Alternatived Products of [ 3352-05-4 ]
Product Details of [ 3352-05-4 ]
CAS No. : | 3352-05-4 |
MDL No. : | MFCD01651827 |
Formula : |
C9H6N2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
142.16
|
Pubchem ID : | - |
Synonyms : |
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Safety of [ 3352-05-4 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 3352-05-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 3352-05-4 ]
- 1
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[ 13026-12-5 ]
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[ 3352-05-4 ]
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[ 1268494-58-1 ]
- 2
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[ 2909-79-7 ]
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[ 3352-05-4 ]
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[ 1268830-98-3 ]
- 3
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[ 1394827-04-3 ]
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[ 3352-05-4 ]
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[ 1394827-27-0 ]
Yield | Reaction Conditions | Operation in experiment |
66% |
With potassium acetate; silver(I) acetate; palladium diacetate In N,N-dimethyl-formamide at 90℃; for 12h; Inert atmosphere; regioselective reaction; |
|
- 4
-
[ 3240-10-6 ]
-
[ 3352-05-4 ]
-
[ 1394827-72-5 ]
Yield | Reaction Conditions | Operation in experiment |
77% |
With palladium diacetate; silver carbonate In 1,4-dioxane; dimethyl sulfoxide at 80℃; for 12h; Inert atmosphere; |
|
- 5
-
[ 3352-05-4 ]
-
[ 166328-07-0 ]
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[ 1394827-47-4 ]
Yield | Reaction Conditions | Operation in experiment |
46% |
With potassium acetate; silver(I) acetate; palladium diacetate In N,N-dimethyl-formamide at 90℃; for 12h; Inert atmosphere; regioselective reaction; |
|
- 6
-
[ 3352-05-4 ]
-
[ 166328-08-1 ]
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[ 1394827-29-2 ]
Yield | Reaction Conditions | Operation in experiment |
91% |
With potassium acetate; silver(I) acetate; palladium diacetate In N,N-dimethyl-formamide at 90℃; for 12h; Inert atmosphere; regioselective reaction; |
|
- 7
-
[ 7436-90-0 ]
-
[ 3352-05-4 ]
-
[ 1394827-58-7 ]
Yield | Reaction Conditions | Operation in experiment |
84% |
With silver(I) acetate; cesium acetate; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether In N,N-dimethyl-formamide at 100℃; for 24h; Inert atmosphere; |
Preparation of C-3 Alkynylation Indolizine
General procedure: A mixture of indolizines (0.3 mmol), vinyl dibromides (0.9 mmol), Pd(OAc)2(7 mg, 10 mol%), DPEPhos (30 mg, 20 mol%), AgOAc (100 mg, 0.6 mmol), and CsOAc (170 mg, 0.9 mmol) in DMF (2 mL) was stirred at 100 °C under N2 for 24 h. Afterward, the mixture was cooled to room temperature and filtered through a pad of celite. The crude product was dissolved in Et2O (20 mL), washed with water (220 mL) and brine (20 mL), then dried over Na2SO4. The solvent was evaporated under reduced pressure, and the residue was subjected to flash column chromatography to obtain the desired product. |
- 8
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[ 3352-05-4 ]
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[ 1864-94-4 ]
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phenyl 1-cyanoindolizine-3-carboxylate
[ No CAS ]
- 9
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[ 873-55-2 ]
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[ 3352-05-4 ]
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[ 127-63-9 ]
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[ 3352-06-5 ]
Yield | Reaction Conditions | Operation in experiment |
1: 71%
2: 14% |
With palladium diacetate; copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 100℃; for 6h; |
|
1: 33%
2: 27% |
With palladium diacetate; silver nitrate In acetonitrile at 100℃; for 6h; |
|
Reference:
[1]Wang, Chunjie; Jia, Huali; Li, Zhiwei; Zhang, Hui; Zhao, Baoli
[RSC Advances, 2016, vol. 6, # 26, p. 21814 - 21821]
[2]Wang, Chunjie; Jia, Huali; Li, Zhiwei; Zhang, Hui; Zhao, Baoli
[RSC Advances, 2016, vol. 6, # 26, p. 21814 - 21821]
- 10
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[ 1950-68-1 ]
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[ 3352-05-4 ]
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3-(4-methoxyphenyl)indolizine-1-carbonitrile
[ No CAS ]
- 11
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[ 15959-31-6 ]
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[ 3352-05-4 ]
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3-(4-Nitro-phenyl)-indolizine-1-carbonitrile
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
81% |
With [2,2]bipyridinyl; tert-butyl peroxyacetate; palladium diacetate In acetonitrile at 100℃; for 6h; |
|
- 12
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[ 89520-70-7 ]
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[ 3352-05-4 ]
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C15H9BrN2
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
85% |
With [2,2]bipyridinyl; tert-butyl peroxyacetate; palladium diacetate In acetonitrile at 100℃; for 6h; |
|
- 13
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[ 63735-42-2 ]
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[ 3352-05-4 ]
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[ 1394827-48-5 ]
- 14
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[ 3352-05-4 ]
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[ 64326-13-2 ]
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[ 1394827-47-4 ]
Yield | Reaction Conditions | Operation in experiment |
77% |
With [2,2]bipyridinyl; tert-butyl peroxyacetate; palladium diacetate In acetonitrile at 100℃; for 6h; |
|
- 15
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[ 1074-12-0 ]
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[ 3352-05-4 ]
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3-(2-oxo-2-phenylacetyl)indolizine-1-carbonitrile
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
89% |
With rose bengal In dimethyl sulfoxide at 20℃; for 12h; Irradiation; Sealed tube; regioselective reaction; |
|
89% |
With rose bengal In dimethyl sulfoxide at 20℃; for 12h; Irradiation; |
2 Sample preparation and testing:
Put 14.2mg (0.1mmol) of 1-cyanoindoleazine and 1.1mg (0.001mmol) of Rose Bengal in a 25ml test tube with a stir bar,After adding 1 mL of dimethyl sulfoxide at room temperature, add 20.1 mg (0.15 mmol) of 2-oxo-2-phenylacetaldehyde,Stir under blue light irradiation for 12 hours, spin-dry and flash column chromatography to obtain the target product. |
58% |
With iron(III) chloride In toluene at 80℃; for 6h; |
|
Reference:
[1]Teng, Lili; Liu, Xiang; Guo, Pengfeng; Yu, Yue; Cao, Hua
[Organic Letters, 2020, vol. 22, # 10, p. 3841 - 3845]
[2]Current Patent Assignee: GUANGDONG PHARMACEUTICAL UNIVERSITY - CN111269228, 2020, A
Location in patent: Paragraph 0050-0058
[3]Samanta, Sadhanendu; Mondal, Susmita; Santra, Sougata; Kibriya, Golam; Hajra, Alakananda
[Journal of Organic Chemistry, 2016, vol. 81, # 20, p. 10088 - 10093]