8 |
Precautionary Statements: | P501-P260-P270-P262-P234-P271-P264-P280-P284-P390-P361+P364-P303+P361+P353-P301+P330+P331-P301+P310+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P406-P405 | UN#: | 3277 |
Hazard Statements: | H300+H310+H330-H314-H290 | Packing Group: | Ⅱ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
0.2973 g | With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 20℃; | To a solution of triphosgene (0.099 g, 0.33 mmol, 0.33 eq) in CH2Cl2 (10 mL), was slowly added 4-hydroxybiphenyl (0.1702 g, 1 mmol, 1 eq) and N,N-diisopropylethylamine (DIEA) (176 muL, 0.130 g, 1 mmol, 1 eq) as a solution in THF (10 mL). The reaction was stirred at room temperature for 30 min to generate the intermediate chloroformate. In a separate flask containing CH2Cl2 (10 mL), 2-methyl-4- piperazinoquinoline (0.3410 g, 1.5 mmol, 1.5 eq) was mixed with DIEA (263 muL, 0.195 g, 1.5 mmol, 1.5 eq). The mixture was stirred for 5 min at room temperature and then dropped into the flask containing the chloroformate. The reaction mixture was stirred at room temperature for another 30 min and partitioned between CH2Cl2 (50 mL) and saturated NH4Cl (50 mL). The organic layer was washed one more time with saturated NH4Cl (30 mL), dried over MgSO4 and filtered. The solvent was removed by rotary evaporation and the product was purified by silica gel column chromatography (1:1 ethyl acetate/hexanes) to afford JMN4 (0.2973 g, 0.702 mmol, 70%). |