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[ CAS No. 342-52-9 ] {[proInfo.proName]}

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Chemical Structure| 342-52-9
Chemical Structure| 342-52-9
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CAS No. :342-52-9 MDL No. :MFCD09033754
Formula : C8H7FN2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 198.15 Pubchem ID :-
Synonyms :

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 342-52-9 ]
  • Downstream synthetic route of [ 342-52-9 ]

[ 342-52-9 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 342-52-9 ]
  • [ 21397-07-9 ]
Reference: [1] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1976, vol. 30, p. 141 - 149
  • 2
  • [ 342-52-9 ]
  • [ 59255-94-6 ]
Reference: [1] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1976, vol. 30, p. 141 - 149
  • 3
  • [ 342-52-9 ]
  • [ 17809-36-8 ]
YieldReaction ConditionsOperation in experiment
74% at 50℃; for 2 h; 3g (0.0151mol) of 52 N-(2-fluoro-6-nitrophenyl)acetamide (3a) are dissolved in 30ml of 53 concentrated H2SO4 and brought to 50°C for 2h. After cooling, the solution is poured into an ice bath and an abundant precipitate is observed. After filtration, the acidic aqueus solution is extracted with diethyl ether. The pure 9 compound is obtained through flash chromatography. Yield 74percent. M.P. 47–48°C. 1H NMR (DMSO‑d6): δ 7.82 (d, 1H, J=8.8MHz, H-5), 7.42 (m, 1H, H-3), 7.25 (s, 2H, NH2), 6.63 (m, 1H, H-4). GC/MS: 157 (M+H). Anal. Calcd for (C6H5FN2O2): C, 46.16; H, 3.23; F, 12.17; N, 17.94. Found: C, 46.18; H, 3.27; F, 12.15; N, 17.98.
Reference: [1] European Journal of Medicinal Chemistry, 2019, vol. 161, p. 399 - 415
[2] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1976, vol. 30, p. 141 - 149
  • 4
  • [ 342-52-9 ]
  • [ 124-41-4 ]
  • [ 17809-36-8 ]
Reference: [1] Recueil des Travaux Chimiques des Pays-Bas, 1949, vol. 68, p. 88,89
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