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CAS No. : | 359878-55-0 | MDL No. : | MFCD01653581 |
Formula : | C14H22N2O | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 234.34 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51% | With formic acid; palladium 10% on activated carbon In methanol for 24 h; Inert atmosphere; Reflux | Example 88 N-((3-hydroxy-4-methylphenyl)methyl)-N-(1-methylpiperidin-4-yl)-2-(4-methoxyphenyl)acetamide (57MBT54B) N-((4-methoxyphenyl)methyl)-4-amino-1-methylpiperidine (1 g, 4.27 mmol) was dissolved in 4percent formic acid in methanol (60 mL). 10percent Pd/C (1 g) was added under argon and the reaction mixture was heated to reflux for 24 h. The mixture was filtered through celite and the filtrate was acidified with conc. HCl to pH 1. Concentration yielded a yellow oil which was purified by flash chromatography (MeOH/CH2Cl2 3:7+3.5percent NH4OH) to give 249 mg (51percent) of 4-amino-1-methylpiperidine (57-MBT36B) as a white solid. Rf=0.13 (10percent MeOH in CH2Cl2+3.5percent NH4OH). HPLC-MS (method B) showed MH+=115. UV/MS (percent)=-/100. |