Alternatived Products of [ 364328-07-4 ]
Product Details of [ 364328-07-4 ]
CAS No. : | 364328-07-4 |
MDL No. : | |
Formula : |
C7H8FNO
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
141.14
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 364328-07-4 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 364328-07-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 364328-07-4 ]
- 1
-
[ 1227210-35-6 ]
-
[ 364328-07-4 ]
- 2
-
[ 3013-27-2 ]
-
[ 364328-07-4 ]
- 3
-
sodium perborate
[ No CAS ]
-
[ 1227210-37-8 ]
-
[ 7732-18-5 ]
-
[ 364328-07-4 ]
Yield | Reaction Conditions | Operation in experiment |
81% |
In tetrahydrofuran; at 20℃; |
[00228]6-Fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)aniline (211 mg,0.840 mmol) was completely dissolved in THF (4 mL). Water (2 mL) was added followed by sodium perborate (333 mg, 2.16 mmol). The mixture was stirred at ambient temperature overnight. Excess THF was removed under vacuo - some solid appeared. Saturated ammonium chloride was added - a precipitate formed. DCM was added and the mixture stirred vigourouslyfor 15 minutes before passing through a hydrophobic frit. Concentration of the DCM gave 3- amino-4-fluoro-2-methylphenol as a pale pink/brown solid 107mg, 81%.[00229] 1 H NMR (DMSO-d6): O 8.82 (5, 1 H), 6.61 (dd, J = 8.9 and 11 .4 Hz, 1 H), 6.0 (dd,J= 4.4 and 8.9 Hz, 1H), 4.67 (bs, 2H), 1.91 (5, 3H). |
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