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Product Details of [ 33496-82-1 ]

CAS No. :	33496-82-1	MDL No. :	MFCD24688043
Formula :	C₉H₁₆O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	140.23	Pubchem ID :	-
Synonyms :

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Application In Synthesis of [ 33496-82-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 33496-82-1 ]
Downstream synthetic route of [ 33496-82-1 ]

[ 33496-82-1 ] Synthesis Path-Upstream 1~2

1
[ 78-59-1 ]
[ 116-02-9 ]
[ 33496-82-1 ]

Reference： [1] Synlett, 2009, # 19, p. 3143 - 3146

2
[ 78-59-1 ]
[ 470-99-5 ]
[ 116-02-9 ]
[ 33496-82-1 ]

Reference： [1] Synlett, 2009, # 19, p. 3143 - 3146
[2] Synlett, 2009, # 19, p. 3143 - 3146

[ 33496-82-1 ] Synthesis Path-Downstream 1~5

1
[ 78-59-1 ]
[ 33496-83-2 ]
[ 33496-82-1 ]

Yield	Reaction Conditions	Operation in experiment
1: 37.94% 2: 14.31%	With hydrogen In ethanol at 60℃; for 3h;	A CA-1, 24 g of ethanol solution and 0.84 g of IP was charged into a 100 mL high pressure reactor and the IMPa hydrogen was replaced by 4 times and then reacted at 40 ° C for 5 h under IMPa hydrogen. After the end of the reaction, the cooling was carried out and the high pressure reactor was opened. The product was centrifuged and the organic phase of the upper layer was quantitatively analyzed by gas chromatography on a gas chromatogram. Other reaction conditions: temperature 60 , pressure of 1MPa.
	With hydrogen In benzene at 50℃; for 20h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
	With pinacolborane; (-)-di-tert-butylmethoxy-segphos; [(Ph₃Pd)CuH] In toluene at 0℃; for 7.5h;

	With <i>L</i>-proline In methanol at 25℃; Title compound not separated from byproducts;
	With hydrogen In benzene at 50℃; for 45h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
	With hydrogen In benzene at 50℃; for 45h; selectivity of asymmetric hydrogenation; variation of temperature, time solvent, pressure; other α,β-unsaturated ketones;
	With 5% Pd/MgO; hydrogen; <i>L</i>-proline In methanol; hexan-1-ol at 25℃; for 20h; Inert atmosphere; Autoclave; optical yield given as %ee; stereoselective reaction;
54 % ee	With N-methylmaleimide reductase A from Pseudomonas putida; NADPH In aq. phosphate buffer; N,N-dimethyl-formamide at 30℃; for 12h; Enzymatic reaction; enantioselective reaction;
26 % ee	With tetrabutylammonium (R)-prolinate; hydrogen; palladium dichloride In isopropyl alcohol at 20℃; for 18h; Schlenk technique; Inert atmosphere; enantioselective reaction;
47 % ee	With hydrogen; palladium dichloride; proline, tetrabutylammonium carboxylate salt In isopropyl alcohol at 20℃; for 18h; Schlenk technique; Inert atmosphere; enantioselective reaction;
38 % ee	With Chr-OYE₁ (old yellow enzyme from chryseobacterium sp. CA₄₉); β-nicotinamide adenine dinucleotide reduced In aq. phosphate buffer at 30℃; for 0.0333333h; Enzymatic reaction; enantioselective reaction;	2.5 Bioreduction of activated alkenes and product analysis General procedure: The bioreduction of various substrates was performed in 1-ml reaction system containing 100mM potassium phosphate buffer (pH 7.0), 10mM NADH, 5mM substrate, and 50μg purified Chr-OYE1 or 500μg purified Chr-OYE2. After 2-min or 16-h incubation at 30°C for Chr-OYE1 and Chr-OYE2, respectively, the reactions were terminated by extraction with ethyl acetate. The organic phase was analyzed using GC or HPLC. (0013) Preparative-scale biotransformation was performed in 30-ml reaction system for substrates 4a, 6a, and 12a-17a catalyzed with Chr-OYE1. The incubation was continued for 12h. The extracted organic phase was combined and concentrated under reduced pressure. The final product was purified with column chromatography and subjected to GC or HPLC analysis, as well as NMR analysis to confirm the structure and purity.
1: 14 % ee 2: 40 % ee	With 5%-palladium/activated carbon; hydrogen; <i>L</i>-proline at 24.84℃; for 0.25h; enantioselective reaction;
37 % ee	With tetrabutylphosphonium (S)-(+)-prolinate; hydrogen; palladium dichloride In isopropyl alcohol at 20℃; for 18h; Schlenk technique; Inert atmosphere; Green chemistry; enantioselective reaction;
85 % ee	With (acetylacetonato)dicarbonylrhodium (l); C₄₁H₃₆O₃P₂ In toluene at 40℃; for 20h;
77.4 % ee	With (acetylacetonato)dicarbonylrhodium (l); (1S,1′S)-(+)-(2,7-di-tert-butyl-9,9-dimethyl-9H-xanthene-4,5-diyl)bis((2-methoxyphenyl)(phenyl)phosphine); hydrogen In toluene at 40℃; for 20h; Autoclave; enantioselective reaction;	4.2. General procedure for the asymmetric hydrogenation General procedure: All reactions were carried out using an automatic device[HPChemScan, Fa. HEL Ltd.] which allows the parallel hydrogenation in up to eight mini-autoclaves (16 mL). Every autoclave was equipped with a proper glass vial and loaded with 0.5 mmmol Rh precursor and 0.6 mmol of ligand 2 or 6. After assembling of autoclavesinto the device isophorone (1 mmol, 3 mL of a 0.333 M stocksolution) was added under argon atmosphere. The autoclaves were purged three times with argon (0.6 MPa) and then three times with hydrogen (1 MPa). The autoclaves were heated to 40 C under ambient pressure. Then hydrogen pressure was adjusted to 5 MPa.When the reaction was finished the system was cooled down and after release of pressure the autoclaves were purged again with argon (5 cycles). The conversion and parts of product and undesire dalcohol were estimated by NMR. The enantioselectivities were determined by gas chromatography.
50.1 % ee	With acetylacetonato(1,5-cyclooctadiene)rhodium(I); (1S,1′S)(+)(9,9-dimethyl-9H-xanthene-4,5-diyl)bis((2-methylphenyl)(phenyl)phosphine); hydrogen In toluene at 40℃; for 15h; Autoclave; enantioselective reaction;	4.2. General procedure for the asymmetric hydrogenation General procedure: All reactions were carried out using an automatic device[HPChemScan, Fa. HEL Ltd.] which allows the parallel hydrogenation in up to eight mini-autoclaves (16 mL). Every autoclave was equipped with a proper glass vial and loaded with 0.5 mmmol Rh precursor and 0.6 mmol of ligand 2 or 6. After assembling of autoclavesinto the device isophorone (1 mmol, 3 mL of a 0.333 M stocksolution) was added under argon atmosphere. The autoclaves were purged three times with argon (0.6 MPa) and then three times with hydrogen (1 MPa). The autoclaves were heated to 40 C under ambient pressure. Then hydrogen pressure was adjusted to 5 MPa.When the reaction was finished the system was cooled down and after release of pressure the autoclaves were purged again with argon (5 cycles). The conversion and parts of product and undesire dalcohol were estimated by NMR. The enantioselectivities were determined by gas chromatography.

Reference： [1]Current Patent Assignee: CHINA UNIVERSITY OF PETROLEUM (HUADONG) - CN106518637, 2017, A Location in patent: Paragraph 0022; 0047
[2]Massonneau, Viviane; le Maux, Paul; Simonneaux, Gerard [Tetrahedron Letters, 1986, vol. 27, # 45, p. 5497 - 5498]
[3]Lipshutz, Bruce H.; Papa, Patrick [Angewandte Chemie - International Edition, 2002, vol. 41, # 23, p. 4580 - 4582]
[4]Mhadgut, Shilpa C; Bucsi, Imre; Toeroek, Marianna; Toeroek, Bela [Chemical Communications, 2004, # 8, p. 984 - 985]
[5]Massonneau, Viviane; Maux, Paul Le; Simonneaux, Gerard [Journal of Organometallic Chemistry, 1987, vol. 327, p. 269 - 274]
[6]Massonneau, Viviane; Maux, Paul Le; Simonneaux, Gerard [Journal of Organometallic Chemistry, 1987, vol. 327, p. 269 - 274]
[7]Location in patent: experimental part Gyorffy, Nora; Tungler, Antal; Fodor, Matyas [Journal of Catalysis, 2010, vol. 270, # 1, p. 2 - 8]
[8]Peters, Christin; Koelzsch, Regina; Kadow, Maria; Skalden, Lilly; Rudroff, Florian; Mihovilovic, Marko D.; Bornscheuer, Uwe T. [ChemCatChem, 2014, vol. 6, # 4, p. 1021 - 1027]
[9]Ferlin, Nadege; Courty, Matthieu; Van Nhien, Albert Nguyen; Gatard, Sylvain; Pour, Milan; Quilty, Brid; Ghavre, Mukund; Haiss, Annette; Kuemmerer, Klaus; Gathergood, Nicholas; Bouquillon, Sandrine [RSC Advances, 2013, vol. 3, # 48, p. 26241 - 26251]
[10]Ferlin, Nadege; Courty, Matthieu; Van Nhien, Albert Nguyen; Gatard, Sylvain; Pour, Milan; Quilty, Brid; Ghavre, Mukund; Haiss, Annette; Kuemmerer, Klaus; Gathergood, Nicholas; Bouquillon, Sandrine [RSC Advances, 2013, vol. 3, # 48, p. 26241 - 26251]
[11]Pei, Xiao-Qiong; Xu, Meng-Yu; Wu, Zhong-Liu [Journal of Molecular Catalysis B: Enzymatic, 2016, vol. 123, p. 91 - 99]
[12]Rodríguez-García, Laura; Hungerbühler, Konrad; Baiker, Alfons; Meemken, Fabian [Journal of the American Chemical Society, 2015, vol. 137, # 37, p. 12121 - 12130]
[13]Hayouni, Safa; Robert, Anthony; Ferlin, Nadège; Amri, Hassen; Bouquillon, Sandrine [RSC Advances, 2016, vol. 6, # 114, p. 113583 - 113595]
[14]Holz, Jens; Rumpel, Katharina; Spannenberg, Anke; Paciello, Rocco; Jiao, Haijun; Börner, Armin [ACS Catalysis, 2017, vol. 7, # 9, p. 6162 - 6169]
[15]Börner, Armin; Gandelman, Mark; Holz, Jens; Spannenberg, Anke; Wenzel, Gudrun [Tetrahedron, 2020]
[16]Börner, Armin; Gandelman, Mark; Holz, Jens; Spannenberg, Anke; Wenzel, Gudrun [Tetrahedron, 2020]

2
[ 78-59-1 ]
[ 33496-82-1 ]

Yield	Reaction Conditions	Operation in experiment
99.8%	With dodecacarbonyltetrarhodium⁽⁰⁾; (S)-bis(4-(tert-butyl)phenyl)methyl-3-(1-acetyl-1H-indol-3-yl)-2-aminopropanoate; hydrogen; triphenylphosphine In toluene at 90℃; for 10h; Autoclave;	1 Example 1 Under an argon atmosphere, 52.7 mg(S) -bis (4- (tert-butyl) phenyl) methyl 3- (1-acetyl-1H-indol-3-yl) -2-aminopropanoate,18.7 mg Rh4 (CO) 12,26.2 mg of triphenylphosphine was dissolved in 40 mL of toluene,And transferred to a 100 mL autoclave,The molar ratio of 13.9 g of 3,5,5-trimethyl-2-cyclohexen-1-one, substrate / transition metal catalyst (same as the transition metal atom) = 1000 was injected into the autoclave, Hydrogen replacement tank gas three times Adjust the pressure to 80 bar. After stirring for 10 hours at 90 ° C,The conversion was 99.9% using gas chromatography as the productR-3,5,5-trimethylcyclohexanone, yield 99.8%Optical purity of 99ee%.
95%	Stage #1: 3,5,5-Trimethylcyclohex-2-en-1-one With polymethylhydrosiloxane; copper(l) chloride; sodium t-butanolate In tetrahydrofuran at -35℃; for 1h; Stage #2: In tetrahydrofuran Alkaline hydrolysis;
86%	With (R)-(-)-DTBM-SEGPHOS; sodium phenoxide; poly(methylhydrosiloxane) In toluene; <i>tert</i>-butyl alcohol at 20℃; for 3h; ultrasonication;

66%	With (2S,5S)-5-benzyl-3-methyl-2-(5-methyl-furan-2-yl)-imidazolidin-4-one; trichloroacetic acid In diethyl ether at 4℃; for 48h;
	With polymethylhydrosiloxane; copper diacetate; (R)-(-)-3,5-di-tert-butyl-4-methoxy-SEGPHOS In toluene at 20℃; for 1h;
	With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; polymethylhydrosiloxane; copper diacetate In toluene at 60℃; for 0.166667h; microwave irradiation;
	With RhH(CO)2[(R,R)-Chiraphos]; hydrogen In tetrahydrofuran at 60℃; for 72h; Inert atmosphere; optical yield given as %ee;
	With [(4S)-4-[5-bis(3,5-ditert-butyl-4-methoxy-phenyl)phosphanyl-1,3-benzodioxol-4-yl]-4,5,6,7-tetrahydro-1,3-benzodioxol-5-yl]-bis(3,5-ditert-butyl-4-methoxy-phenyl)phosphane; copper diacetate In toluene at 20℃; for 1.5h;	100.1 Step 1: (5R)-3,3,5-Trimethylcyclohexanone To a round bottom flask purged with nitrogen was added copper (II) acetate (14.53 mg, 0.08000 mmol), [(4S)-4-[5-bis(3,5-ditert-butyl-4-methoxy-phenyl)phosphanyl-1,3-benzodioxol-4-yl]-4,5,6,7-tetrahydro-1,3-benzodioxol-5-yl]-bis(3,5-ditert-butyl-4-methoxy-phenyl)phosphane (47.34 mg, 0.04000 mmol), and toluene (27.64 mL). The reaction was stirred at room temperature for 90 minutes. Polymethylhydrosiloxane (4.8 mL) was added and the reaction was allowed to stir at room temperature for 30 minutes. 3,5,5-Trimethylcyclohex-2-en-1-one (5.528 g, 6.009 mL, 40.00 mmol) was then added dropwise and the reaction was allowed to stir for 90 minutes at room temperature. The reaction was poured into a solution of 3M sodium hydroxide and allowed to stir vigorously for 2 hours. The crude reaction was extracted with ethyl acetate and dried over sodium sulfate. The solvent was removed and the crude product was taken onto the next step without further purification to give (5R)-3,3,5-trimethylcyclohexanone (5.1 g, 36 mmol, 91%) ESI-MS m/z calc. 140.12012. found 141.2 (M+1)+. Retention time: 1.44 minutes was a pale oil.
> 99 % ee	With glucose-6-phosphate In dimethyl sulfoxide at 24℃; for 3h; Sealed tube; Darkness; Enzymatic reaction;
	With copper diacetate; [(4S)-4-[5-bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphanyl-1,3-benzodioxol-4-yl]-4,5,6,7-tetrahydro-1,3-benzodioxol-5-yl]-bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphane In toluene at 20℃; for 1.5h;	100.1 Step 1: (5R )-3,3,5-trimethylcyclohexanone Add copper(II) acetate (14.53mg, 0.08000mmol) to a round bottom flask purged with nitrogen,[(4S )-4-[5-bis(3,5-di-tert-butyl-4-methoxy-phenyl)Phosphanyl-1,3-benzodioxol-4-yl]-4,5,6,7-tetrahydro-1,3-benzodioxol-5- Yl]-bis(3,5-di-tert-butyl-4-methoxy-phenyl)phosphane (47.34 mg, 0.04000 mmol) and toluene (27.64 mL).The reaction was stirred at room temperature for 90 minutes.Polymethylhydrosiloxane (4.8 mL) was added and the reaction was stirred at room temperature for 30 minutes.Then 3,5,5-trimethylcyclohex-2-en-1-one (5.528 g, 6.009 mL, 40.00 mmol) was added dropwise and the reaction was stirred at room temperature for 90 minutes.The reaction was poured into a3M sodium hydroxide solution and stirred vigorously for 2 hours.The crude reaction was extracted with ethyl acetate and dried over sodium sulfate. The solvent was removed and the crude product was used in the next step without further purification to obtain (5R )-3,3,5-trimethylcyclohexanone (5.1 g, 36 mmol, 91%) as a light oil.

Reference： [1]Current Patent Assignee: WANHUA CHEMICAL GROUP CO LTD - CN106905124, 2017, A Location in patent: Paragraph 0079; 0080
[2]Lipshutz, Bruce H.; Servesko, Jeff M.; Petersen, Tue B.; Papa, Patrick P.; Lover, Andrew A. [Organic Letters, 2004, vol. 6, # 8, p. 1273 - 1275]
[3]Lipshutz, Bruce H.; Frieman, Bryan A.; Tomaso Jr., Anthony E. [Angewandte Chemie - International Edition, 2006, vol. 45, # 8, p. 1259 - 1264]
[4]Tuttle, Jamison B.; Ouellet, Stephane G.; MacMillan, David W. C. [Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12662 - 12663]
[5]Lipshutz, Bruce H.; Frieman, Bryan A. [Angewandte Chemie - International Edition, 2005, vol. 44, # 39, p. 6345 - 6348]
[6]Lipshutz, Bruce H.; Frieman, Bryan A.; Unger, John B.; Nihan, Danielle M. [Canadian Journal of Chemistry, 2005, vol. 83, # 6-7, p. 606 - 614]
[7]Scheuermann Nee Taylor, Caroline J.; Jaekel, Christoph [Advanced Synthesis and Catalysis, 2008, vol. 350, # 17, p. 2708 - 2714]
[8]Current Patent Assignee: VERTEX PHARMACEUTICALS (OLD) - US2016/95858, 2016, A1 Location in patent: Paragraph 4785; 4786
[9]Mathew, Sam; Trajkovic, Milos; Kumar, Hemant; Nguyen, Quoc-Thai; Fraaije, Marco W. [Chemical Communications, 2018, vol. 54, # 79, p. 11208 - 11211]
[10]Current Patent Assignee: VERTEX PHARMACEUTICALS (OLD) - TW2017/13617, 2017, A Location in patent: Page/Page column 1042-1043

3
[ 78-59-1 ]
[ 470-99-5 ]
[ 116-02-9 ]
[ 33496-82-1 ]

Reference： [1]Synlett,2009,p. 3143 - 3146
[2]Synlett,2009,p. 3143 - 3146

4
[ 78-59-1 ]
[ 116-02-9 ]
[ 33496-82-1 ]

Reference： [1]Synlett,2009,p. 3143 - 3146

5
[ 78-59-1 ]
[ 33496-83-2 ]
[ 116-02-9 ]
[ 33496-82-1 ]

Yield	Reaction Conditions	Operation in experiment
	With (acetylacetonato)dicarbonylrhodium (l); (1S,1?S)-(+)-(9,9-dimethyl-9H-xanthene-4,5-diyl)bis((2-methoxyphenyl)(phenyl)phosphine); hydrogen; In toluene; at 40℃; under 37503.8 Torr; for 8h;Autoclave;	General procedure: All reactions were carried out using an automatic device[HPChemScan, Fa. HEL Ltd.] which allows the parallel hydrogenation in up to eight mini-autoclaves (16 mL). Every autoclave was equipped with a proper glass vial and loaded with 0.5 mmmol Rh precursor and 0.6 mmol of ligand 2 or 6. After assembling of autoclavesinto the device isophorone (1 mmol, 3 mL of a 0.333 M stocksolution) was added under argon atmosphere. The autoclaves were purged three times with argon (0.6 MPa) and then three times with hydrogen (1 MPa). The autoclaves were heated to 40 C under ambient pressure. Then hydrogen pressure was adjusted to 5 MPa.When the reaction was finished the system was cooled down and after release of pressure the autoclaves were purged again with argon (5 cycles). The conversion and parts of product and undesire dalcohol were estimated by NMR. The enantioselectivities were determined by gas chromatography.
	With acetylacetonato(1,5-cyclooctadiene)rhodium(I); (1S,1?S)-(+)-(9,9-dimethyl-9H-xanthene-4,5-diyl)bis((2-methoxyphenyl)(phenyl)phosphine); hydrogen; In toluene; at 40℃; under 37503.8 Torr; for 8h;Autoclave;	General procedure: All reactions were carried out using an automatic device[HPChemScan, Fa. HEL Ltd.] which allows the parallel hydrogenation in up to eight mini-autoclaves (16 mL). Every autoclave was equipped with a proper glass vial and loaded with 0.5 mmmol Rh precursor and 0.6 mmol of ligand 2 or 6. After assembling of autoclavesinto the device isophorone (1 mmol, 3 mL of a 0.333 M stocksolution) was added under argon atmosphere. The autoclaves were purged three times with argon (0.6 MPa) and then three times with hydrogen (1 MPa). The autoclaves were heated to 40 C under ambient pressure. Then hydrogen pressure was adjusted to 5 MPa.When the reaction was finished the system was cooled down and after release of pressure the autoclaves were purged again with argon (5 cycles). The conversion and parts of product and undesire dalcohol were estimated by NMR. The enantioselectivities were determined by gas chromatography.

Reference： [1]Tetrahedron,2020
[2]Tetrahedron,2020

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P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 33496-82-1 ] {[proInfo.proName]}

Quality Control of [ 33496-82-1 ]

Related Doc. of [ 33496-82-1 ]

Product Details of [ 33496-82-1 ]

Safety of [ 33496-82-1 ]

Application In Synthesis of [ 33496-82-1 ]

[ 33496-82-1 ] Synthesis Path-Upstream 1~2

[ 33496-82-1 ] Synthesis Path-Downstream 1~5

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry