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Chemical Structure| 39557-31-8 Chemical Structure| 39557-31-8

Structure of 39557-31-8

Chemical Structure| 39557-31-8

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Product Details of [ 39557-31-8 ]

CAS No. :39557-31-8
Formula : C3H4ClI
M.W : 202.42
SMILES Code : C=C(Cl)CI
MDL No. :MFCD20415082

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Application In Synthesis of [ 39557-31-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 39557-31-8 ]

[ 39557-31-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 39557-31-8 ]
  • [ 14062-29-4 ]
  • C13H14Cl2O2 [ No CAS ]
  • 2
  • [ 39557-31-8 ]
  • [ 181765-85-5 ]
  • methyl 4-chloro-2-(2-chloroallyl)benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: To a solution of the corresponding benzoate (1.0 equiv) in dry THF (2.0 mL per 1.0 mmol of benzoate) under N2 atm was cooled to -40 C. Then, i-PrMgCl (2.0 equiv, 2M in THF) was added dropwise and stirred for 0.5 h at the same temperature. Afterwards CuCN.2LiCl (0.1 equiv) was added and after 5 minutes 2-chloro-3-iodo-propene (2.0 equiv) were added slowly. Then, the reaction was allowed to warm up at room temperature for 1.5 h. The reaction was quenched with saturated aqueous NH4Cl and extracted with diethyl ether. The combined organic layer was washed with brine, dried over anhydrous Na2SO4, concentrated by rotary evaporation, and purified by column chromatography to give 22a and 22b.
 

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