Alternatived Products of [ 319-39-1 ]
Product Details of [ 319-39-1 ]
CAS No. : | 319-39-1 |
MDL No. : | MFCD00018259 |
Formula : |
C13H9Cl2NO
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
266.12
|
Pubchem ID : | - |
Synonyms : |
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Safety of [ 319-39-1 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 319-39-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 319-39-1 ]
- 1
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[ 2617-79-0 ]
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[ 319-39-1 ]
-
[ 18437-66-6 ]
-
[ 106-47-8 ]
-
[ 1219-99-4 ]
Yield | Reaction Conditions | Operation in experiment |
1: 23%
2: 3%
3: 4%
4: 27% |
With di-tert-butyl peroxide In chlorobenzene at 110℃; for 48h; Further byproducts given; |
|
1: 23%
2: 3%
3: 27%
4: 4% |
With di-tert-butyl peroxide; chlorobenzene at 110℃; for 48h; Further byproducts given; |
|
Reference:
[1]Leardini, Rino; Tundo, Antonio; Zanardi, Giuseppe
[Journal of the Chemical Society. Perkin transactions I, 1981, p. 3164 - 3167]
[2]Leardini, Rino; Tundo, Antonio; Zanardi, Giuseppe
[Journal of the Chemical Society. Perkin transactions I, 1981, p. 3164 - 3167]
- 2
-
[ 637-87-6 ]
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[ 609-66-5 ]
-
[ 319-39-1 ]
Yield | Reaction Conditions | Operation in experiment |
93% |
With potassium carbonate; N,N`-dimethylethylenediamine; In toluene; at 110℃; for 48h;Schlenk technique; Inert atmosphere; |
General procedure: An oven-dried Schlenk tube was charged with benzamide 1 (0.5 mmol), K2CO3 (207 mg, 1.5 mmol) and aryl iodide 2 (1.0 mol). The tube was evacuated and backfilled with N2 (3 ×), and then DMEDA (0.2 mmol) and anhyd toluene (5.0 mL) were added. The reaction mixture was stirred at 110 C for 48 h. H2O was added and the crude product was extracted with EtOAc. The combined organic phases were washed with brine and H2O, dried (Na2SO4), and concentrated under reduced pressure. The product was purified by silica gel chromatographyto give the desired N-arylated benzamides (Table 2). |